A5074260087- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Flavonoids in Medical Research
- Circadian rhythm and melatonin
- Inflammasome and immune disorders
- Curcumin's Biomedical Applications
- Genomics, phytochemicals, and oxidative stress
China Rehabilitation Research Center
2019-2021
Capital Medical University
2019-2021
Microglia and infiltrated macrophages play important roles in inflammatory processes after ischemic stroke. Modulating microglia/macrophage polarization from pro-inflammatory phenotype to anti-inflammatory state has been suggested as a potential therapeutic approach the treatment of Melatonin shown be neuroprotective experimental stroke models. However, effect melatonin on microglia underlying mechanisms remain unknown.In vivo, cerebral ischemia was induced by distal middle artery occlusion...
NLRP3 inflammasome-mediated pyroptosis is a proinflammatory programmed cell death pathway, which plays vital role in functional outcomes after stroke. We previously described the beneficial effects of curcumin against stroke-induced neuronal damage through modulating microglial polarization. However, impact on remains unknown. Here, stroke was modeled mice by middle cerebral artery occlusion (MCAO) for 60 minutes and treated with (150 mg/kg) intraperitoneally immediately reperfusion,...
Stroke is one of the leading causes death and disability worldwide with limited therapeutic options. Melatonin can attenuate ischemic brain damage improved functional outcomes. However, cellular mechanisms melatonin-driven neuroprotection against post-stroke neuronal remain unknown. Here, distal middle cerebral artery occlusion (dMCAO) was performed in C57BL/6j mice to develop an stroke vivo model. injected intraperitoneally immediately after ischemia, 24 48 hours later. treatment, 5 20...