A5018951212- Renal and related cancers
- Forest ecology and management
- Developmental Biology and Gene Regulation
- Early Childhood Education and Development
- Genetic and Kidney Cyst Diseases
- Plant Water Relations and Carbon Dynamics
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Urological Disorders and Treatments
- Musculoskeletal pain and rehabilitation
- Pluripotent Stem Cells Research
- Retinoids in leukemia and cellular processes
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Congenital heart defects research
- Remote Sensing and LiDAR Applications
- Animal Genetics and Reproduction
- Neuroscience of respiration and sleep
- Forest Insect Ecology and Management
- Reproductive tract infections research
- Health Systems, Economic Evaluations, Quality of Life
- Tree Root and Stability Studies
- Forest Management and Policy
- Autopsy Techniques and Outcomes
- Family Dynamics and Relationships
- Air Quality and Health Impacts
- Estrogen and related hormone effects
Jackson State University
2021-2025
The University of Texas Health Science Center at Houston
2025
Northeastern University
2024
Thomas Jefferson University Hospital
2022-2024
St Mary's Hospital
2024
Manchester University NHS Foundation Trust
2024
University of Manchester
2024
Genomics (United Kingdom)
2024
Swansea Bay University Health Board
2023
Monash University Malaysia
2022
Engagement of Toll-like receptors (TLRs) on macrophages leads to activation the mitogen-activated protein kinases (MAPKs), which contribute innate immune responses. MAPK activity is regulated negatively by phosphatases (MKPs). MKP-1, founding member this family dual-specificity phosphatases, has been implicated in regulating lipopolysaccharide (LPS) responses, but its role TLR-mediated responses vivo not defined. Here, we show that mice deficient MKP-1 were highly susceptible endotoxic shock...
The koala, the only extant species of marsupial family Phascolarctidae, is classified as 'vulnerable' due to habitat loss and widespread disease. We sequenced koala genome, producing a complete contiguous reference including centromeres. reveal that koala's ability detoxify eucalypt foliage may be expansions within cytochrome P450 gene family, its smell, taste moderate ingestion plant secondary metabolites in vomeronasal receptors. characterized novel lactation proteins protect young pouch...
ABSTRACT Grafting, together with tissue identification by monoclonal antibodies, has been used to study the allocation of Xenopus animal cap cells ectodermal or mesodermal lineages. Animal become responsive at stage and lose responsiveness induction at, just after, (depending on batch embryos). The ability vegetal yolky induce mesoderm disappears between stages 11. It is present 6– may exist before this. emergence competence respond , coupled fact that endoderm already capable this stage,...
The aim of the current study was to determine: prevalence low back pain (LBP) and associated disability; frequency consultation general practice; whether there were differences in management by age. We conducted a cross-sectional population Aberdeen city Cheshire County, UK. Participants 15,272 persons aged 25 years older. 1-month period LBP 28.5%. It peaked at age 41-50 years, but ages over 80 reported 1 4 persons. Older more likely consult, severe continued increase with Management...
The Early Devonian Rhynie hot spring system is the oldest known and of low sulphidation type. It extends for at least 1.5 km along a major fault zone defining western margin an outlier fluvial lacustrine sediments, plant-bearing sinters andesitic lavas. age sedimentation hydrothermal activity has been determined by palynological (Pragian) radio-metric (396 ± 12 Ma) techniques. half graben with complex stepped margin. rocks show intense alteration zone. main minerals are quartz, K-feldspar,...
Epidemiological studies have used various measures to characterize trihalomethane (THM) exposures, but the relationship of these indicators exposure biomarkers remains unclear. We examined temporal and spatial variability in baseline blood THM concentrations assessed between several (tap water concentration, water-use activities, multiroute metrics). measured activity residential tap from 150 postpartum women three U.S. locations. Blood ΣTHM [sum chloroform (TCM), bromodichloromethane...
Background: Genetic factors that influence Alzheimer's disease (AD) risk include mutations in TREM2 and allelic variants of Apolipoprotein E, influencing AD pathology the general population Down syndrome (DS).Evidence shows dysfunction choroid plexus may compromise blood-cerebrospinal fluid (CSF) barrier, altering secretory, transport immune function can affect pathology.Objective: To investigate genotype phenotype DS individuals relation to damage blood-CSF barrier leakage identify markers...
Abstract Sequence-based genetic testing identifies causative variants in ~ 50% of individuals with developmental and epileptic encephalopathies (DEEs). Aberrant changes DNA methylation are implicated various neurodevelopmental disorders but remain unstudied DEEs. We interrogate the diagnostic utility genome-wide array analysis on peripheral blood samples from 582 genetically unsolved identify rare differentially methylated regions (DMRs) explanatory episignatures to uncover candidate...
Brequinar sodium (BQR) prevents cell proliferation by virtue of its inhibition de novo pyrimidine biosynthesis. BQR is capable inhibiting immune responses in vitro and effective suppressing the development contact sensitivity adjuvant arthritis rodent models. Based on antiproliferative immunosuppressive capacity BQR, we have evaluated efficacy preventing allograft rejection utilizing experimental models heterotopic heart kidney orthotopic liver transplantation an MHC non-MHC mismatched...
Canonical β-catenin-mediated Wnt signaling is essential for the induction of nephron development. Noncanonical Wnt/planar cell polarity (PCP) pathways contribute to processes such as polarization and cytoskeletal modulation in several tissues. Although PCP components likely establish plane kidney tubulogenesis, whether effectors directly modulate actin cytoskeleton tubulogenesis unknown. Here, we investigated roles assembly during tubule morphogenesis Xenopus laevis zebrafish. We found that...
Axial spondyloarthropathy typically has its onset in early adulthood and can impact significantly on quality of life. In the UK, biologic anti-tumour necrosis factor therapy is recommended for patients who are unresponsive to non-steroidal anti-inflammatory drugs. There remain several unresolved issues about long-term safety life outcomes treatment axial spondyloarthropathy. Long-term "real-world" surveillance data required complement from randomised controlled trials. We conducting a...
Widespread paper birch (Betulapapyrifera Marsh.) mortality associated with the activity of bronze borer (Agrilusanxius Gory) was observed across northern Michigan in 1991. This occurred at two study sites on which growth has been intensively monitored since 1985. Recent warmer than normal growing seasons and lower moisture availability are statistically a reduction annual diameter growth. On one site 62% trees were dead 13% visibly declining; other site, although no dead, 25% declining....
SummaryThe testes of adult rats were exposed to 0–3000 r x-irradiation, and the animals killed 6 hours 21 days after treatment. The numbers type-A, intermediate, type-B spermatogonia, degenerating cells mitotic figures counted in fifty cross sections seminiferous tubules each testis.Statistical analyses showed that a curvilinear relationship exists between number type-A intermediate (a) dose administered (b) time irradiation.The survival curves for spermatogonia are indicative population...
The aim of this study was to analyze trends in rates obesity amongst Mississippi adults between 2017 and 2023 based on five health determinants: gender, education, age, race, socioeconomic status. We calculated standard errors using Microsoft Excel performed trend analysis Joinpoint Regression. Obesity prevalence among men showed a statistically significant increasing from 2023, with an Annual Percent Change 0.86%. Among college-level significantly increased by 2.33% per year. For most age...
Abstract We report a study on the specification of glomus, filtration device amphibian pronephric kidney, using an explant culturing strategy in Xenopus laevis. Explants presumptive mesoderm were dissected from embryos mid-gastrula to swimming tadpole stages. These explants cultured within ectodermal wraps and analysed by RT-PCR for presence Wilm’s Tumour-1 gene, xWT1, marker specific glomus at stages analysed, together with other mesodermal markers. show that is specified stage 12.5, same...