A5053499506- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cancer-related molecular mechanisms research
- Cervical Cancer and HPV Research
- PARP inhibition in cancer therapy
- Radiomics and Machine Learning in Medical Imaging
- DNA Repair Mechanisms
- AI in cancer detection
- Colorectal and Anal Carcinomas
- RNA modifications and cancer
- RNA Research and Splicing
- Digital Imaging for Blood Diseases
- MRI in cancer diagnosis
- Immunotherapy and Immune Responses
- Uterine Myomas and Treatments
- Cancer Research and Treatments
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Medicinal Plant Pharmacodynamics Research
- Cancer Genomics and Diagnostics
- Cancer Mechanisms and Therapy
- Mycobacterium research and diagnosis
- Image Processing Techniques and Applications
- Molecular Biology Techniques and Applications
- Renal cell carcinoma treatment
Fudan University Shanghai Cancer Center
2018-2025
Shanghai Medical College of Fudan University
2019-2025
Second Xiangya Hospital of Central South University
2025
Central South University
2025
Key Laboratory of Guangdong Province
2023
Jinshan Hospital of Fudan University
2022
Fudan University
2020
First Affiliated Hospital of Sichuan Medical University
2016
Yangzhou University
2014-2015
Nanjing Medical University
2013-2014
Long non-coding RNAs (lncRNAs) are recently identified regulators in tumorigenesis and tumour progression. BRAF-activated lncRNA (BANCR) is overexpressed melanoma has a potential functional role cell migration. However, little known concerning the of BANCR development colorectal cancer (CRC). The current study examined expression 60 pairs CRC matched adjacent normal tissues. quantitative polymerase chain reaction results showed that was frequently tissues this overexpression found to...
Long non‑coding RNAs (lncRNAs) are novel regulators in cancer biology. BRAF‑activated lncRNA (BANCR) is overexpressed melanoma and has a potential functional role cell migration. However, little known about the of BANCR development papillary thyroid carcinoma (PTC). In present study, expression was examined six pairs PTC matched adjacent normal tissues. The results revealed that levels were significantly higher tissues IHH‑4 cells compared with controls. Knockdown inhibited proliferation...
Weakly supervised whole slide image classification is usually formulated as a multiple instance learning (MIL) problem, where each treated bag, and the patches cut out of it are instances. Existing methods either train an classifier through pseudo-labeling or aggregate features into bag feature attention mechanisms then classifier, scores can be used for instance-level classification. However, pseudo labels constructed by former contain lot noise, latter not accurate enough, both which...
An increasing number of studies have clarified the functional roles RNA-binding proteins (RBPs) in driving post-transcriptional mechanisms cancer progression. In this study, we integrated data from RBP database and Gene Expression Omnibus (GEO) with RNA sequencing (RNA-seq) 10 ovarian tissues 8 normal identified an RBP, CUGBP- ETR-3-like family 2 (CELF2). We found that CELF2 expression was downregulated positively correlated overall survival (OS) progression-free (PFS) patients cancer....
Abstract Background Homologous recombination deficiency (HRD) is a molecular biomarker for administrating PARP inhibitor (PARPi) or platinum-based (Pt) chemotherapy. The most well-studied mechanism of causing HRD pathogenic BRCA1/2 mutations, while phenotype also present in patients without alterations, suggesting other unknown factors. Methods targeted next-generation sequencing (GeneseeqPrime® HRD) was used to evaluate the scores 199 (Cohort I). In Cohort II, total 85...
Abstract Dysregulation of small nucleolar RNA host gene 6 (SNHG6) exerts critical oncogenic effects and facilitates tumourigenesis in human cancers. However, little information about the expression pattern SNHG6 ovarian clear cell carcinoma (OCCC) is available, contributions this long non‐coding to progression OCCC are unclear. In present study, we showed via quantitative real‐time PCR that was abnormally up‐regulated tissues relative unpaired normal tissues. High correlated with vascular...
Abstract Motivation Endometrial cancer is a prevalent gynecological malignancy that requires accurate identification of its molecular subtypes for effective diagnosis and treatment. Four with different clinical outcomes have been identified: POLE mutation, mismatch repair deficient, p53 abnormal, no specific profile. However, determining these typically relies on expensive gene sequencing. To overcome this limitation, we propose novel method utilizes hematoxylin eosin-stained whole slide...
Akkermansia muciniphila (AKK), classified as “lean bacteria,” has emerged a promising candidate for ameliorating metabolic disorders, including obesity, diabetes, and liver disease. In this study, we investigated the therapeutic potential of AKK to counteract dysfunctions induced by Olanzapine (OLZ), first-class antipsychotic known its high efficacy but also association with disturbances, particularly Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Previous studies have...
Liquid biopsy is a promising approach for early detection of gynecological malignancies. In the PERCEIVE-I study, Cancer cases (n = 249) and age-matched non-cancer controls are randomly divided into training test sets at 1:1 ratio. Data derived from multi-omics assays obtained including cell-free DNA methylation panel targeting ≈490 000 CpG sites, mutation comprising 168 genes, eight tumor protein markers. The results showed that model outperformed models, demonstrating higher sensitivity...
To investigate the prognostic value of six lymph nodes (LNs) staging systems: TNM pN stage, 2018 Federation International Gynecology and Obstetrics (FIGO) number positive LNs (PLN), negative (NLN), metastatic LN ratio (LNR), log odds (LODDS) in cervical squamous cell carcinoma (CSCC) patients following radical surgery.The records 3,732 CSCC who underwent surgery between 2006 2014 were retrospectively reviewed. We divided variables into different groups by applying tree-based recursive...
Preoperative identification of
Objective: We compared the prognostic accuracy of four lymph node (LN) staging systems - 2018 International Federation Gynecology and Obstetrics (FIGO) stage, number positive (PLN), metastatic ratio (LNR), log odds nodes (LODDS) in patients with node-positive cervical squamous cell carcinoma (CSCC) following radical surgery explored optimal choice for clinical applications. Materials methods: Data were retrospectively collected from 928 CSCC who underwent between 2006 2014 our center....
Numerous studies suggest an important role for copy number alterations (CNAs) in cancer progression. However, CNAs of long intergenic noncoding RNAs (lincRNAs) ovarian (OC) and their potential functions have not been fully investigated. Here, based on analysis The Cancer Genome Atlas (TCGA) database, we identified this study oncogenic lincRNA termed LINC00662 that exhibited a significant correlation between its CNA increased expression. overexpression is highly associated with malignant...
Cervical cancer is responsible for 10-15% of cancer-related deaths in women worldwide. In China, it the most common female genital tract. However, genomic profiles Chinese cervical patients remain unclear.A total 129 were enrolled this study (113 squamous, 12 adenocarcinoma, 2 adenosquamous, and neuroendocrine carcinoma). To classify clinical features molecular characteristics cancer, alterations 618 selected genes analyzed samples these patients, utilizing target next-generation sequencing...
In the study of deep learning classification medical images, models are applied to analyze aiming achieve goals assisting diagnosis and preoperative assessment. Currently, most research classifies predicts normal cancer cells by inputting single-parameter images into trained models. However, for ovarian (OC), identifying its different subtypes is crucial predicting disease prognosis. particular, need distinguish high-grade serous carcinoma from clear cell preoperatively through non-invasive...
High-grade serous ovarian cancer (HGSOC) is the leading cause of death among gynecological malignancies. This mainly attributed to its high rates chemoresistance. To date, few studies have investigated molecular mechanisms underlying this resistance treatment in patients. In study, we aimed explore these using bioinformatics analysis.We analyzed microarray data set GSE51373, which included 16 platinum-sensitive HGSOC samples and 12 platinum-resistant control samples. Differentially expressed...
Recent studies have showed that Small nucleolar RNA host genes (SNHGs) acted as a subset of long noncoding RNAs (lncRNAs) critical roles in human cancer carcinogenesis. However, the biological functions SNHGs clear cell renal carcinoma (ccRCC) not been fully investigated. In this study, we screened an oncogenic lncRNA termed SNHG6 using RNA-Seq data ccRCC from The Cancer Genome Atlas (TCGA). Quantitative real-time PCR was then used to demonstrate expression tissues. overexpression is highly...