A5065527238- Single-cell and spatial transcriptomics
- Analytical chemistry methods development
- Metallic Glasses and Amorphous Alloys
- Microfluidic and Capillary Electrophoresis Applications
- Zeolite Catalysis and Synthesis
- Traditional Chinese Medicine Analysis
- Electromagnetic wave absorption materials
- Analytical Chemistry and Chromatography
- Phytochemistry and Biological Activities
- Ferroelectric and Piezoelectric Materials
- RNA modifications and cancer
- Microwave Dielectric Ceramics Synthesis
- Mesoporous Materials and Catalysis
- Catalysis and Hydrodesulfurization Studies
- Natural product bioactivities and synthesis
- Cancer-related molecular mechanisms research
- Plant-based Medicinal Research
- Atrial Fibrillation Management and Outcomes
- Tea Polyphenols and Effects
- Anomaly Detection Techniques and Applications
- Genomics and Phylogenetic Studies
- Gene expression and cancer classification
- Extracellular vesicles in disease
- Flavonoids in Medical Research
- Traditional Chinese Medicine Studies
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2024
Zhongnan University of Economics and Law
2021-2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2023
Ministry of Education of the People's Republic of China
2016-2022
Taiyuan University of Technology
2015-2022
National Medical Products Administration
2022
Tiangong University
2020
Shandong Jianzhu University
2017-2018
Jiangsu University
2015
Fuzhou University
2012-2013
This study aimed to investigate the LEF-1-mediated Wnt/β-catenin pathway for its biological functions and prognostic value in colon cancer (CC). Furthermore, potential molecular mechanism of β-sitosterol CC was investigated vitro. Clinical information gene expression profiles from patients were obtained based on Gene Expression Omnibus (GEO) The Cancer Genome Atlas (TCGA) databases. In addition, we applied R software "Limma" package differential analysis LEF-1 between para-carcinoma tissue...
MicroRNAs (miRNAs) are identified as crucial gene regulators in response to myocardial infarction (MI). However, the overall relationships between miRNAs and targets which contribute cellular phenotypes MI not fully elucidated. To make a better understanding towards functional roles of MI, useful information was mined through bioinformatic techniques.MI-related were retrieved from publications, PicTar, TargetScanS, miRanda programs used predict their targets. Gene ontology (GO) pathway...
Abstract The cell type identification is among the most important tasks in single-cell RNA-sequencing (scRNA-seq) analysis. Many silico methods have been developed and can be roughly categorized as either supervised or unsupervised. In this study, we investigated performances of 8 10 unsupervised using 14 public scRNA-seq datasets different tissues, sequencing protocols species. We impacts a number factors, including total amount cells, types, depth, batch effects, reference bias, population...
The detection of anomalous tissue regions (ATRs) within affected tissues is crucial in clinical diagnosis and pathological studies. Conventional automated ATR methods, primarily based on histology images alone, falter cases where ATRs normal have subtle visual differences. recent spatial transcriptomics (ST) technology profiles gene expressions across regions, offering a molecular perspective for detecting ATRs. However, there dearth methods that effectively harness complementary information...
To investigate the potential causal relationship between DNA methylation GrimAge acceleration (GAA) and brain tumor incidence using a two-sample Mendelian randomization (MR) approach. We leveraged publicly available genome-wide association study (GWAS) summary data for GAA (34,467 participants) (491,542 participants). Twenty-six single nucleotide polymorphisms (SNPs) served as instrumental variables GAA. Inverse variance weighted (IVW) was primary method, complemented by MR-Egger, median,...
Abstract Feature gene selection has significant impact on the performance of cell clustering in single-cell RNA sequencing (scRNA-seq) analysis. A well-rounded feature (FS) method should consider relevance, redundancy and complementarity features. Yet most existing FS methods focus relevance to types but neglect complementarity, which undermines performance. We develop a novel computational GeneClust select genes for scRNA-seq clustering. groups based their expression profiles, then selects...
Many studies have supported that long noncoding RNAs (lncRNAs) perform various functions in critical biological processes. Advanced experimental and computational technologies allow access to more information on lncRNAs. Determining the action mechanisms of these a large scale is urgently needed. We provided lncRNATargets, which web-based platform for lncRNA target prediction based nucleic acid thermodynamics. The nearest-neighbor (NN) model was used calculate binging-free energy. main...
The single molecule, real time (SMRT) sequencing technology of Pacific Biosciences enables the acquisition transcripts from end to due its ability produce extraordinarily long reads (>10 kb). This new method transcriptome has been applied several projects on humans and model organisms. However, raw data SMRT are relatively low quality, with a random error rate approximately 15 %, for which correction using next-generation (NGS) short is typically necessary. Few tools have designed that apply...
Background Hemorrhage represents the most common and serious side effect of antithrombotic agents. Many studies have compared risk bleeding between different agents, but analysis time-to-onset for hemorrhage induced by these drugs is yet sparse.
ABSTRACT A molecularly imprinted polymer (MIP) prepared with Pickering emulsion polymerization was designed by a computational approach for removal of acephate from aqueous solution. Methacrylic acid, ethylene glycol dimethacrylate, and chloroform were screened as the optimal functional monomer, crosslinker, porogen Gaussian 03 package using density theory method. The carried out in an oil‐in‐water nano‐SiO 2 particles stabilizer instead toxic surfactant. characterization results indicated...
With regard to previous tensile deformation models simulating the behavior of in-situ dendrite-reinforced metallic glass matrix composites (MGMCs) [Qiao et al., Acta Mater. 59 (2011) 4126; Sci. Rep. 3 (2013) 2816], some parameters, such as yielding strength dendrites and matrix, strain-hardening exponent dendrites, are estimated based on literatures. Here, Ti48Zr18V12Cu5Be17 MGMCs investigated in order improve model reveal mechanisms. The is obtained experimentally combining nano-indentation...
Abstract An electrochemical molecularly imprinted polymer (MIP) sensor for detecting the existence of epigallocatechin‐3‐gallate (EGCG) in tea and its products was successfully developed on basis a glassy carbon electrode modified with an electropolymerized nonconducting poly( o ‐phenylenediamine) film. The properties were characterized by cyclic voltammetry, differential pulse infrared spectroscopy. template molecules could be rapidly thoroughly removed methanol/acetic acid. linear response...
Traditional Chinese medicines largely lack adequate and scientifically rigorous evidence regarding efficacy functional mechanisms. The present study was aimed to confirm the hypoglycemic effect of Tangningtongluo (TNTL) formula, a traditional Miao medicine, in two animal models: high-fat diet streptozotocin- (STZ-) induced diabetic rats C57BL/KsJ-db/db mice. After 4 weeks, TNTL intervention STZ-induced yielded significant improvement on glucose tolerance test. Moreover, islet histopathology...
Hierarchical ZSM-5 with loose nanocrystallites was synthesized by a traditional hydrothermal procedure. Factors controlling the formation of hierarchical zeolite were investigated in detail. Despite having comparable acid properties, increased external surfaces offer ZSM-5n an excellent catalytic performance. After reaction for 414 h, catalyst still keeps 88.5% conversion isopropylbenzene, while ZSM-5μ and ZSM-5m catalysts only show 37.5% (25.8 h), 28.2% (11 h) conversions, respectively;...