A5101551628- Circular RNAs in diseases
- Extracellular vesicles in disease
- Tryptophan and brain disorders
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Aortic Disease and Treatment Approaches
- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
- interferon and immune responses
- RNA Research and Splicing
- Microbial metabolism and enzyme function
- Alzheimer's disease research and treatments
- Venous Thromboembolism Diagnosis and Management
- Infective Endocarditis Diagnosis and Management
- Angiogenesis and VEGF in Cancer
- RNA modifications and cancer
- Inflammasome and immune disorders
- Toxoplasma gondii Research Studies
- Microtubule and mitosis dynamics
- Drug Transport and Resistance Mechanisms
- Aortic aneurysm repair treatments
- Oral and Maxillofacial Pathology
- Epigenetics and DNA Methylation
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Interference and Gene Delivery
Jinzhou Medical University
2012-2024
Hubei University of Chinese Medicine
2024
First People's Hospital of Jingzhou
2016
// Qianze Dong 1 , Lin Fu Yue Zhao Yaming Du 2 Qingchang Li Xueshan Qiu Enhua Wang Department of Pathology, First Affiliated Hospital and College Basic Medical Science, China University, Shenyang, Cardiovascular Thoracic Surgery, The Jinzhou Jinzhou, Correspondence to: Wang, email: wangenhuacmu@hotmail.com Keywords: Rab11a, Hippo, YAP, non-small cell lung cancer, proliferation Received: October 26, 2016 Accepted: January 09, 2017 Published: February 15, ABSTRACT an evolutionarily conserved...
Abstract Alzheimer's disease (AD) is the leading cause of dementia worldwide, with recent studies highlighting potential role immunogenic cell death (ICD) in pathogenesis this neurodegenerative disorder. A total 52 healthy controls and 64 patients AD were included. Compared to controls, exhibited 2392 differentially expressed genes (DEGs), which 1015 1377 upregulated downregulated genes, respectively. Among them, nine common identified by intersecting AD-related module DEGs ICD-associated...
TRIM32 is overexpressed in several human cancers. However, its expression pattern, biological characteristics and mechanisms non-small cell lung cancer (NSCLC) have not been reported.We examined protein 115 cases of NSCLC specimens. plasmid transfection siRNA knockdown was carried out lines. AnnexinV/PI JC-1 staining were performed to examine the change apoptosis mitochondrial membrane potential. Western blot used detect downstream proteins.We found that upregulated 69 positively correlated...
Deep vein thrombosis (DVT) is one of the most common circulating vascular diseases with an incidence ~0.1% worldwide. Although anticoagulant medication remains to be main therapeutic approach for patients DVT, existing thrombus and pulmonary embolisms still pose as a threat patient life. Therefore, effective targeted therapies need developed studies are required improve understanding this condition. Endothelial progenitor cells (EPCs) originate from bone marrow, located in peripheral blood...
HCRP1 has been reported to have tumor suppressive function. However, its expression pattern and function in human non-small cell lung cancer (NSCLC) remain obscure. This study aims explore clinical significance of NSCLC. Immunohistochemical results showed high protein normal bronchial epithelial tissue downregulated 47/98 specimens. downregulation correlated with stage (p = 0.0203), nodal status 0.0168), poor patient prognosis (log-rank, p 0.0076). Univariate analysis that TNM < 0.0001)...
Purpose: Exosomal microRNAs (miRNAs) play essential roles in the development of hepatocellular carcinoma (HCC).Nevertheless, role and mechanism exosomal miR-638 HCC remain largely unknown.Methods: Exosomes were isolated confirmed via transmission electron microscopy western blot.The abundances specificity protein 1 (SP1) measured quantitative reverse transcription polymerase chain reaction or blot.Cell proliferation was investigated by Cell Counting Kit-8, colony formation assay, apoptosis,...
Abstract Discoidin domain receptors 1 and 2 (DDR1 DDR2) are members of the receptor tyrosine kinases, which regulate fundamental cellular processes concerning proliferation, differentiation, adhesion, motility, apoptosis. The dysregulation these is linked to a number human diseases, including fibrotic disorders, atherosclerosis, cancer. However, there have been no studies that analyzed expression DDRs in ameloblastomas (ABs). In this study, we investigated level distribution both ABs...
Background Huanglian Jiedu decoction (HLJDD) is a classical herbal formula for treating inflammatory diseases with Traditional Chinese Medicine (TCM). However, the impacts of HLJDD on neuroinflammation and precise mechanisms involved remain poorly understood. Purpose In present study, was found to inhibit lipopolysaccharide (LPS) induced neuroinflammatory responses in BV2 microglia via regulating NLRP3 inflammasome activation. Materials Methods Anti-inflammatory activity evaluated ELISA...
Background: Alzheimer’s disease (AD) currently lacks effective disease-modifying treatments. Recent research suggests that ferroptosis could be a potential therapeutic target. Mendelian randomization (MR) is widely used method for identifying novel targets. Objective: Employ genetic information to evaluate the causal impact of ferroptosis-related genes on risk AD. Methods: 564 were obtained from FerrDb. We derived instrumental variables these using four brain quantitative trait loci (QTL)...
This study was to investigate the characteristics and related factors of postoperative drug-resistant bacteria infection (DRBI) in patients with acute Stanford A aortic dissection (AD) (AAAD) based on a two-fluid numerical simulation model (TFNS model). 50 AAAD admitted our hospital from July 2018 October 2020 were selected as research objects. The rolled into an group non-infection according whether DRBI occurred after surgery. There 21 infected 29 non-infected group. clinical data...