A5011091303- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Endometrial and Cervical Cancer Treatments
- Chronic Lymphocytic Leukemia Research
- Cervical Cancer and HPV Research
- Lung Cancer Treatments and Mutations
- Viral-associated cancers and disorders
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Colorectal and Anal Carcinomas
- Lung Cancer Research Studies
- Circular RNAs in diseases
- Ovarian cancer diagnosis and treatment
- Radiomics and Machine Learning in Medical Imaging
- Peptidase Inhibition and Analysis
- Hepatitis C virus research
- T-cell and Retrovirus Studies
- Cancer-related molecular mechanisms research
- Hepatitis B Virus Studies
- Lung Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- Biosimilars and Bioanalytical Methods
- Gastric Cancer Management and Outcomes
- Nanoplatforms for cancer theranostics
Peking University
2014-2024
Peking University Cancer Hospital
2014-2024
Fudan University Shanghai Cancer Center
2015-2024
First Affiliated Hospital of Jiangxi Medical College
2024
Nanchang University
2024
Shenzhen University
2024
Shanghai Medical College of Fudan University
2017-2023
NIHR CRUK Experimental Cancer Medicine Centre
2023
University of Southampton
2023
Cancer Research UK
2023
Hepatitis B virus (HBV) reactivation is a serious complication for patients with lymphoma treated rituximab-containing chemotherapies, despite lamivudine prophylaxis treatment. An optimal prophylactic antiviral protocol has not been determined.To compare the efficacy of entecavir and in preventing HBV seropositive hepatitis surface antigen untreated diffuse large B-cell receiving chemotherapy treatment rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone (R-CHOP).Randomized,...
Ovarian cancer is the malignant tumor of female reproductive system with highest fatality rate. Tolerance to chemotherapeutic drugs such as paclitaxel (PTX) occurring in very early stage one important factors poor prognosis ovarian cancer. Herein, we aim study dysregulation a particular circular RNA (circRNA), circCELSR1 (hsa_circ_0063809), and its role progression PTX resistance The high expression PTX-resistant tissues cells (SKOV3/PTX HeyA-8/PTX) was determined by microarray analyses...
Abstract The aberrant expression of long noncoding RNAs (lncRNAs) has been reported frequently in specific cancers, including high-grade serous ovarian cancer (HGSOC). purpose the present study was to explore clinical significance and underlying mechanisms a significantly dysregulated lncRNA (NEAT1) HGSOC. Our results showed that elevated NEAT1 human HGSOC specimens correlated with poor prognosis. Functional experiments demonstrated knockdown prohibited cell proliferation invasion vitro...
Introduction: The activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) continues to convey inferior survival despite efforts enhance outcomes with novel R-CHOP combinations. Phase II studies have suggested that the addition immunomodulatory agent lenalidomide could ameliorate poor prognostic effect ABC phenotype and improve treatment outcome in this subgroup patients. Methods: global phase III ROBUST trial (NCT02285062) is first compare lenalidomide/R-CHOP (R2-CHOP)...
An increasing number of studies have clarified the functional roles RNA-binding proteins (RBPs) in driving post-transcriptional mechanisms cancer progression. In this study, we integrated data from RBP database and Gene Expression Omnibus (GEO) with RNA sequencing (RNA-seq) 10 ovarian tissues 8 normal identified an RBP, CUGBP- ETR-3-like family 2 (CELF2). We found that CELF2 expression was downregulated positively correlated overall survival (OS) progression-free (PFS) patients cancer....
One major characteristic of tumor cells is the aberrant activation epigenetic regulatory elements, which remodel transcriptome and ultimately promote cancer progression drug resistance. However, oncogenic functions mechanisms ovarian (OC) remain elusive. Here, super-enhancer (SE) elements that are aberrantly activated in OC identified it found SEs drive relative specific expression transcription factor KLF5 patients poly(ADP-ribose) polymerase inhibitor (PARPi)-resistant patients. associated...
Abstract Background The purpose of the study was to investigate expression and prognostic value STAT3 in diffuse large B-cell lymphoma (DLBCL). Methods Seventy-four DLBCL patients from 2001 2007 were reviewed study. their tumor tissues examined using immunohistochemistry (IHC) method, evaluated for its association with clinicopathological parameters. Results Strong nuclear staining phosphorylated-STAT3 tyr705 (P-STAT3) observed 19 cases (25.7%) 24 (32.4%), respectively, levels highly...
Programmed death-ligand 1 (PD-L1) was expressed in various tumors and antibodies targeting its receptor programmed cell death-1 (PD-1) are emerging cancer therapeutics. This study designed to evaluate the expression of PD-L1 correlation with clinicopathologic features clinical outcomes ovarian clear carcinoma (OCCC).The measured by tissue-microarray-based immunohistochemistry from 122 eligible patients diagnosed OCCC. The associations progression-free survival (PFS) overall (OS) were...
Abstract Dysregulation of small nucleolar RNA host gene 6 (SNHG6) exerts critical oncogenic effects and facilitates tumourigenesis in human cancers. However, little information about the expression pattern SNHG6 ovarian clear cell carcinoma (OCCC) is available, contributions this long non‐coding to progression OCCC are unclear. In present study, we showed via quantitative real‐time PCR that was abnormally up‐regulated tissues relative unpaired normal tissues. High correlated with vascular...
Background: MicroRNAs contribute to chemotherapy response in different types of cancer. We hypothesized that plasma miRNAs are potentially associated with patients metastatic breast Patients and Methods: Fourteen candidate microRNAs were chosen from the literature, their levels measured by quantitative polymerase chain reaction (PCR). Forty cancer as training groups. The potential significant validated another 103 samples. Results: In set, we identified 3 (miR-200a, miR-210, miR-451)...
Abstract Dendritic cells (DC) are potent antigen‐presenting that can present tumor antigens chaperoned by heat shock proteins (HSPs), while local hyperthermia (LHT) increase the expression of HSPs. In this study, we determine if intratumoral injection immature DC after LHT (LHT+IT‐DC) induces systemic antitumor immunity in patients with advanced melanoma, and investigate potential immunological mechanisms involved treatments. Patients were randomly assigned to administration autologous...
Ovarian carcinosarcoma (OCS) accounts for high mortality and lacks effective therapeutic methods. So far, we lack reliable biomarkers capable of predicting the risk aggressive course disease. Programmed death ligand-1 (PD-L1) is expressed in various tumors, antibodies targeting its receptor programmed cell 1 (PD-1) are emerging cancer therapeutics. This study was designed to evaluate expression PD-L1 intratumoral CD8+ T lymphocytes by immunohistochemistry from 19 OCS patients who underwent...
The data regarding a transposed ovary in intensity-modulated radiotherapy (IMRT) are not sufficient. Here we aim to investigate the adequate dose constraint of ovarian transposition before cervical cancer patients. This was retrospective analysis 118 patients with who received radical hysterectomy and pelvic irradiation from April 2012 July 2017. A total 105 underwent IMRT limited radiation ovaries; 48 these unilateral limitation, while 57 bilateral limitations. Patient follow up sex hormone...
To investigate the prognostic value of six lymph nodes (LNs) staging systems: TNM pN stage, 2018 Federation International Gynecology and Obstetrics (FIGO) number positive LNs (PLN), negative (NLN), metastatic LN ratio (LNR), log odds (LODDS) in cervical squamous cell carcinoma (CSCC) patients following radical surgery.The records 3,732 CSCC who underwent surgery between 2006 2014 were retrospectively reviewed. We divided variables into different groups by applying tree-based recursive...
Midline NK/T-cell lymphoma nasal-type is an aggressive neoplasm with poor prognosis in most instances. To improve the treatment outcome, we have tried using L-asparaginase based regimen as salvage plus radiation CHOP failures, and report here therapeutic results prognostic factors.From March 1992 to January 2005, 46 Chinese patients midline were initially treated first-line chemotherapy. The who failed regimens altered receive regimen. All received primary involved-field after...
Uterine carcinosarcoma (UCS) shared the same staging system with endometrial carcinoma in International Federation of Gynecology and Obstetrics 2009. The aim present study was to compare clinicopathological prognostic characteristics between UCS grade 3 endometrioid (G3EC). A retrospective analysis 60 115 G3EC patients initial treatment at Department Fudan University Shanghai Cancer Center February 2006 August 2013. Chi-square used differences variables. Prognostic factors were determined...
Adjuvant treatment remains a controversial issue for intermediate-risk cervical cancer. The aim of this study was to compare the prognosis patients who underwent no adjuvant treatment, pelvic radiotherapy alone, or concurrent chemoradiotherapy after radical hysterectomy intermediate-risk, early-stage cancer.Patients with stage IB1-IIA2 (FIGO 2009) squamous cell carcinoma treated and lymph node dissection, negative nodes, surgical margins, parametria, had combined intermediate risk factors as...
Ovarian cancer is an aggressive tumor in women with high mortality. Paclitaxel (PTX) can be used for the chemotherapy of ovarian cancer. Here, roles circular_0061140 (circ_0061140) PTX sensitivity and malignant progression are unveiled.The expressions circ_0061140, microRNA-136 (miR-136) chromobox 2 (CBX2) mRNA were detected by quantitative real-time polymerase chain reaction (qRT-PCR). Protein expression was determined western blot. The half maximal inhibitory concentration (IC50)...
RBC based micro-vehicles were successfully fabricated for hypoxia activated O<sub>2</sub> precise delivery under 980 nm laser irradiation. Interestingly, owing to alleviating, the chemotherapy enhancement of PTX ovarian tumor was realized.