A5100714502- Plant Gene Expression Analysis
- Plant tissue culture and regeneration
- Aquaculture Nutrition and Growth
- Medical Imaging Techniques and Applications
- Neurobiology and Insect Physiology Research
- Algal biology and biofuel production
- Pharmacological Effects of Natural Compounds
- Healthcare and Venom Research
- Natural product bioactivities and synthesis
- Radiopharmaceutical Chemistry and Applications
- Plant biochemistry and biosynthesis
- Genomics and Phylogenetic Studies
- Biological and pharmacological studies of plants
- Traditional Chinese Medicine Analysis
- Plant-based Medicinal Research
- Advancements in Transdermal Drug Delivery
- Ginseng Biological Effects and Applications
- Plant and animal studies
- Berberine and alkaloids research
- Analytical Chemistry and Chromatography
- Nanoparticle-Based Drug Delivery
- Acute Myeloid Leukemia Research
- Bioactive Compounds and Antitumor Agents
- Radiomics and Machine Learning in Medical Imaging
- Spectroscopy and Chemometric Analyses
Soochow University
2019-2025
First Affiliated Hospital of Soochow University
2025
Guizhou University
2010-2025
University of Gothenburg
2024
Guiyang College of Traditional Chinese Medicine
2008-2022
Wuhan University
2019-2022
Shanxi Medical University
2022
First Hospital of Shanxi Medical University
2022
Aerospace Center Hospital
2019-2021
King's College London
2021
Bonded mono-, di- and oligosaccharides were developed as novel separation materials for HILIC via click chemistry proven to have excellent chromatographic properties of polar compounds.
B-cell acute lymphoblastic leukemia is the most common type of pediatric leukemia. Despite improved remission rates, current treatment regimens for are often associated with adverse effects and central nervous system relapse, necessitating more effective safer agents. Bafilomycin A1 an inhibitor vacuolar H+-ATPase that frequently used at high concentration to block late-phase autophagy. Here, we show bafilomycin a low (1 nM) effectively specifically inhibited killed cells. It targeted both...
Hua-Feng-Dan is a traditional Chinese medicine used to treat ischemic stroke, but little known about its therapeutic mechanism. This study explored whether and how the mechanism involves readjustment of gut microbiota. Rats were subjected middle cerebral artery occlusion as model stroke or sham surgery, then treated not with Hua-Feng-Dan. The different groups animals compared in terms neurological score, infarct volume, brain edema, histopathology assess severity. They also indices...
The crosstalk between megakaryocytic lineage cells and the skeletal system has just begun to be explored but remains largely elusive. Using conditional gene knockout mouse models, we demonstrated that loss of Beclin 1 (Becn1), a major regulator mammalian autophagy, exclusively in disrupted autophagy platelets did not compromise megakaryopoiesis or formation function platelets. Unexpectedly, Becn1 deletion male mice led remarkable increase bone mass with improved quality, association decrease...
The 16S rRNA gene sequences of reference strains Streptococcus suis serotypes 1–34 and 1/2 were determined. A comparative sequence analysis showed that the degree similarity between S. ranged from 93·94 to 100%. dendrogram was constructed matrix. Thirty-two representing 32 fell into a major group divided three clusters. other strains, 32, 33 34, more distant. Biochemical characterization six distant including 20, 22, 26, revealed profile similar serotypes. Comprison with members genus...
Bletilla striata (Thunb.) Rchb.f. is a perennial herb belonging to the Orchidaceae family. Its tubers are used in traditional Chinese medicine treat gastric ulcers, inflammation, silicosis tuberculosis, and pneumogastric hemorrhage. It has been reported that different soil types can affect growth of B. accumulation secondary metabolites its tubers, but biological mechanisms underlying these effects remain unclear. In this study, we compared agronomic traits (extractum, polysaccharide, total...
Fermentation is a traditional processing method that can impact the abundance of relevant components in Chinese herbal medicines. Huafeng Dan Yaomu was processed by fermentation. In this study, we investigated changes toxic alkaloids using high-performance liquid chromatography and analysed microbial communities during fermentation Illumina MiSeq platform. The results indicated highly alkaloid compounds including aconitine, mesaconitine hypaconitine were decreased, whereas benzoylmesaconine...
Corydalis yanhusuo W.T. Wang alkaloids are mainly divided into three categories: protoberberine, prototropine and aporphine alkaloids. Therefore, we have taken account these alkaloid contents when extracting purifying crude drugs, which is essential for the quality control of C. its derivative products. Herein, investigated feasibility Q-marker uniform design method in optimization extraction purification yanhusuo. In this study, Q-marker-based comprehensive scoring (CS) methods were used to...
Pancreatic cancer is a concealed and highly malignant tumor, its early diagnosis plays an increasingly weighty role during the course of treatment. In this study, we developed polymeric magnetic resonance imaging (MRI) nanoplatform for MRI contrast agents. To improve tumor-targeting delivery agents, employed pancreatic targeting CKAAKN peptide to prepare peptide-functionalized amphiphilic hyaluronic acid–vitamin E succinate polymer (CKAAKN–HA–VES) delivering ultra-small superparamagnetic...
Abstract One of the characteristics leukemia is that it contains multiple rearrangements signal transduction genes and overexpression non-mutant genes, such as transcription factors. As an important regulator hematopoietic stem cell development erythropoiesis, LMO2 considered effective carcinogenic driver in T lines a marker poor prognosis patients with AML normal karyotype. LDB1 key factor transformation thymocytes into T-ALL induced by LMO2, enhances stability related proteins leukemia....
Many species of the Urticaceae family are important cultivated fiber plants that known for their economic and industrial values. However, secondary metabolite profiles associated biosynthetic mechanisms have not been well-studied. Using Laportea bulbifera as a model, we conducted widely targeted metabolomics, which revealed 523 metabolites, including unique accumulation flavonol glycosides in bulblet. Through full-length transcriptomic RNA-seq analyses, related genes flavonoid biosynthesis...
Membranous nephropathy (MN) is a common immune-mediated glomerular disease that requires the development of safe and highly effective therapies. Celastrol (CLT) has shown promise as therapeutic molecule candidate, but its clinical use currently limited due to off-target toxicity. Given excess levels reactive oxygen species (ROS) contributing podocyte damage key driver MN progression end-stage renal disease, we rationally designed ROS-responsive cationic polymeric nanoparticles (PPS-CPNs)...
Proper control of inflammatory responses is essential for embryonic development, but the underlying mechanism poorly understood. Here, we show that under physiological conditions, inactivation ISG15, an inflammation amplifier, associated with interaction Beclin 1 (Becn1), via its evolutionarily conserved domain, STAT3 in major fetal hematopoietic organ mice. Conditional loss Becn1 caused sequential dysfunction and exhaustion liver stem cells, leading to lethal cell-biased hematopoiesis...
Strain Q3-56T, isolated from Arctic tundra soil, was found to be a Gram-stain-negative, yellow-pigmented, oxidase- and catalase-positive, non-motile, non-spore-forming, rod-shaped aerobic bacterium. Q3-56T grew optimally at pH 7.0 28 °C. The strain could tolerate up 1 % (w/v) NaCl with optimum growth in the absence of NaCl. not sensitive oxacillin ceftazidime. Phylogenetic analysis based on 16S rRNA gene sequences indicated that belonged genus Dyadobacter. showed highest sequence...
HomePlant DiseaseVol. 107, No. 7First Report of Epicoccum mackenziei Causing Dark Brown Spot Tea Leaf in Guizhou Province, Southwestern China PreviousNext DISEASE NOTE OPENOpen Access licenseFirst ChinaJ. Zhang, Q. X. Yin, S. L. Jiang, D. Li, Tang, Y. Ma, P. Wang, and Z. ChenJ. ZhangKey Laboratory Green Pesticide Agricultural Bioengineering, Ministry Education, University, Guiyang, Guizhou, China, YinKey JiangKey LiKey TangKey MaKey WangKey Wang†Corresponding authors: Chen; E-mail Address:...
This paper considers the problem associated with segmentation of trabecular bone image obtained from micro-computed tomography (microCT). The morphometric indices a 3D image, which are strength, may play an important clinical role in early predictions osteoporosis onset and longitudinal studies different medical treatments for osteoporosis. Correct estimation morphologic parameters requires accurate images. In present approach, connectivity-preserving threshold algorithm, connectivity stable...
Solid pseudopapillary neoplasm (SPN) of the pancreas is a low-grade malignant that accounts for ~5% cystic pancreatic tumors and ~0.9‑2.7% exocrine tumors. The transcription profiling data (GSE43795) 14 SPN 6 control samples were downloaded from Gene Expression Omnibus (GEO) database. Using Limma package, Student's t‑tests performed to identify differentially expressed genes (DEGs) between [with following criterion: False discovery rate (FDR)<0.01 log2 fold‑change (FC)≥3]. Pathway functional...
A Gram-stain-negative, rod-shaped, and aerobic bacterium, strain 16-35-5 T , was isolated from Collins Glacier front soil the Fildes Peninsula, Antarctica. The bacterium grew optimally at 28 °C, pH 7.0 in presence of 0–4.0 % (w/v) NaCl. On basis results 16S rRNA gene sequence phylogenetic analyses, it concluded that represented a member genus Acidovorax had highest similarities with anthurii CFBP 3232 (96.48 %). genome is 4.2 Mb long DNA G+C content 66.3 mol%. Average nucleotide identity...
Delayed-or non-healing wounds caused by trauma, surgical procedures, acute diseases, or chronic and proli-ferating scar have a serious impact on patients' quality of life increase the economic psychological burden their families. Therefore, how to accelerate wound healing obtain satisfactory aesthetic results is great concern researchers an urgent clinical problem be solved. In recent years, mechanisms Chinese medicinal materials in accelerating inhi-biting formation regulating cytokines...
A rod-shaped, Gram-stain-negative, non-motile and aerobic bacterium, designated Q8-18 T , was isolated from soil of glacier foreland in Austre Lovénbreen, Arctic, subjected to a polyphasic taxonomic study. Strain grew optimally at 20 °C, pH 5.0–8.0 the presence 0–1.0 % (w/v) NaCl. Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain belonged family Sphingobacteriaceae . showed highest sequence similarity Pedobacter mendelii CCM 8685 (96.8%), lithocola 8691 roseus...