A5020519408- Advancements in Transdermal Drug Delivery
- Ocular Surface and Contact Lens
- Dermatology and Skin Diseases
- Contact Dermatitis and Allergies
- Advanced Drug Delivery Systems
- Optical Coherence Tomography Applications
- Microwave-Assisted Synthesis and Applications
- Skin Protection and Aging
Queen's University Belfast
2014-2016
Czech Academy of Sciences, Biology Centre
2015
Transdermal drug delivery offers a number of advantages for the patient, due not only its non-invasive and convenient nature, but also factors such as avoidance first pass metabolism prevention gastrointestinal degradation. It has been demonstrated that microneedle arrays can increase compounds amenable to transdermal by penetrating skin's protective barrier, stratum corneum, creating pathway permeation dermal tissue below. Microneedles have extensively investigated in recent decades vaccine...
A commercial polymeric film (Parafilm M®, a blend of hydrocarbon wax and polyolefin) was evaluated as model membrane for microneedle (MN) insertion studies. Polymeric MN arrays were inserted into Parafilm M® (PF) also excised neonatal porcine skin. folded before the insertions to closely approximate thickness Insertion depths using optical coherence tomography (OCT) either force applied by Texture Analyser or group human volunteers. The obtained were, in general, slightly lower, especially...
A novel manufacturing process for fabricating microneedle arrays (MN) has been designed and evaluated. The prototype is able to successfully produce 14×14 MN easily capable of scale-up, enabling the transition from laboratory industry subsequent commercialisation. method requires custom design metal master templates silicone moulds using an injection moulding process. produced this was compared with centrifugation, traditional producing aqueous hydrogel-forming arrays. results proved that...
1A microwave (MW)-assisted crosslinking process to prepare hydrogel-forming microneedle (MN) arrays was evaluated. Conventionally, such MN are prepared using processes that includes a thermal step. Polymeric were poly(methyl vinyl ether-alt-maleic acid) crosslinked by reaction with poly(ethylene glycol) over 24 h at 80 °C. compare conventional the novel MW-assisted method. Infrared spectroscopy used evaluate degree, evaluating area of carbonyl peaks (2000-1500 cm-1). It shown that, process,...