A5022897782- Plasma Applications and Diagnostics
- Nanoparticles: synthesis and applications
- Inhalation and Respiratory Drug Delivery
- Advanced Drug Delivery Systems
- biodegradable polymer synthesis and properties
- Gold and Silver Nanoparticles Synthesis and Applications
- Bacteriophages and microbial interactions
- Bacterial biofilms and quorum sensing
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Polymer Surface Interaction Studies
- Drug Solubulity and Delivery Systems
- Graphene and Nanomaterials Applications
- Bacterial Identification and Susceptibility Testing
- Surfactants and Colloidal Systems
- Microbial Inactivation Methods
- Nursing education and management
- Hydrogels: synthesis, properties, applications
- Cystic Fibrosis Research Advances
- Electrowetting and Microfluidic Technologies
- Analytical Methods in Pharmaceuticals
- Advanced Polymer Synthesis and Characterization
- Marine and coastal plant biology
- Advancements in Transdermal Drug Delivery
- vaccines and immunoinformatics approaches
University of Jordan
2013-2024
Queen's University Belfast
2012-2014
The potential application of phage therapy for the control bacterial biofilms has received increasing attention as resistance to conventional antibiotic agents continues increase. present study identifies antimicrobial synergy between bacteriophage T4 and a antibiotic, cefotaxime, via standard plaque assay and, importantly, in vitro eradication host strain Escherichia coli 11303. Phage-antibiotic (PAS) is defined phenomenon whereby sub-lethal concentrations certain antibiotics can...
Bacteria exist, in most environments, as complex, organised communities of sessile cells embedded within a matrix self-produced, hydrated extracellular polymeric substances known biofilms. Bacterial biofilms represent ubiquitous and predominant cause both chronic infections associated with the use indwelling medical devices such catheters prostheses. Such typically exhibit significantly enhanced tolerance to antimicrobial, biocidal immunological challenge. This renders them difficult,...
The use of atmospheric pressure nonthermal plasma represents an interesting and novel approach for the decontamination surfaces colonized with microbial biofilms that exhibit enhanced tolerance to antimicrobial challenge. In this study, influence jet, operated in a helium oxygen gas mixture under ambient pressure, was evaluated against Bacillus cereus, Staphylococcus aureus, Escherichia coli Pseudomonas aeruginosa. Within < 4 min exposure, complete eradication two gram-positive bacterial...
The main aim of this study was to determine the virucidal inactivation efficacy an in-house-designed atmospheric pressure, nonthermal plasma jet operated at varying helium/oxygen feed gas concentrations against MS2 bacteriophage, widely employed as a convenient surrogate for human norovirus.The effect variation percentage oxygen concentration in helium (He) carrier studied and found positively correlate with rate, indicating role reactive species (ROS) viral inactivation. rate constant...
The increasing challenge of antibiotic resistance requires not only the discovery new antibiotics, but also development alternative approaches. Herein, synergistic antibacterial activity silver nanoparticles and hydrogen peroxide combination is reported. Unlike bacteriostatic or slightly bactericidal achieved by using each agent alone, these two agents in combination, even at relatively low concentrations, resulted complete eradication both Gram negative Escherichia coli positive...
Apoptosis, programmed cell death pathway, is a vital physiological mechanism that ensures cellular homeostasis and overall well-being. In the context of cancer, where evasion apoptosis hallmark, overexpression anti-apoptotic proteins like Bcl2, Bcl-xL Mcl-1 has been documented. Consequently, these have emerged as promising targets for therapeutic interventions. The BCL-2 protein family central to plays significant importance in determining fate serving critical determinant this biological...
The aim of this study is to evaluate the contribution self-evaluation, professional status and several demographic factors in predicting burnout among nurses Jordan. This was performed on a stratified convenience sample 350 from 6 hospitals. Modified versions inventory, self-evaluation scale, scale were developed, validated used study. Burnout, are all found be at moderate levels. Furthermore, important predictors burnout. On other hand, although type hospital educational level associated...
A simple and reliable didactic laboratory has been developed to illustrate fundamental concepts of hydrophilicity, hydrophobicity, wetting, spreading phenomena for undergraduate students. The described includes preparation surfactant solutions at different concentrations applying droplets these on a hydrophobic surface followed by imaging the applied using cost-effective USB digital microscope connected computer. Contact-angle values were measured ImageJ, freely available image-processing...
We report a simple surface functionalization of glutathione-capped gold nanoclusters by hydrophobic ion pairing with alkylamine followed complete phase transfer to various organic solvents maintained colloidal stability and photoluminescence properties. The described hydrophobication enables efficient encapsulation into PLGA nanocarriers allowing their visualization inside cultured cells using confocal fluorescent microscopy. simplicity efficiency the protocols should extend biomedical...
The aim of this study was to evaluate the influence Na-bicarbonate as an effervescent agent on floating and sustained-release characteristics in 0.1 M HCl tablets made Eudragit E PO (EE) and/or L-100-55 (EL) matrix formers at different EE : EL weight ratios: 0 100, 25 75, 50 50, 75 25, 100 0. were by direct compression utilizing metronidazole a model drug. Effervescent with 50EE/50EL (w/w) showed best sustained drug release properties dissolution medium. corresponding noneffervescent...
The nature and kinetics of plasmid DNA damage after exposure to a kHz-driven atmospheric pressure nonthermal plasma jet has been investigated. Both single-strand break (SSB) double-strand (DSB) processes are reported here. While SSB had higher rate constant, DSB is recognized be more significant in living systems, often resulting loss viability. In helium-operated jet, adding oxygen the feed gas resulted rates DSB, which increased linearly with increasing content, up an optimum level 0.75%...
Minimum inhibitory concentration (MIC), minimum bactericidal (MBC), and biofilm eradication (MBEC) kill kinetics were established for vancomycin, rifampicin, trimethoprim, gentamicin, ciprofloxacin against the forming bacteria Staphylococcus epidermidis (ATCC 35984), aureus 29213), Methicillin Resistant (MRSA) 43300), Pseudomonas aeruginosa (PAO1), Escherichia coli (NCTC 8196). MICs MBCs determined via broth microdilution in 96‐well plates. MBECs studied using Calgary Biofilm Device. Values...
The ability to control the internal core architecture of polymeric microcapsules has a direct impact on their applications. However, this task, especially produce with high percentage mononuclear aqueous cores, proved be challenging. In work, and in continuation our previous studies, we report facile protocol prepare poly(D,L-lactide-co-glycolide) (PLGA) unprecedented (almost 100%) cores by phase separation method via adding alcohols. Different types alcohols (methanol, ethanol, propanol,...