A5084529008- Gut microbiota and health
- Ginseng Biological Effects and Applications
- Mycobacterium research and diagnosis
- Clostridium difficile and Clostridium perfringens research
- Pharmacological Effects of Natural Compounds
- Microbial Natural Products and Biosynthesis
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Cancer-related molecular mechanisms research
- Pharmacogenetics and Drug Metabolism
- Marine Sponges and Natural Products
- Biocrusts and Microbial Ecology
- Algal biology and biofuel production
- Antibiotic Resistance in Bacteria
- Phenothiazines and Benzothiazines Synthesis and Activities
- Receptor Mechanisms and Signaling
- RNA and protein synthesis mechanisms
- Photosynthetic Processes and Mechanisms
- Caveolin-1 and cellular processes
- Chemical Reactions and Isotopes
- bioluminescence and chemiluminescence research
- RNA modifications and cancer
- Biochemical and Structural Characterization
- Nematode management and characterization studies
- Nitric Oxide and Endothelin Effects
Central South University
2016-2025
Xiangya Hospital Central South University
2016-2025
University of Florida
2018-2024
PharmacoGenetics (China)
2022-2023
National Clinical Research Center for Digestive Diseases
2020-2023
Hunan University
2022
Changsha University
2016
Abstract Considered one of the most devastating coral disease outbreaks in history, stony tissue loss (SCTLD) is currently spreading throughout Florida’s reefs and greater Caribbean. SCTLD affects at least two dozen different species has been implicated extensive losses cover. Here we show Pseudoalteromonas sp. strain McH1-7 broad-spectrum antibacterial activity against SCTLD-associated bacterial isolates. Chemical analyses indicated produces potential antibacterials, korormicin...
Dolastatin 10, a potent tubulin-targeting marine anticancer natural product, provided the basis for development of six FDA-approved antibody–drug conjugates. Through screening cyanobacterial Caldora penicillata environmental DNA libraries and metagenome sequencing, we identified its biosynthetic gene cluster. Functional prediction 10 enzymes encoded in 39 kb cluster supports dolastatin biosynthesis. The nonheme diiron monooxygenase DolJ was biochemically characterized to mediate terminal...
Mycosporine-like amino acids (MAAs) are a family of natural products that produced by variety organisms for protection from ultraviolet damage. In this work, we combined different bioinformatic approaches to assess the distribution MAA biosynthesis and identified putative gene cluster Nostoc linckia NIES-25 encodes short-chain dehydrogenase/reductase nonheme iron(II)- 2-oxoglutarate-dependent oxygenase (MysH) as potential new biosynthetic enzymes. Heterologous expression refactored clusters...
Background: Ginsenoside compound K (GC-K), generated from ginseng saponins bioconverted by gut microbiota, has potential anti-colorectal cancer (CRC) effects. Meanwhile, GC-K may interact with playing important roles in the occurrence and development of CRC. However, effects microbiota on preventive therapeutic CRC remain to be elucidated. Methods: The anti-CRC were evaluated an azoxymethane/dextran sulfate sodium (AOM/DSS)-induced colitis-associated Balb/c mice model under dosage 30 60...
ABSTRACT Ginsenoside compound K (GCK) has been proved to have great hypoglycemic effect pertinent gut microbiota. However, the improvement of high‐fat‐diet (HFD)‐induced type 2 diabetes (T2D) as well mechanism GCK mediated by microbiota is not well‐known. This study aimed investigate effects and on a HFD‐induced diabetic mouse model. pseudo‐germ free (GF) T2D mice model fecal transplantation (FMT) experiments were performed clarify role in GCK. Differential metabolites screened untargeted...
Panax notoginseng saponins (PNSs) are the major health-beneficial components of P. with very low oral bioavailability, which could be biotransformed by gut microbiota in vitro. However, vivo biotransformation PNS mediated is not well known. This study aimed to characterize metabolic profiles microbiota. The and yielded metabolites rat feces were identified relatively quantified ultra-performance liquid chromatography tandem/quadrupole time-of-flight mass spectrometry. Seventy-three had been...
Gut microbiota are significantly associated with the occurrence and development of inflammatory bowel disease (IBD). Panax notoginseng saponins (PNS) could be used for colitis to modulate gut microbiota. However, mechanism behind effects PNS on anti-colitis that pertinent is largely unknown. This study aimed evaluate explore involved as it related Results showed alleviated dextran sulfate sodium (DSS)-induced colitis. Meanwhile, after treatment, tight junction proteins were enhanced...
Bile acids (BAs) exert a profound influence on the body's pathophysiology by intricately shaping composition of gut bacteria. However, complex interplay between BAs and microbiota has impeded systematic exploration their impact intestinal Initially, we investigated effects 21 growth 65 bacterial strains in vitro. Subsequently, examined overall bacteria, both vivo The results unveiled distinct various different diverse impacts Mechanistically, inhibition occurs through accumulation these...
Abstract Background Most prostate cancer patients die from metastasis and lack accurate efficacious biomarkers to monitor the disease behavior, optimize treatment assess prognosis. Herein, we aimed identify meaningful lncRNA associated with metastatic progression. Methods By repurposing microarray probes, 11,624 lncRNAs in were obtained Gene Expression Omnibus database (GSE46691, N = 545; GSE29079, 235; GSE94767, 130). Weighted gene co-expression network analysis was applied determine...
Significance Aminoacyl-transfer RNA (tRNA) synthetases (aaRSs) are essential enzymes that mediate accurate expression of the genetic code. More than 96% analyzed species possess duplicated aaRSs genes, which presumed to encode canonical aaRSs. However, in this study, we show some these seemingly fact repurposed for deliberate mistranslation code, enabling organisms two amino acids using a single sense codon. This finding, along with abundance suggests codons may be more common previously...
Dietary capsaicin (CAP), the main irritant component in pepper, can reduce incidence of diabetes, while metformin (MET) is a first-line oral hypoglycemic drug. The purpose this study was to investigate whether CAP on effect MET pertinent gut microbiota. glucose and insulin tolerance diabetic rats were monitored. glycolipid metabolism analyzed by detecting blood biochemical parameters. Liver pathological changes observed Hematoxylin eosin (HE) staining. inflammatory cytokines intestinal tight...
Microbes are essential to the global ecosystem, but undesirable microbial growth causes issues ranging from food spoilage and infectious diseases harmful cyanobacterial blooms. The use of chemicals control has achieved significant success, while specific roles for a majority genes in remain unexplored. Here, we show inhibition species by targeting an enzyme biosynthesis branched-chain amino acids. Specifically, report biochemical, genetic, structural characterization dihydroxyacid...
Abstract Background Panax notoginseng saponins (PNS) as the main effective substances from P. with low bioavailability could be bio-converted by human gut microbiota. In our previous study, PNS metabolic variations mediated microbiota have been observed between high fat, protein (HF-HP) and plant fiber-rich (LF-PF) dietary subjects. this we aimed to correspondingly characterize relationship distinct microbial species metabolites. Methods Gut were collected HF-HP LF-PF healthy adults profiled...
Ginsenoside compound K (GC-K) potentially alleviates ulcerative colitis involved in gut microbiota, which is significantly associated with the occurrence and development of colitis. However, effect mechanism GC-K on anti-colitis relation to microbiota are not clear. This study focused prevention Dextran sulfate sodium (DSS)-induced mice pertinent microbiota.DSS was used establish a chronic mouse model. Body weight analysis, colon length measurement, HE staining, inflammatory factors levels...
The Tongmai Yangxin pill (TMYX) has potential clinical effects on no-reflow (NR); however, the effective substances and mechanisms remain unclear.This study evaluates cardioprotective molecular of TMYX against NR.We used a myocardial NR rat model to confirm effect mechanism action in alleviating NR. Sprague-Dawley (SD) rats were divided into Control (Con), sham, NR, (4.0 g/kg), sodium nitroprusside (SNP, 5.0 mg/kg), received their treatments once day for one week. In vitro studies isolated...