A5100719359- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Head and Neck Surgical Oncology
- Neuroinflammation and Neurodegeneration Mechanisms
- Ferroptosis and cancer prognosis
- Alzheimer's disease research and treatments
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Neonatal and fetal brain pathology
- Endometrial and Cervical Cancer Treatments
- RNA modifications and cancer
- Cleft Lip and Palate Research
- Autophagy in Disease and Therapy
- Ovarian cancer diagnosis and treatment
- Epigenetics and DNA Methylation
- Fetal and Pediatric Neurological Disorders
- Craniofacial Disorders and Treatments
- Cerebrospinal fluid and hydrocephalus
Burning Rock Biotech (China)
2025
Shanghai Children's Medical Center
2023
First Affiliated Hospital of Zhengzhou University
2013-2021
Accumulating evidence suggests that long noncoding RNA (lncRNA) functions as a critical regulator in cancer biology. Here, we characterized the role of lncRNA PCED1B antisense 1 (PCED1B-AS1) glioblastoma (GBM). PCED1B-AS1 was notably upregulated GBM tissues and cell lines closely associated with larger tumor size higher grade. Patients high had shorter survival time than those low PCED1B-AS1. Functional experiments showed depletion significantly inhibited, while overexpression promoted...
BRAF-activated non-coding RNA (BANCR) is a long (lncRNA) that contributes to the initiation and development of many solid tumors, including melanoma. However, BANCR functions downstream mechanisms are largely unknown. In this study, we aim investigate how participates in proliferation migration malignant melanoma elucidate underlying mechanism process. We found expression was low melanocytic nevus human melanocytes but high tissues cell lines. Knockdown inhibited invasion, induced apoptosis....
Liquid biopsy is a promising approach for early detection of gynecological malignancies. In the PERCEIVE-I study, Cancer cases (n = 249) and age-matched non-cancer controls are randomly divided into training test sets at 1:1 ratio. Data derived from multi-omics assays obtained including cell-free DNA methylation panel targeting ≈490 000 CpG sites, mutation comprising 168 genes, eight tumor protein markers. The results showed that model outperformed models, demonstrating higher sensitivity...
Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) are promising for the treatment of Alzheimer’s disease (AD). However, their low rate migration and survival in brain limit clinical applicability. This study is designed to improve therapeutic potential hUC-MSCs by preincubating them with resveratrol, a natural polyphenol capable regulating cell destiny. Herein, we demonstrate that resveratrol preincubation enhances vitro , as well homing into hippocampus AD mice vivo . Moreover,...
Abstract Glioma is the most malignant and aggressive type of brain tumour with high heterogeneity mortality. Although some clinicopathological factors have been identified as prognostic biomarkers, individual variants risk stratification in patients lower grade glioma (LGG) not fully elucidated. The primary aim this study was to identify an efficient DNA methylation combination biomarker for prognosis LGG. We conducted a retrospective cohort by analysing whole genome data 646 LGG from TCGA...
Objective To observe the therapeutic effect of 65 cases ventriculo-peritoneal shunt,and analyse cause shunt system obstruction to reduce complications and improve efficacy.Methods retrospectively analyze first affiliated hospital Zhengzhou university from August 2010 March 2012.Results Sixty-five had clinical symptoms improved in varying degrees.Five a obstruction,including 2 ventricular end tube blockage,2 valve blockage,1 case peritoneal blockage.After replacing clogged device,5 patients...
Background: The goals of operative treatment for unilateral coronal synostosis (UCS) are to improve appearance and allow unrestricted brain growth. However, severe premature closure the suture, existing methods do not address compression or expand volume skull cavity. We report our retrospective experience with bilateral fronto-orbital advancement combined cranial vault release using a free-floating bone flap (CVR + FFBF) technique resulting changes in anterior asymmetry index (ACVAI)...