A5100394808- Bacteriophages and microbial interactions
- Microtubule and mitosis dynamics
- Genomics and Phylogenetic Studies
- Remote Sensing in Agriculture
- Gene Regulatory Network Analysis
- Genomics and Chromatin Dynamics
- Microbial Community Ecology and Physiology
- Cellular Mechanics and Interactions
- Bacterial Genetics and Biotechnology
- Evolution and Genetic Dynamics
- Protist diversity and phylogeny
- Antibiotic Resistance in Bacteria
- Microbial infections and disease research
- Lipid Membrane Structure and Behavior
- Bacterial biofilms and quorum sensing
- Photosynthetic Processes and Mechanisms
- Chromosomal and Genetic Variations
- DNA Repair Mechanisms
- Force Microscopy Techniques and Applications
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Remote Sensing and LiDAR Applications
- Calibration and Measurement Techniques
- Remote Sensing and Land Use
- Cancer Genomics and Diagnostics
Virginia Tech
2016-2025
Guangdong Academy of Medical Sciences
2024
Southern Medical University
2019-2024
Nanjing University
2016-2024
Guangdong Provincial People's Hospital
2024
Shihezi University
2022-2023
East China Normal University
2017-2023
East China University of Science and Technology
2006-2022
Zhengzhou University
2022
Xinjiang Production and Construction Corps
2022
Abstract Developing highly active nonprecious electrocatalysts with superior durability for both the hydrogen evolution reaction (HER) and oxygen (OER) is crucial to improve efficiency of overall water splitting but remains challenging. Here, a novel superhydrophilic Co 4 N‐CeO 2 hybrid nanosheet array synthesized on graphite plate (Co /GP) by an anion intercalation enhanced electrodeposition method, followed high‐temperature nitridation. Doping CeO into N can favor dissociation H O...
Myxococcus xanthus is a Gram-negative bacterium that glides over surfaces without the aid of flagella. Two motility systems are used for locomotion: social-motility, powered by retraction type IV pili, and adventurous (A)-motility, unknown mechanism(s). We have shown AgmU, an A-motility protein, part multiprotein complex spans inner membrane periplasm M. xanthus. In this paper, we present evidence periplasmic AgmU decorates looped continuous helix rotates clockwise as cells glide forward,...
Adjusting motility patterns according to environmental cues is important for bacterial survival.
Coronavirus nucleocapsid (N) protein envelops the genomic RNA to form long helical during virion assembly. Since N oligomerization is usually a crucial step in this process, characterization of such an will help understanding possible mechanisms for formation. The severe acute respiratory syndrome coronavirus (SARS-CoV) was recently discovered self-associate by its carboxyl terminus. In study, further address detailed association feature C-terminus, systematically investigated size exclusion...
Tetraploidy has long been of interest to both cell and cancer biologists, partly because its documented role in tumorigenesis. A common model proposes that the extra centrosomes are typically acquired during tetraploidization responsible for driving However, tetraploid cells evolved culture have shown lack centrosomes. This observation raises questions about how evolve more specifically mechanisms(s) underlying centrosome loss. Here, using a combination fixed analysis, live imaging,...
A novel virulent bacteriophage, φAbp2, infecting multidrug-resistant (MDR) Acinetobacter baumannii was isolated from the wastewater of a sewage management centre at Southwest Hospital, China. Transmission electron microscopy and phylogenetic analysis revealed that φAbp2 belongs to subfamily Peduovirinae. one-step growth curve demonstrated had latent period 15 min, lysis 35 burst size 222 particles per infected host cell. Moreover, showed relatively broad range in local A. baumannii, it also...
Why do some biological systems and communities persist while others fail? Robustness, a system's stability, resilience, the ability to return stable state, are key concepts that span multiple disciplines within outside sciences. Discovering applying common rules govern robustness resilience of is critical step toward creating solutions for species survival in face climate change, as well ever-increasing need food, health, energy human populations. We propose network theory provides framework...
Many bacteria move on solid surfaces using gliding motility, without involvement of flagella or pili. Gliding Myxococcus xanthus is powered by a proton channel homologous to the stators in bacterial flagellar motor. Instead being fixed place and driving rotation circular protein track like basal body, machinery M. travels length cell along helical trajectories, while mechanically engaging with substrate. Such movement entails different molecular mechanism generate propulsion cell. In this...
Perfluorooctane sulfonate (PFOS), an endocrine-disrupting chemical pollutant, affects embryonic heart development; however, the mechanisms underlying its toxicity have not been fully elucidated. Here, Single-cell RNA sequencing (scRNA-seq) was used to investigate overall effects of PFOS on myocardial differentiation from human stem cells (hESCs). Additionally, apoptosis, mitochondrial membrane potential, and ATP assays were performed. Downregulated cardiogenesis-related genes inhibited...
Coexistence of bacteriophages, or phages, and their host bacteria plays an important role in maintaining the microbial communities. In natural environments with limited nutrients, motile can actively migrate towards locations richer resources. Although phages are not themselves, they infect bacterial hosts spread space via hosts. Therefore, a migrating community coexistence implies co-propagation space. Here, we combine experimental approach mathematical modeling to explore how coexist...
Advancements in studies on the evolutionary mechanisms underlying bacterial antibiotic resistance are unclear. This study aimed to investigate mechanism using isobaric tags for relative and absolute quantitation-based quantitative proteomics along with functional validation. Quantitative analysis revealed 101, 325, 428 differentially expressed proteins (DEPs) at three drug levels (low-R, 0.2 μg/mL; medium-R, 5 high-R, 15 μg/mL). Continuous adjustment of metabolic patterns enhance nucleotide...
Antimicrobial resistance (AMR) is one of the most significant threats to global public health. As antibiotic failure increasing, phages are gradually becoming important agents in post-antibiotic era. In this study, therapeutic effects and safety kpssk3, a previously isolated phage infecting carbapenem-resistant hypermucoviscous Klebsiella pneumoniae (CR-HMKP), were evaluated mouse model systemic CR-HMKP infection. The efficacy experiment showed that intraperitoneal injection with single dose...
Circadian rhythms in a wide range of organisms are mediated by molecular mechanisms based on transcription-translation feedback. In this paper, we use bifurcation theory to explore mathematical models genetic oscillators, Kim & Forger’s interpretation the circadian clock mammals. At core their is negative feedback loop whereby PER proteins (PER1 and PER2) bind inhibit transcriptional activator, BMAL1. For oscillations occur, dissociation constant PER:BMAL1 complex, <mml:math...
Salmonella enterica serovar Pullorum affecting poultry causes pullorum disease and results in severe economic loss the industry. Currently, it remains a major threat countries with poor surveillance no efficient control measures. As S. could induce strong humoral immune responses, we applied an immunoscreening technique, vivo-induced antigen technology (IVIAT), to identify immunogenic bacterial proteins expressed or upregulated during infection. Convalescent-phase sera from chickens infected...
Background Unprecedented progresses in high-throughput DNA sequencing and de novo gene synthesis technologies have allowed us to create living organisms the absence of natural template. Methodology/Principal Findings The sequence wild-type S13 phage genome was downloaded from GenBank. Two synonymous mutations were introduced into wt-S13 generate m1-S13 genome. Another mutant, m2-S13 genome, obtained by engineering two nonsynonymous capsid protein coding region A chimeric designed replacing F...
Abstract The mitotic checkpoint (also called spindle assembly checkpoint, SAC) is a signaling pathway that safeguards proper chromosome segregation. Correct functioning of the SAC depends on adequate protein concentrations and appropriate stoichiometries between proteins. Yet very little known about regulation gene expression. Here, we show in fission yeast Schizosaccharomyces pombe combination short mRNA half‐lives long supports stable levels. For genes mad2 + mad3 , their are caused, part,...
In their classical work (Proc. Natl. Acad. Sci. USA, 1981, 78:6840–6844), Goldbeter and Koshland mathematically analyzed a reversible covalent modification system which is highly sensitive to the concentration of effectors. Its signal-response curve appears sigmoidal, constituting biochemical switch. However, switch behavior only emerges in ‘zero-order region’, i.e. when signal molecule much lower than that substrate it modifies. this we showed switching can also occur under comparable...