A5040335267- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- biodegradable polymer synthesis and properties
- Tissue Engineering and Regenerative Medicine
- Cardiac Valve Diseases and Treatments
- Advanced Polymer Synthesis and Characterization
- Dendrimers and Hyperbranched Polymers
- Crystallography and molecular interactions
- Aortic Disease and Treatment Approaches
- Chemical Synthesis and Analysis
- Synthesis and properties of polymers
- Orthopaedic implants and arthroplasty
- 3D Printing in Biomedical Research
- Supramolecular Self-Assembly in Materials
- Liquid Crystal Research Advancements
- Solid-state spectroscopy and crystallography
- Crystallization and Solubility Studies
- Analytical Chemistry and Chromatography
- Molecular spectroscopy and chirality
- Photonic and Optical Devices
- Collagen: Extraction and Characterization
- Molecular Sensors and Ion Detection
- Connective tissue disorders research
- Advanced NMR Techniques and Applications
- Polymer composites and self-healing
SyMO-Chem (Netherlands)
2014-2025
Eindhoven University of Technology
1998-2021
Dutch Polymer Institute
2000-2012
Boston University
2005-2008
SupraPolix (Netherlands)
2008
Beth Israel Deaconess Medical Center
2008
Duke University
2005
Duke University Hospital
2005
Duke Medical Center
2005
Institute of Macromolecular Chemistry
2002
2-Ureido-4[1H]-pyrimidinones are known to dimerize via a strong quadruple hydrogen bond array. A detailed study of the dimerization constant and lifetime dimer is presented here. Excimer fluorescence pyrene-labeled 2-ureido-4[1H]-pyrimidinone 1b was used determine Kdim 6 × 107 M-1 in CHCl3, 1 chloroform saturated with water, 108 toluene (all at 298 K). Under these conditions, preexchange similar dimers both 1d 1e 170 ms CDCl3, 80 wet 1.7 s toluene-d8, as determined by dynamic NMR...
The creation of a living heart valve is much-wanted alternative for current prostheses that suffer from limited durability and thromboembolic complications. Current strategies to create such valves, however, require the use cells in vitro culture, or decellularized human- animal-derived donor tissue situ engineering. Here, we propose demonstrate proof-of-concept engineering using synthetic approach, which cell-free, slow degrading elastomeric valvular implant populated by endogenous form new...
Photo-crosslinkable dendritic macromolecules are attractive materials for the preparation of cartilage tissue engineering scaffolds that may be optimized in situ formation hydrated, mechanically stable, and well-integrated hydrogel supporting chondrocytes chondrogenesis. We designed synthesized a novel scaffold repair, based on multivalent water-soluble tri-block copolymer consisting poly(ethylene glycol) core methacrylated poly(glycerol succinic acid) dendrimer terminal blocks. The...
Abstract Sophisticated polymeric materials with “responsive” properties, such as self‐healing, are beginning to reach the market. Supramolecular polymers, i.e., polymers that owe their mechanical properties primarily reversible, non‐covalent interactions, hydrogen bonding between macromolecules, have frequently been employed self‐healing materials. The quadruple ureidopyrimidinone (UPy) unit is a particularly effective and versatile design motif, since it forms very strong but reversible...
A family of smectic liquid-crystalline dendrimers has been synthesized by connecting rodlike cyanobiphenyl mesogens, with various spacer lengths, at the periphery poly(propylene imine) dendrimers. combination differential scanning calorimetry, optical microscopy, and X-ray diffraction suggests that, under influence mesogenic endgroups, dendrimer to adopt a highly distorted conformation.
In order to investigate the effects of strong and well-defined hydrogen bonding on properties thermoplastic elastomers (TPEs), we have applied two distinct strongly dimerizing 2-ureido-4-[1H]-pyrimidinone (UPy) quadruple hydrogen-bonding units as physical cross-linker. While UPy groups consequently serve "hard phase" or block" in these TPEs, an amorphous polyester has been used "soft block". The unit flanked with either a sterically demanding isophorone spacer linear hexamethylene, where...
Engineering of anisotropic tissues demands extracellular matrix (ECM) mimicking scaffolds with an asymmetric distribution functionalities. We here describe a convenient, modular approach based on supramolecular building blocks to form electrospun bilayered tailorable properties. Polymers and peptides functionalized hydrogen-bonding ureido-pyrimidinone (UPy) moieties can easily be mixed-and-matched explore new material combinations optimal These combinatorial biomaterials, processed by...
ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication the EditorNEXTSelective Formation of Cyclic Dimers in Solutions Reversible Supramolecular PolymersSerge H. M. Söntjens, Rint P. Sijbesma, Marcel van Genderen, and E. W. MeijerView Author Information Laboratory Macromolecular Organic Chemistry, Eindhoven University Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands Cite this: Macromolecules 2001, 34, 12, 3815–3818Publication Date (Web):May 11, 2001Publication...
First generation, photocrosslinkable dendrimers consisting of natural metabolites (i.e., succinic acid, glycerol, and β-alanine) nonimmunogenic poly(ethylene glycol) (PEG) were synthesized divergently in high yields using ester carbamate forming reactions. Aqueous solutions these photocrosslinked with an eosin-based photoinitiator to afford hydrogels. The hydrogels displayed a range mechanical properties based on their structure, generation size, concentration solution. All the showed...
This study showed that bone marrow mononuclear cell pre-seeding had detrimental effects on functionality and in situ remodeling of bioresorbable bisurea-modified polycarbonate (PC-BU)-based tissue-engineered heart valves (TEHVs) used as transcatheter pulmonary valve replacement sheep. We also heterogeneous leaflet remodeling, which affects PC-BU TEHV safety, challenging their potential for clinical translation. suggest should not be combination with TEHVs. A better understanding...
Infections, cancer, and trauma can cause life-threatening hyperinflammation. In the present study, using single-cell RNA sequencing of circulating immune cells, we found that mammalian target rapamycin (mTOR) pathway plays a critical role in myeloid cell regulation COVID-19 patients. Previously, developed an mTOR-inhibiting nanobiologic (mTORi-nanobiologic) efficiently targets cells their progenitors bone marrow. vitro, demonstrated mTORi-nanobiologics potently inhibit infection-associated...
The biochemical complexity of a material determines the biological response cells triggered by cell-material interaction.
Adamantyl urea and adamantyl thiourea modified poly(propylene imine) dendrimers act as hosts for N-terminal tert-butoxycarbonyl (Boc)-protected peptides form chloroform-soluble complexes. Investigations with NMR spectroscopy show that the peptide is bound to dendrimer by ionic interactions between outer shell tertiary amines C-terminal carboxylic acid of peptide, also through host-urea peptide-amide hydrogen bonding. The hydrogen-bonding nature peptide–dendrimer was further confirmed using...
The structure of the quadruple hydrogen bond formed by ureido-pyrimidinone moieties is investigated in dimerised model compounds, as well a supramolecular polymer, solid-state 1H double-quantum (DQ) NMR spectroscopy under fast magic-angle spinning (MAS). This method combines sensitivity chemical shifts to strengths bonds with quantitative information about dipole–dipole couplings between pairs protons. Thus, two-dimensional DQ MAS spectra provide particularly detailed insight into...
With their excellent biocompatibility and relatively high mechanical strength, polylactides are attractive candidates for application in load-bearing, resorbable implants. Pre-clinical studies provided a proof of principle polylactide cages as temporary constructs to facilitate spinal fusion, several already made it the market. However, also failures have been reported: clinical reported considerable amounts subsidence with lumbar fusion cages, an vivo goat study, failed after only three...
Polylactides are commonly praised for their excellent mechanical properties (e.g. a high modulus and yield strength). In combination with bioresorbability biocompatibility, they considered prime candidates application in load-bearing biomedical implants. Unfortunately, however, long-term performance under static load is far from impressive. previous vivo study on degradable polylactide spinal cages goat model it was observed that, although short-term real-time degradation experiments...
Tissue engineering provides a promising tool for creating load-bearing cardiovascular tissues. Ideally, the neotissue produced by cells possesses native strength and anisotropy. By providing contact-guiding cues with microfibers, scaffold directionality can guide tissue organization. However, scaffolds transiently degrade, which may induce undesired remodeling in response to applied strain. We hypothesize that newly formed tissues, collagen matrix does not yet provide contact guidance cells,...
In situ vascular tissue engineering aims to regenerate vessels "at the target site" using synthetic scaffolds that are capable of inducing endogenous regeneration. Critical success this approach is a fine balance between functional neo-tissue formation and scaffold degradation. Circulating immune cells important regulators process as they drive host response play central role in resorption. Despite progress made with scaffolds, little known about development during after study, we designed...
An essential aspect of cardiovascular
The dispersion of dendrimers in a liquid crystal (LC) is reported as new approach to LC displays based on light scattering. It shown that the performance fifth-generation palmitoyl-functionalized poly(propylene imine) dendrimer—with 64 “legs”, Figure—as an electro-optical switch superior polymer-filled nematics and polymer-dispersed systems (see also cover).
Supramolecular polymers have shown to be powerful scaffolds for tissue engineering applications. biomaterials functionalized with ureidopyrimidinone (UPy) moieties, which dimerize via quadruple hydrogen-bond formation, are eminently suitable this purpose. The conjugation of the UPy moiety biologically active peptides ensures adequate integration into supramolecular polymer matrix. structural complexity UPy–peptide conjugates makes their synthesis challenging and until recently low yielding,...
The equilibrium between scaffold degradation and neotissue formation, is highly essential for in situ tissue engineering. Herein, biodegradable grafts function as temporal roadmap to guide regeneration. ability monitor understand the dynamics of deposition cardiovascular graft materials therefore great value accelerate implementation safe sustainable tissue-engineered vascular (TEVGs) a substitute conventional prosthetic grafts. In this study, we investigated potential Raman...