A5100436078- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Gut microbiota and health
- Pediatric health and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Nutrition and Health in Aging
- Neonatal Respiratory Health Research
- Air Quality and Health Impacts
- Pleural and Pulmonary Diseases
- RNA regulation and disease
- Mast cells and histamine
- Urological Disorders and Treatments
- Eicosanoids and Hypertension Pharmacology
- Heme Oxygenase-1 and Carbon Monoxide
- Adipose Tissue and Metabolism
- Neonatal and fetal brain pathology
- Prostate Cancer Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Nosocomial Infections in ICU
- Lung Cancer Diagnosis and Treatment
- Fatty Acid Research and Health
- Acupuncture Treatment Research Studies
- Chronic Lymphocytic Leukemia Research
- Advanced Breast Cancer Therapies
Utrecht University
2021-2024
University Medical Center Groningen
2023-2024
University of Groningen
2023-2024
Sichuan University
2024
West China Hospital of Sichuan University
2024
First Affiliated Hospital of Harbin Medical University
2024
Harbin Medical University
2024
Peking University Shougang Hospital
2024
Cancer Research Institute
2023
National University College
2023
Mitochondrial damage leading to oxidant stress may play an important role in the pathogenesis of airflow obstruction and emphysema. NLPR3 inflammasome can be activated by mitochondrial ROS (mtROS) other stimuli. We examined importance mtROS NLRP3 their interactions multiple ozone-induced lung inflammation emphysema.C57/BL6 mice were exposed ozone (2.5 ppm, 3 h) or filtered air twice a week over 6 weeks. MitoTEMPO (20 mg/kg), inhibitor mtROS, VX765 (100 caspase-1 activity, administered...
Bronchial asthma is the most common chronic respiratory disease. Chronic airway inflammation, airflow restriction and hyper-responsiveness are its main manifestations. In recent decades, prevalence mortality of have been increasing all over world, which seriously threatens public health. Research suggests that air pollution associated with increased incidence asthma. PM2.5 one complex pollutants in atmospheric environment harmful to human It related However, molecular mechanism development...
Chronic obstructive pulmonary disease (COPD) is often associated with intestinal comorbidities. In this study, changes in homeostasis and immunity a cigarette smoke (CS)- lipopolysaccharide (LPS)-induced COPD model were investigated. Mice exposed to or air for 72 days, except days 42, 52, 62 on which the mice treated saline LPS via intratracheal instillation. Cigarette exposure increased airway inflammatory cell numbers, mucus production, different mediators, including C-reactive protein...
Brain-related comorbidities are frequently observed in chronic obstructive pulmonary disease (COPD) and related to increased progression mortality. To date, it is unclear which mechanisms involved the development of brain-related problems COPD. In this study, a cigarette smoke lipopolysaccharide (LPS) exposure murine model was used induce COPD-like features assess impact on brain behavior. Mice were daily exposed for 72 days, except days 42, 52, 62, mice intratracheally bacterial trigger...
Abstract Objectives To evaluate whether the urinary continence (UC) recovery after robotic-assisted radical prostatectomy (RARP) relates to membranous urethral length (MUL) and complex volume (MUV). Materials methods 120 patients who underwent RARP were enrolled according different times of UC examined using prostate magnetic resonance imaging (MRI) before surgery. The (MU) parameters measured three-Dimensional (3D) model reconstructed by holographic technology, such as total MUV (tMUV),...
Background: Adaptive immunity plays a critical role in atherosclerosis and hypertension. T helper 17 (Th17) cells, as new T-cell lineage, are involved cardiovascular diseases. Dendritic cells (DCs) the professional antigen-presenting with pivotal orchestrating adaptive immunity. Thymic stromal lymphopoietin (TSLP) can activate DCs trigger immune responses. What of TSLP hypertension has not been investigated. Methods Results: We measured expression primary rat vascular smooth muscle (VSMCs)...
Chronic obstructive pulmonary disease (COPD), often caused by smoking, is a chronic lung with systemic manifestations including metabolic comorbidities. This study investigates adaptive and pathological alterations in adipose skeletal muscle tissue following cigarette smoke exposure using vivo vitro models. Mice were exposed to or air for 72 days the pre-adipose cell line 3T3-L1 was utilized as an model. Cigarette decreased body weight, proportional loss fat mass more pronounced than lean...
Chronic obstructive pulmonary disease (COPD) patients and smokers have a higher incidence of intestinal disorders. The aim this study was to gain insight into the transcriptomic changes in lungs intestines, fecal microbial composition after cigarette smoke exposure. Mice were exposed their lung ileum tissues analyzed by RNA sequencing. top 15 differentially expressed genes investigated publicly available gene expression datasets COPD Crohn’s (CD) patients. murine microbiota determined 16S...
Context: Approximately four million people die every year from chronic obstructive pulmonary disease (COPD), with more than 80% of the cases attributed to smoking.Object: The purpose this study was examine rat strain and sex-related differences extended tobacco smoke exposure induce lung injury inflammation goal finding a suitable rodent model COPD.Methods: Male female spontaneously hypertensive (SH) male Wistar Kyoto (WKY) rats were exposed filtered air (FA) or (TS: 90 mg/m3 particulate...
Airway remodeling is strongly correlated with the progression of chronic obstructive pulmonary disease (COPD). In this study, our goal was to characterize progressive structural changes in site-specific airways, along temporal and spatial expression transforming growth factor (TGF)-β lungs male spontaneously hypertensive rats exposed tobacco smoke (TS). Our studies demonstrated that TS-induced airways dependent on airway generation exposure duration for proximal, midlevel, distal airways....
Chronic obstructive pulmonary disease (COPD) caused by cigarette smoke (CS) is featured oxidative stress and chronic inflammation. Due to the poor efficacy of standard glucocorticoid therapy, new treatments are required. Here, we investigated whether novel compound SUL-151 with mitoprotective properties can be used as a prophylactic therapeutic treatment in murine CS-induced inflammation model. (4 mg/kg), budesonide (500 μg/kg), or vehicle were administered via oropharyngeal instillation...
The role of PM2.5 in the bronchial asthma remains unclear. In this study, deficient mice TLR4-/-, TLR2-/- and MyD88 -/- were used to establish model. effects on inflammatory response lung tissue these observed. increased alveolar macrophages neutrophils, up-regulated IL-12 KC expression WT mice, but down-regulated their levels TLR2 -/-, TLR4 mice. OVA+PM2.5 stimulated neutrophil count it decreased also Eotaxin, IL-5, IL-13 MCP-3 levels, OVA specific IgE IgG1 serum group. may activate NF-κB...
Purpose: To quantitatively identify abnormal lung motion in chronic obstructive pulmonary disease (COPD) using strain analysis, and further clarify the potential differences of deformation COPD with different severity airflow limitation. Materials Methods: Totally, 53 patients at high-risk for were enrolled this study. All CT examinations performed on a 320-row MDCT scanner, measurement based dynamic-ventilation data was computational fluid dynamics analysis software (Micro Vec V3.6.2). The...
The translocation of intestinal flora has been linked to the colonization diverse and heavy lower respiratory in patients with septic ARDS, is considered a critical prognostic factor for patients.
Objectives: This study analyzed the long-term cost-effectiveness of fluticasone/umeclidinium/vilanterol triple combination (FF/UMEC/VI) vs. budesonide/formoterol double (BUD/FOR) in treatment moderate-to-severe chronic obstructive pulmonary disease (COPD) and provides evidence for COPD decisions. Methods: From perspective healthcare system, a Markov model was established that consists four states-stable period, non-severely deteriorating severely death-according to real-world progression....
While inhaled corticosteroids (ICS) may increase pneumonia risk in patients with chronic obstructive pulmonary disease (COPD), the impact of ICS on outcomes is debated. We examined whether use associated adverse among COPD community-acquired (CAP).Population-based cohort study all an incident hospitalization for CAP between 1997 and 2013 Northern Denmark. Information medications, severity, comorbidities, complications, death was obtained from medical databases. Adjusted ratios (aRRs)...
Exploring candidate markers to predict the clinical outcomes of pulmonary infection in stroke patients have a high unmet need. This study aimed develop machine learning (ML)-based predictive models for infection.Between January 2008 and April 2021, retrospective analysis 1397 who had CT angiography from skull diaphragm (including chest) within 24 hours symptom onset. A total 21 variables were included, prediction model was established by multiple ML-based algorithms. Risk factors determined...