A5000396744- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Nerve injury and regeneration
- Inflammasome and immune disorders
- Neurogenesis and neuroplasticity mechanisms
- Graphene and Nanomaterials Applications
- Flavonoids in Medical Research
- Stroke Rehabilitation and Recovery
- Curcumin's Biomedical Applications
- Pain Mechanisms and Treatments
- Hydrogels: synthesis, properties, applications
- Genomics, phytochemicals, and oxidative stress
- Circadian rhythm and melatonin
Capital Medical University
2019-2023
China Rehabilitation Research Center
2019-2023
Beijing Institute of Technology
2023
Qilu Hospital of Shandong University
2023
Beijing Tsinghua Chang Gung Hospital
2023
Microglia and infiltrated macrophages play important roles in inflammatory processes after ischemic stroke. Modulating microglia/macrophage polarization from pro-inflammatory phenotype to anti-inflammatory state has been suggested as a potential therapeutic approach the treatment of Melatonin shown be neuroprotective experimental stroke models. However, effect melatonin on microglia underlying mechanisms remain unknown.In vivo, cerebral ischemia was induced by distal middle artery occlusion...
NLRP3 inflammasome-mediated pyroptosis is a proinflammatory programmed cell death pathway, which plays vital role in functional outcomes after stroke. We previously described the beneficial effects of curcumin against stroke-induced neuronal damage through modulating microglial polarization. However, impact on remains unknown. Here, stroke was modeled mice by middle cerebral artery occlusion (MCAO) for 60 minutes and treated with (150 mg/kg) intraperitoneally immediately reperfusion,...
Stroke is the second leading cause of mortality and disability worldwide. Poststroke rehabilitation still unsatisfactory in clinics, which brings great pain economic burdens to stroke patients. In this study, an injectable hydrogel tannic acid (TA) acts as not only a building block but also therapeutic drug, was developed for poststroke rehabilitation.TA used form (TA gel) with carboxymethyl chitosan (CMCS) by multivalent hydrogen bonds. The morphology, rheological properties, TA release...
Stroke is one of the leading causes death and disability worldwide with limited therapeutic options. Melatonin can attenuate ischemic brain damage improved functional outcomes. However, cellular mechanisms melatonin-driven neuroprotection against post-stroke neuronal remain unknown. Here, distal middle cerebral artery occlusion (dMCAO) was performed in C57BL/6j mice to develop an stroke vivo model. injected intraperitoneally immediately after ischemia, 24 48 hours later. treatment, 5 20...
<title>Abstract</title> Background Stroke is the second leading cause of mortality and disability in world. Post-stroke rehabilitation still unsatisfactory clinics, which brings giant pains economic burdens to stroke patients. In this study, an injectable hydrogel where tannic acid (TA) acts as not only a building block but therapeutic drug was developed for post-stroke rehabilitation. Methods TA used form (TA-gel) with carboxymethyl chitosan (CMCS) by multivalent hydrogen bonds. The...