Chronic kidney disease (CKD) and several other catabolic conditions are characterized by increased circulating inflammatory cytokines, defects in IGF-1 signaling, abnormal muscle protein metabolism, progressive atrophy. In these conditions, no reliable treatments successfully block the development of mice with CKD, we found a 2- to 3-fold increase myostatin expression muscle. Its pharmacological inhibition subcutaneous injections an anti-myostatin peptibody into CKD (IC50 ~1.2 nM) reversed...

Problematic Internet Use (PIU) is a growing problem in Chinese adolescents. There are many risk factors for PIU, which found at school and home. This study was designed to investigate the prevalence of PIU potential among high students China.A cross-sectional conducted. A total 14,296 were surveyed four cities Guangdong province. assessed by 20-item Young Addiction Test (YIAT). Information also collected on demographics, family school-related usage patterns. Of students, 12,446 users. those,...

School bullying is an emerging problem in China. The present study aimed to measure the prevalence of behaviors among Chinese adolescents and examine association being bullied with family factors, school factors indicators psychosocial adjustment.A cross-sectional was conducted. A total 8,342 middle students were surveyed four cities Guangdong Province. Self-reports on involvement information regarding adjustment collected. Descriptive statistics multi-level logistic regression analysis used...

The fast fashion industry is criticized for its unsustainable development. With the rise of green economy and awakening consumers’ awareness sustainable consumption, more companies realize significance marketing in improving brand performance. However, it undeniable that many tend to take advantage information asymmetry cover up part their business activities through fake campaigns gain potential consumers. There a limited number studies investigating perception greenwashing, while naturally...

Abstract Seller reputation, generated by buyer feedback, is critical to fostering trust in online marketplaces. Marketplaces or sellers may choose compensate buyers for providing feedback. Signaling theory predicts that only of high‐quality products will reward truthful especially when a product lacks any feedback and the seller not established. We confirm these hypotheses using Taobao's reward‐for‐feedback mechanism. High‐quality products, without established are chosen rewards, which cause...

This article presents a welfare analysis of the vehicle quota system Shanghai, China. The empirical findings suggest that leads to both loss as result reduction in transactions and gain because less externality auto consumption. net effect depends on shadow price marginal externality, assumption lifetime, market conditions such consumers' intrinsic preference for vehicles. Compared progressive tax system, is effective control but more efficient improving social welfare.

In neurodegenerative diseases, microglial activation and neuroinflammation are essential for the control progression of diseases. Mitigating microglium-induced inflammation is one strategy hindering Ferulic acid (FA) an effective anti-inflammatory agent, but its potential role regulation mechanism in neuroinflammatory reactions have not been fully studied. this study, model was established by lipopolysaccharide (LPS), inhibitory effect FA on BV2 microglia The results showed that...

Ultraviolet (UV) radiation poses risks to both human health and organics. In response the urgent demand for UV-shielding across various applications, extensive endeavors have been dedicated developing materials, spanning from wide-band gap semiconductors organo-inorganic composite films. However, existing UV shielding though suitable daily use, fall short of meeting demands extreme conditions. this work, we incorporated CeO₂ as a absorber into Y₂O₃...

Abstract The impact of digital platforms on the implementation United Nations’ (UN) Sustainable Development Goals (SDGs), especially business sustainability micro, small and medium-sized enterprises (MSMEs), under different containment policies during after COVID-19 pandemic has not yet been studied in detail. Using detailed administrative data from Alibaba Group’s online on-demand food delivery platform, we found that platform contributed to security, wellbeing, employment MSMEs both...

Abstract The progressive depletion of skeletal muscle is a hallmark many types advanced cancer and frequently associated with debility, morbidity, mortality. Muscle wasting primarily mediated by the activation ubiquitin-proteasome system, which responsible for degrading bulk intracellular proteins. E3 ubiquitin ligases control polyubiquitination, rate-limiting step in but their direct involvement protein catabolism remains obscure. Here, we report full-length cloning E3α-II, novel “N-end...

Formoterol is a highly potent β2-adrenoceptor-selective agonist, which muscle growth promoter in many animal species. Myostatin/activin inhibition reverses skeletal loss and prolongs survival of tumor-bearing animals. The aim this investigation was to evaluate the effects combination soluble myostatin receptor ActRIIB (sActRIIB) β2-agonist formoterol cachectic Lewis lung carcinoma model. sActRIIB extremely effective reversing wasting associated with experimental cancer cachexia mice. Muscle...

To explore the effects of group singing therapy on depression symptoms and quality life patients with stable chronic obstructive pulmonary disease (COPD).Patients COPD were randomly allocated to intervention (n = 30) control groups 30). The received once a week for 24 sessions along routine health education, whereas only education. All administered Hospital Anxiety Depression Scale subscale (HADS-D) Clinical Questionnaire (CCQ). Data collected at baseline 1, 3, 6 months.Fifty-six...

Aim: Fear of childbirth (FOC) is an extreme state anxiety, distress and worry about childbirth. Despite its common occurrence, the prevalence risk factors for FOC are inadequately understood in northwestern region China. Purpose: This study aimed to examine fear a cohort pregnant women northwest Patients Methods: A total 922 healthy were included this cross-sectional study. Participants filled out questionnaire on socio-demographic characteristics, as well Childbirth Attitudes Questionnaire...

Purpose of Review: The aim this review is to summarize the role gastrointestinal microbiome (GM) in development type 2 diabetes mellitus (T2DM). Besides, we discuss feasibility applying FMT treatment T2DM and propose a series processes refine use T2DM. Recent Findings: metabolic disease which connected with GM. According many researches, GM can produce variety metabolites such as bile acid, short chain fatty acids, lipopolysaccharides trimethylamine oxide play an important metabolism. method...

Background Sex workers in China continue to engage unprotected sex acts that put them at risk for contracting HIV (Human Immunodeficiency Virus) and other STIs (Sexually Transmitted Infections). The purpose of this study was explore women’s work history, the context work, condom use, testing services, potential barriers use a sample FSWs (female workers) Guangzhou, China. Methodology/Principal Findings In-depth, semi-structured, face-to-face interviews were conducted with 24 Informants...

The C hinese passenger‐vehicle industry contains a large number of manufacturers. Some them are members big corporate groups centered around state owned enterprises. These relationships may facilitate collusion. This paper applies the non‐nested hypothesis test methodology to data on passenger vehicles identify whether price collusion exists within or across groups. Our empirical results support assumption Bertrand Nash competition in industry: We find no evidence for cross‐group policy...

Cervical cancer is associated with abnormal expression of multiple genes. Survivin and Bcl-2 proteins are apoptosis inhibitors. The tumor suppressor gene CD82, which encodes the protein KAI1, downregulated in cervical cancer, differentiation degree. We investigated levels three their correlation metastasis by comparing them different lesions. Immunohistochemistry was used to detect normal cervix, chronic cervicitis, intraepithelial neoplasia (CIN) lesions, cancer. relationships between type,...

This study compared the efficacy of Wijma Delivery Expectancy/Experience Questionnaire (W-DEQ) and Childbirth Attitudes (CAQ) in assessing fear childbirth (FOC) among hospitalized pregnant women, aiming to identify a practical screening tool. A total 184 women were recruited from Northwest Women's Children's Hospital using convenience sampling. Data collected through General Demographic Questionnaire, Fear Birth Scale (FOBS), W-DEQ, CAQ. Using FOBS as reference, diagnostic performance W-DEQ...

A growing body of evidence suggests that systemic hormones and peptide growth factors may exert their effects on cell differentiation in part through regulation the division cycle. We hypothesized thyroid hormone regulates terminal plate chondrocytes controlling cycle progression at G1/S restriction point. Our results support this hypothesis by demonstrating treatment epiphyseal with under chemically defined conditions arrest DNA synthesis onset differentiation, indicating is one factor...