A5027806287- Nutrition and Health in Aging
- Sleep and related disorders
- Body Composition Measurement Techniques
- Dementia and Cognitive Impairment Research
- Health disparities and outcomes
- Autophagy in Disease and Therapy
- Frailty in Older Adults
- Intergenerational Family Dynamics and Caregiving
- Intensive Care Unit Cognitive Disorders
- Plant Stress Responses and Tolerance
- Telomeres, Telomerase, and Senescence
- Obesity, Physical Activity, Diet
- Photosynthetic Processes and Mechanisms
- HIV-related health complications and treatments
- Gut microbiota and health
- Gastrointestinal motility and disorders
- Biochemical effects in animals
- Demographic Trends and Gender Preferences
- Diabetic Foot Ulcer Assessment and Management
- Neurogenetic and Muscular Disorders Research
- Sex and Gender in Healthcare
- NF-κB Signaling Pathways
- Barrier Structure and Function Studies
- Sleep and Work-Related Fatigue
- Liver physiology and pathology
West China Hospital of Sichuan University
2021-2024
Sichuan University
2020-2024
Nanchang University
2023
Second Affiliated Hospital of Nanchang University
2023
State Key Laboratory of Biotherapy
2020-2022
National Clinical Research
2021
Sichuan Agricultural University
2015-2018
Beijing Microelectronics Technology Institute
2014
Abstract Nicotinamide adenine dinucleotide (NAD + ) is indispensable for the anti-aging activity of sirtuin (SIRT) family enzymes. AMP-activated protein kinase (AMPK) upregulates NAD synthesis and SIRT in a nicotinamide phosphoribosyltransferase (NAMPT)-dependent manner. However, molecular mechanisms that affect AMPK-driven NAMPT expression /SIRT activation remain unclear. In this study, we tried to identify senescence-associated microRNAs (miRNAs) negatively regulate cascade linking AMPK...
Oxidative stress-induced DNA damage, the senescence-associated secretory phenotype (SASP), and impaired autophagy all are general features of senescent cells. However, cross-talk among these events processes is not fully understood. Here, using NIH3T3 cells exposed to hydrogen peroxide stress, we show that damage provokes SASP largely via cytosolic chromatin fragment (CCF) formation, which activates a cascade comprising cGMP-AMP synthase (cGAS), stimulator interferon genes protein (STING),...
Abstract Objectives Associations between cognitive decline and depression have been inconclusive. We examined 1) whether sleep quality mediates these relationships 2) which factor of relationships. Methods This study utilized baseline data from the 2018 West China Health Aging Trend (WCHAT), a large cohort data-set that including participants aged over 50 years old. defined using 15-item Geriatric Depression Scale (GDS-15). Cognitive status was measured Short Portable Mental Status...
The gut microbiome and fecal metabolites have been found to influence sarcopenia, but whether there are potential bacteria that can alleviate sarcopenia has under-investigated, the molecular mechanism remains unclear.
Signal transducer and activator of transcription 3 (STAT3) is implicated in inflammation processing, but the mechanism its regulation mostly remains limited to Janus kinase (JAK)-mediated phosphorylation. Although AMP-activated protein (AMPK)-mediated STAT3 inactivation has got documented, molecular signalling cascade connecting anti-inflammatory role AMPK far from established. In present study, we addressed interplay between STAT3, revealed important function lipopolysaccharide-stressed...
Introduction: The aim of this study was to investigate the prevalence and associated factors sarcopenia defined by different criteria in community-dwelling adults west China using baseline data West-China Health Aging Trend (WCHAT) study. Methods: Adults aged 50 years or older communities Yunnan, Guizhou, Sichuan, Xinjiang provinces were enrolled We applied 6 diagnostic (AWGS 2019, AWGS 2014, EWGSOP1, EWGSOP2, IWGS, FNIH) define sarcopenia. Muscle mass measured based on bioimpedance...
Abstract Background Sarcopenia is the decline in muscle strength and mass attributed to aging. The pathogenesis of sarcopenia may be triggered by oxidative stress uric acid (UA) has strong antioxidant properties. aim this study was investigate relationship between UA community-dwelling adults West China using baseline data Health Aging Trend (WCHAT) study. Design A cross-sectional Methods 4236 aged 50 years or older communities west were enrolled We applied Asian Working Group for (AWGS)...
Abstract Background and purpose Motoric cognitive risk (MCR) syndrome characterized by subjective complaints slow gait has been proposed validated as a pre‐dementia syndrome. The overall specific ethnic prevalence of MCR the associated factors are poorly understood in middle‐aged to older community‐dwelling residents west China. Methods present study included 6091 samples from prospective cohort study, West China Health Aging Trend (WCHAT). Multidimensional demography, lifestyle, social...
Nitric oxide (NO) is extensively involved in various growth processes and stress responses plants; however, the regulatory mechanism of NO-modulated cellular sugar metabolism still largely unknown. Here, we report that NO significantly inhibited monosaccharide catabolism by modulating metabolic enzymes through S-nitrosylation (mainly oxidizing dihydrolipoamide, a cofactor pyruvate dehydrogenase). These modifications led to decrease glycolysis ATP synthase activities as well declines content...
Background In 2022, the European Society for Clinical Nutrition and Metabolism (ESPEN) Association Study of Obesity (EASO) launched a consensus on diagnostic methods sarcopenic obesity (SO). The study aimed to identify prevalence agreement SO using different in cohort subjects from West China aged at least 50 years old. Methods A large multi-ethnic sample 4,155 participants Health Aging Trend (WCHAT) was analyzed. defined according newly published ESPEN/EASO. Furthermore, diagnosed as...
CO2 and other chemicals affect mosquito blood meal seeking behavior. Heat, humidity black color can also serve as orientation cues. However attraction does not necessarily mean that it will land. The sequence of the cues used for landing is unclear. We performed a field study with wild mosquitoes in an open space found no (except pyrethrins) could completely prevent from landing. mimics cyclopentanone pyridine attracted but did lead to No was caught absence heat, although presence CO2....
Abstract Objectives The relationship between the number of teeth and sarcopenia remains poorly investigated. Although nutrition plays an important role in maintaining bone muscle health, complex pathogenesis to be elucidated. Methods A large multi-ethnic sample 4149 participants aged over 50 years old from West China Health Aging Trend (WCHAT) study was analyzed. We examined associations with nutritional status sarcopenia, mediating association sarcopenia. Sarcopenia defined according Asian...
Motoric cognitive risk syndrome (MCR), characterized by subjective complaints and slow gait in older populations, is associated with sleep duration. However, the association between MCR daytime nap duration has not been thoroughly explored. Baseline data from China Health Retirement Longitudinal Study (CHARLS) were used this study. was defined as coexistence of objective speed without a history dementia or mobility disability. Daytime categorized into four groups: no napping, short napping...
In this study, we investigated whether nutrition status mediates the relationship between cognitive decline and sarcopenia. Sarcopenia was assessed in 4023 community-dwelling older adults from West China using AWGS 2014 diagnostic criteria. Cognitive function were 10-item Short Portable Mental Status Questionnaire (SPMSQ) Mini Nutrition Assessment-Short Form (MNA-SF) scale, respectively. Mediation model regression analysis demonstrated that negatively associated with sarcopenia (β = -0.521;...
Aspirin decreases liver fibrosis index and inflammation levels. However, the exact mechanism underlying effects of aspirin are yet to be elucidated. The aim study was investigate potential protective on carbon tetrachloride (CCl4)-induced hepatic in Sprague-Dawley rats. Rats were divided into four groups, including healthy CCl4 control low-(aspirin 10 mg/kg + CCl4) high-dose group (aspirin 300 CCl4). After 8 weeks treatment, histopathological examinations hepatocyte serum levels alanine...
Thermomechanical cycle failure was analyzed in 808-nm high-power AlGaAs/GaAs laser diode bars (LDBs) detail. Two thermal stress experiments were carried out these devices with peak stresses of 19.4 and 33 MPa. The threshold current increase demonstrated a square-root dependence on the number, tail split lasing spectrum observed. This result attributed to nonradiative recombination increasing number due diffusion defects that accompanies band-structure renormalization. Furthermore, from X-ray...
Objectives Body mass index (BMI) and waist circumference (WC) are closely associated with metabolic syndrome its components. Hence, a combination of these two obesity markers may be more predictive. In this study, we aimed to investigate the individual combined associations BMI WC selected components explored whether age, sex ethnicity affected aforementioned associations. Methods A total 6,298 middle-aged older adults were included. Based on WC, participants divided into 4 groups: comorbid...
<title>Abstract</title> Background Sarcopenia not only leads to impaired physical function but may also be associated with changes in sleep and mental health as individuals age. Research on the relationship between sleep, anxiety, depression adultonset sarcopenia is limited; however, there are no reports indicating them different groups of sarcopenia. The aim this study explore correlation (diagnosed sarcopenia, severe sarcopenia) multiethnic region western China based 2019 Asian diagnostic...
Abstract Muscle atrophy, characterized by the loss of muscle mass and function, is a hallmark sarcopenia cachexia, frequently associated with aging, malignant tumors, chronic heart failure, malnutrition. Moreover, it poses significant challenges to human health, leading increased frailty, reduced quality life, heightened mortality risks. Despite extensive research on consensus in their assessment remains elusive, inconsistent conclusions regarding molecular mechanisms. atrophy models are...