A5102803680- Mycotoxins in Agriculture and Food
- Wheat and Barley Genetics and Pathology
- Aquatic Ecosystems and Phytoplankton Dynamics
- Pesticide Residue Analysis and Safety
- Plant and fungal interactions
- Biocrusts and Microbial Ecology
- Marine Toxins and Detection Methods
- Marine and coastal ecosystems
- Plant Disease Resistance and Genetics
- Bacillus and Francisella bacterial research
- Agricultural Development and Management
- Agricultural Research and Practices
- Insect and Pesticide Research
- Plant Pathogens and Resistance
- Plant Pathogens and Fungal Diseases
- Listeria monocytogenes in Food Safety
- Intramuscular injections and effects
- Agricultural Systems and Practices
- Aquatic Ecosystems and Biodiversity
- Indoor Air Quality and Microbial Exposure
- Food Safety and Hygiene
- Agricultural safety and regulations
- Microbial infections and disease research
- Plasma Applications and Diagnostics
- Alkaloids: synthesis and pharmacology
Queen's University Belfast
2013-2024
Queen's University
2012-2015
Aflatoxin is considered to be the most important mycotoxin in world for human food and animal feed. Current strategies reduction of mycotoxins feed includes both prevention removal. It clear that development implementation novel decontamination methods critical protection health. This review focuses on post-harvest- biological, chemical physical processes could potentially applied aflatoxin decontamination. The application technologies are reviewed detail, as well advantages, disadvantages...
Gremlin (Grem1) is a member of the DAN family secreted bone morphogenetic protein (BMP) antagonists. Bone protein-7 (BMP-7) mediates protective effects during renal fibrosis associated with diabetes and other diseases. The pathogenic mechanism Grem1 diabetic nephropathy (DN) has been suggested to be binding inhibition BMP-7. However, precise interactions between Grem1, BMP-7 BMPs have not accurately defined. In present study, we show affinity for lower than that BMP-2 BMP-4, using...
Abstract Harmful Algal Blooms (HABs) in freshwater systems and intensified aquaculture have increased the risk to human health through exposure cyanotoxins such as microcystin-LR (MC-LR). To understand uptake processing of MC-LR humans, pig was chosen an animal model. This assessed by repeated for 13 weeks eight animals dosed daily with at 0.04 µg/kg bw, six over five a dose 50 times higher 2 bw. An analytical method developed porcine serum also analyse levels free harvested tissues, Lemieux...
Raw feed materials are often contaminated with mycotoxins, and co-occurrence of mycotoxins occurs frequently. A total 250 samples i.e., rice bran maize from Cambodia, Laos, Myanmar, Thailand were analysed using state-of-the-art liquid chromatography-mass spectrometry (LC-MS/MS) for monitoring the occurrence regulated, emerging, masked mycotoxins. Seven regulated – aflatoxins, ochratoxin A, fumonisin B1, deoxynivalenol, zearalenone, HT-2, T-2 toxin detected as well some emerging such...
Contamination of animal feed with multiple mycotoxins is an ongoing and growing issue, as over 60% cereal crops worldwide have been shown to be contaminated mycotoxins. The present study was carried out assess the efficacy commercial additives sold multi-mycotoxin binding claims. Ten were obtained categorised into three groups based on their main composition. Their capacity simultaneously adsorb deoxynivalenol (DON), zearalenone (ZEN), fumonisin B1 (FB1), ochratoxin A (OTA), aflatoxin (AFB1)...
Several studies have reported a wide range of severe health effects as well clinical signs, when livestock animals are exposed to high concentration mycotoxins. However, little is known regarding mycotoxins at low levels. Thus, long-term feeding trial (between May 2017 and December 2019) was used evaluate the effect doses mycotoxin mixtures on performance broiler chickens fed naturally contaminated diet. In total, 18 successive trials were carried out during study period, with approximately...
Context: Freshwater cyanobacterial toxins, microcystins, may be a contributing factor to the development of hepatocellular cancer and colorectal cancer.Objectives: This review summarizes toxicity data, exposure routes methodologies available determine elucidate relationship liver cancer.Methods: Literature searches were conducted using Medline, PubMed Web Science.Results: There is evidence human poisonings resulting from however current methods rely on targeted approaches only suitable for...
Controversy surrounds the proposed hypothesis that exposure to β-methylamino-L-alanine (BMAA) could play a role in various neurodegenerative conditions including Alzheimer's disease (AD). Here we present results of most comprehensive scientific study on BMAA detection ever undertaken brain samples from patients pathologically confirmed have suffered AD, and those healthy volunteers. Following full validation highly accurate sensitive mass spectrometric method, no trace was detected diseased...
As human co-exposure to natural toxins through food and water is inevitable, risk assessments safeguard health are necessary. Aflatoxin B1 fumonisin B1, frequent co-contaminants of maize microcystin-LR, produced in freshwater by cyanobacteria all naturally occurring potent that threaten health. Populations the poorest regions world may suffer repeated simultaneous exposure these contaminants. Using High Content Analysis, multiple cytotoxicity endpoints were measured for individual mixtures...
Abstract With continued global population expansion, food production will have to increase with crops protected against the growing menace of pests, requiring increased use pesticides globally ensure that agricultural is optimised and remains economically viable. The aim this systematic review was perform an in-depth analysis pesticide legislation, focusing on rice, understand gaps exist in harmonisation across different countries. Tricyclazole, carbendazim, thiamethoxam acephate were...
A rapid screening assay (9 min/sample) has been developed and validated for the detection of deoxynivalenol in durum wheat, wheat products, maize-based baby foods using an SPR biosensor. Through a single laboratory validation, limits (LOD) wheat-based breakfast cereal, food were 57, 9, 6 μg/kg, respectively. Intra-assay interassay precisions calculated each matrix at maximum half-maximum European Union regulatory expressed as coefficient variation (CV). All CVs fell below 10% with exception...
A single-step lateral flow immunoassay was developed and validated to detect okadaic acid (OA) dinophysis toxins (DTXs), which cause diarrhetic shellfish poisoning. The performance characteristics of the test were investigated, in comparison reference methods (liquid chromatography tandem mass spectrometry and/or bioassay), using both spiked naturally contaminated shellfish. portable reader used generate a qualitative result, indicating absence or presence OA-group toxins, at concentrations...
In recent times surface plasmon resonance has demonstrated its applicability to the detection of a wide range contaminants in food and feed including mycotoxins cereals cereal-based products. Commercially available, laboratory-based systems have exploited high affinity polyclonal, monoclonal recombinant antibodies robust sensing surfaces provide rapid, accurate sensitive means determining these toxins. addition many custom-built, prototype devices shown great deal potential for this...