A5053531292- Genomics and Phylogenetic Studies
- Genetic and phenotypic traits in livestock
- Molecular Biology Techniques and Applications
- Animal Behavior and Reproduction
- Wildlife Ecology and Conservation
- Evolution and Paleontology Studies
- Genetic diversity and population structure
- Genetics, Aging, and Longevity in Model Organisms
- Evolution and Genetic Dynamics
- Reproductive Physiology in Livestock
- Genetics, Bioinformatics, and Biomedical Research
- RNA Research and Splicing
- Environmental DNA in Biodiversity Studies
- Genetic Mapping and Diversity in Plants and Animals
- Scientific Computing and Data Management
- T-cell and B-cell Immunology
- Gut microbiota and health
- Cancer-related molecular mechanisms research
- Chromosomal and Genetic Variations
- RNA and protein synthesis mechanisms
- Aquaculture disease management and microbiota
- Biochemical Analysis and Sensing Techniques
The University of Sydney
2017-2024
Ronin Institute
2024
The koala, the only extant species of marsupial family Phascolarctidae, is classified as 'vulnerable' due to habitat loss and widespread disease. We sequenced koala genome, producing a complete contiguous reference including centromeres. reveal that koala's ability detoxify eucalypt foliage may be expansions within cytochrome P450 gene family, its smell, taste moderate ingestion plant secondary metabolites in vomeronasal receptors. characterized novel lactation proteins protect young pouch...
Incomplete lineage sorting (ILS) makes ancestral genetic polymorphisms persist during rapid speciation events, inducing incongruences between gene trees and species trees. ILS has complicated phylogenetic inference in many lineages, including hominids. However, we lack empirical evidence that leads to incongruent phenotypic variation. Here, performed phylogenomic analyses show the South American monito del monte is sister of all Australian marsupials, although over 31% its genome closer...
Abstract Ninu (greater bilby, Macrotis lagotis ) are desert-dwelling, culturally and ecologically important marsupials. In collaboration with Indigenous rangers conservation managers, we generated the chromosome-level genome assembly (3.66 Gbp) sequences for extinct Yallara (lesser leucura ). We developed tested a scat single-nucleotide polymorphism panel to inform current future actions, undertake ecological assessments improve our understanding of genetic diversity in managed wild...
Abstract Background The biodiversity crisis and increasing impact of wildlife disease on animal human health provides impetus for studying immune genes in wildlife. Despite the recent boom genomes species, are poorly annotated nonmodel species owing to their high level polymorphism complex genomic organisation. Our research over past decade a half Tasmanian devils koalas highlights importance genomics accurate annotations investigate Given this, we have increasingly been asked minimum levels...
Antechinus are a genus of mouse-like marsupials that exhibit rare reproductive strategy known as semelparity and also naturally develop age-related neuropathologies similar to those in humans. We provide the first annotated antechinus reference genome for brown (Antechinus stuartii). The is 3.3 Gb size with scaffold N50 73Mb 93.3% complete mammalian BUSCOs. Using bioinformatic methods we assign scaffolds chromosomes identify 0.78 Mb Y-chromosome scaffolds. Comparative genomics revealed...
Biodiversity is declining globally, and Australia has one of the worst extinction records for mammals. The development sequencing technologies means that genomic approaches are now available as important tools wildlife conservation management. Despite this, genome sequences only 5% threatened Australian species. Here we report first reference woylie (Bettongia penicillata ogilbyi), a critically endangered marsupial from Western Australia, within Potoroidae family. was generated using Pacific...
The numbat (
Abstract Over the past decade, development of genetic and genomic tools for conservation management has come forward in leaps bounds. Once considered a ‘nice to have’, data are fast becoming an essential tool informing managing translocations. However, due complexity field, easily using decision‐making monitoring remains beyond reach most managers biologists. In May 2020, we launched Threatened Species Initiative (TSI), programme designed generate resources Australia's threatened species....
Successful captive breeding programs are crucial to the long-term survival of many threatened species. However, pair incompatibility (breeding failure) limits sustainability populations. Understanding whether drivers this behavioral, genetic, or a combination both, is improving programs. We used 28 years pairing data from San Diego Zoo koala colony, plus genetic analyses using both major histocompatibility complex (MHC)-linked and non-MHC-linked microsatellite markers, show that non-genetic...
Abstract Interindividual variation at genes known to play a role in reproduction may impact reproductive fitness. The Tasmanian devil is an endangered Australian marsupial with low genetic diversity. Recent work has shown concerning declines productivity both wild and captive populations over time. Understanding whether functional diversity exists the key first step identifying that influence productivity. We characterized single nucleotide polymorphisms (SNPs) 214 involved 37 devils. Twenty...
Abstract The numbat ( Myrmecobius fasciatus ) is a critically endangered Australian marsupial, and the last surviving member of Myrmecobiidae family. regularly undergoes torpor unique amongst marsupials as it only diurnal termitivorous species. Here we sequenced first draft genome using 10× Genomics chromium linked-read technology, resulting in 3.42 Gbp with scaffold N50 223 Kbp. A global transcriptome from liver, lung tongue was also generated to aid annotation Fgenesh++, identifying 21,465...
Abstract Antechinus are a genus of mouse-like marsupials that exhibit rare reproductive strategy known as semelparity and also naturally develop age-related neuropathologies similar to those in humans. We provide the first annotated antechinus reference genome for brown ( stuartii ). The is 3.3Gb size with scaffold N50 73Mb 93.3% complete mammalian BUSCOs. Using bioinformatic methods we assign scaffolds chromosomes identify 0.78Mb Y-chromosome scaffolds. Comparative genomics revealed...
<title>Abstract</title> The Ninu (Greater bilby, <italic>Macrotis lagotis</italic>) is a desert-dwelling, culturally and ecologically important marsupial. In collaboration with Indigenous rangers conservation managers, we generated the first chromosome-level genome assembly (3.66 Gbp) sequences for extinct Yallara (lesser leucura</italic>) to understand their biology guide management. Resequenced genomes (temperate Ninu=6; semi-arid Yallara=4) revealed two major population crashes during...
Abstract Biodiversity is declining globally, and Australia has one of the worst extinction records for mammals. The development sequencing technologies means that genomic approaches are now available as important tools wildlife conservation management. Despite this, genome sequences only 5% threatened Australian species. Here we report first reference woylie ( Bettongia penicillata ogilbyi ), a critically endangered marsupial from Western Australia, within Potoroidae family. was generated...
Successful captive breeding programs are crucial to the long-term survival of threatened species. However, pair incompatibility limits sustainability many populations. Understanding whether drivers this behavioural or genetic, a combination both, is improving programs. We used twenty-eight years pairing data from San Diego Zoo koala colony, plus genetic analyses using both MHC-linked and non-MHC-linked microsatellite markers, show that determinants can influence mating success. Male age was...
Successful captive breeding programs are crucial to the long-term survival of threatened species. However, pair incompatibility limits sustainability many populations. Understanding whether drivers this behavioural or genetic, a combination both, is improving programs. We used twenty-eight years pairing data from San Diego Zoo koala colony, plus genetic analyses using both MHC-linked and non-MHC-linked microsatellite markers, show that determinants can influence mating success. Male age was...