A5067523933- Mitochondrial Function and Pathology
- Genetics, Aging, and Longevity in Model Organisms
- Autophagy in Disease and Therapy
- DNA Repair Mechanisms
- Signaling Pathways in Disease
- Genetics and Neurodevelopmental Disorders
- Nuclear Receptors and Signaling
- Hippo pathway signaling and YAP/TAZ
- Evolution and Genetic Dynamics
- Chromatography in Natural Products
- CRISPR and Genetic Engineering
- Infectious Diseases and Tuberculosis
- Amyotrophic Lateral Sclerosis Research
- Genetic Neurodegenerative Diseases
- Plant-based Medicinal Research
- Parkinson's Disease Mechanisms and Treatments
- Bacterial Infections and Vaccines
- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Molecular Biology Techniques and Applications
- DNA and Nucleic Acid Chemistry
- Genetic Mapping and Diversity in Plants and Animals
- Microbial Metabolic Engineering and Bioproduction
- Epigenetics and DNA Methylation
- Bacteriophages and microbial interactions
The University of Queensland
2017-2024
Park Centre for Mental Health
2018-2024
Guiyang Medical University
2022
Affiliated Hospital of Guizhou Medical University
2022
Soochow University
2022
Guizhou University
2020
Allen Institute for Brain Science
2019
Queens University
2017
Shanghai Ocean University
2013
The evolutionarily conserved Hippo (Hpo) signaling pathway plays a pivotal role in organ size control by balancing cell proliferation and death. Here, we reported the identification of Par-1 as regulator Hpo using gain-of-function EP screen Drosophila melanogaster. Overexpression elevated Yorkie activity, resulting increased target gene expression tissue overgrowth, while loss diminished reduced size. We demonstrated that par-1 functioned downstream fat expanded upstream hpo salvador (sav)....
Corydalis yanhusuo W.T. Wang alkaloids are mainly divided into three categories: protoberberine, prototropine and aporphine alkaloids. Therefore, we have taken account these alkaloid contents when extracting purifying crude drugs, which is essential for the quality control of C. its derivative products. Herein, investigated feasibility Q-marker uniform design method in optimization extraction purification yanhusuo. In this study, Q-marker-based comprehensive scoring (CS) methods were used to...
Abstract Caenorhabditis elegans is one of the most popular model organisms used to genetically dissect complex biological phenomena. One common technique routinely in C. laboratory generation strains carrying combinations genetic mutations via classical crosses. Here, we have developed a simple and convenient application quickly identify useful markers (phenotypical fluorescent) their chromosomal positions aid development cross strategies. The user-friendly software identifies prioritizes...
Abstract In virtually all eukaryotes, the mitochondrial genome (mitochondrial DNA, mtDNA) encodes proteins necessary for oxidative phosphorylation (OXPHOS) and RNA machinery required their synthesis inside mitochondria. Appropriate regulation of mtDNA copy number expression is essential ensuring correct stoichiometric formation OXPHOS complexes assembled from both nuclear- mtDNA-encoded subunits. The mechanisms are not completely understood but to organismal viability lifespan. Here, using...
Abstract Epigenetic regulation of activity-induced gene expression involves multiple levels molecular interaction, including histone and DNA modifications, as well mechanisms repair. Here we demonstrate that the genome-wide deposition Inhibitor growth family member 1 (ING1), which is a central epigenetic regulatory protein, dynamically regulated in response to activity primary cortical neurons. ING1 knockdown leads decreased genes related synaptic plasticity, subunit calcineurin, Ppp3r1 . In...
Abstract In multiple species, certain tissue types are prone to acquiring greater loads of mitochondrial genome (mtDNA) mutations relative others, however the mechanisms that drive these heteroplasmy differences unknown. We found conserved PTEN-induced putative kinase (PINK1/PINK-1) and E3 ubiquitin-protein ligase parkin (PDR-1), which required for autophagy (mitophagy), underlie stereotyped in a deleterious mutation (ΔmtDNA) between major somatic tissues Caenorhabditis elegans . demonstrate...
Ligustilide is a bioactive component of the traditional Chinese herb Angelica sinensis that exhibits analgesic, anti-inflammatory, anticancer, neuroprotection, and anti-atherosclerosis pharmacological activities. Herein, role ligustilide in intracerebral hemorrhage-induced cardiac damage has been assessed. An autologous blood injection was used to induce hemorrhage CD-1 mice resulted an increase systolic diastolic pressure. Intraperitoneal administration reduced pressure, decreased plasma...
It was to investigate the targeted therapeutic effect of methylprednisolone (MPS) composite nanoparticles (NPs) on tuberculous meningitis (TBM) in rats. A total 180 special pathogen-free (SPF) Sprague Dawley (SD) rats (male) were randomly and equally assigned normal control group, TBM infection treatment group. Those group injected with Mycobacterium tuberculosis suspension via tail vein. After model established, intraperitoneally methylprednisolone-nano sterically stabilized liposomes...