A5090398853- Asthma and respiratory diseases
- Advanced Chemical Sensor Technologies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Musicology and Musical Analysis
- Respiratory Support and Mechanisms
- Inhalation and Respiratory Drug Delivery
- Air Quality and Health Impacts
- Analytical Chemistry and Chromatography
- Gas Sensing Nanomaterials and Sensors
- Neonatal Respiratory Health Research
- Diverse Musicological Studies
- Nitric Oxide and Endothelin Effects
- Pediatric health and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Mass Spectrometry Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Climate Change and Health Impacts
- Eosinophilic Esophagitis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neuroscience of respiration and sleep
- Biosensors and Analytical Detection
- Occupational exposure and asthma
- Analytical Chemistry and Sensors
- Air Quality Monitoring and Forecasting
University of California, Davis
2016-2025
VA Northern California Health Care System
2017-2025
UC Davis Health System
2023-2025
University of California Davis Medical Center
2012-2023
Veterans Health Administration
2021
University of California System
2011-2020
University of Oxford
2019
California State University, Sacramento
2019
Pulmonary and Critical Care Associates
2004-2017
SleepMed
2004-2017
Background: The fractional exhaled nitric oxide (FENO) test is a point-of-care that used in the assessment of asthma. Objective: To provide evidence-based clinical guidance on whether FENO testing indicated to optimize asthma treatment patients with whom being considered. Methods: An international, multidisciplinary panel experts was convened form consensus document regarding single question relevant use FENO. selected from three potential questions based greatest perceived impact practice...
Abstract The mevalonate (MEV) cascade is responsible for cholesterol biosynthesis and the formation of intermediate metabolites geranylgeranylpyrophosphate (GGPP) farnesylpyrophosphate (FPP) used in prenylation proteins. Here we show that MEV inhibitor simvastatin induced significant cell death a wide range human tumor lines, including glioblastoma, astrocytoma, neuroblastoma, lung adenocarcinoma, breast cancer. Simvastatin apoptotic via intrinsic pathway. In all cancer types tested,...
Idiopathic pulmonary fibrosis (IPF) is a lethal fibrotic lung disease in adults with limited treatment options. Autophagy and the unfolded protein response (UPR), fundamental processes induced by cell stress, are dysregulated fibroblasts epithelial cells from humans IPF. Human primary cultured parenchymal airway non-IPF IPF donors were stimulated transforming growth factor-β1 (TGF-β1) or without inhibitors of autophagy UPR (IRE1 inhibitor). Using immunoblotting, we monitored temporal changes...
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
<b>Background:</b> Subepithelial collagen and extracellular matrix protein deposition are important pathophysiological components of airway remodelling in chronic asthma. Animal models based on the local reaction to antigens show structural alterations submucosal region provide information regarding disease pathophysiology. We describe a murine model peribronchial fibrosis using intratracheally instilled transforming growth factor (TGF)-β<sub>1</sub> BALB/C mice that facilitates mechanistic...
Rationale: Statin use has been linked to improved lung health in asthma and chronic obstructive pulmonary disease. We hypothesize that statins inhibit allergic airway inflammation reduce hyperreactivity via a mevalonate-dependent mechanism.Objectives: To determine whether simvastatin attenuates improves physiology by mevalonate pathway inhibition.Methods: BALB/c mice were sensitized ovalbumin over 4 weeks exposed 1% aerosol 2 weeks. Simvastatin (40 mg/kg) or plus (20 was injected...
Abstract The Th1/Th2 paradigm has become an important issue in the pathogenesis of asthma, characterized by normal Th1 and elevated Th2 cytokine expression. Vitamin A deficiency (VAD) can produce a bias, whereas high-level dietary vitamin promote bias. We used OVA exposure mouse model to determine contributions A-deficient, control (4IU/g), (250-IU/g) diets development allergic airway inflammation hyperresponsiveness. VAD reduced serum IgE IgG1 responses, pulmonary eosinophilia, levels IL-4...
Combination of two physical phenomena, capillary pressure gradient and wettability gradient, allows a simple two-step fabrication process that yields reliable hydrophobic self-cleaning condenser surface. The surface is fabricated with specific microscopic topography further treatment chemically inert low-surface-energy material. This does not require growth nanofeatures (nanotubes) or hydrophilic-hydrophobic patterning the Trapezoidal geometry microfeatures facilitates droplet transfer from...
Obesity and accompanying metabolic disease is negatively correlated with lung health yet the exact mechanisms by which obesity affects are not well characterized. Since associated diseases as chronic bronchitis asthma, we designed a series of experiments to measure changes in metabolism mice fed obesogenic diets. Mice were either control or high fat/sugar diet (45%kcal fat/17%kcal sucrose), very fat (60%kcal fat/7% sucrose) for 150 days. We performed untargeted metabolomics GC-TOFMS...
Mobile health monitoring via non-invasive wearable sensors is poised to advance telehealth for older adults and other vulnerable populations. Extreme heat environmental conditions raise serious challenges that warrant of real-time physiological data as people go about their normal activities. systems could be beneficial many communities, including elite athletes, military special forces, at-home geriatric monitoring. While some commercial monitors exist, they are bulky, require...
Autophagy, apoptosis, and the unfolded protein response (UPR) are fundamental biological processes essential for manifold cellular functions in health disease. Idiopathic pulmonary fibrosis (IPF) is a progressive lethal disorder associated with aging that has limited therapies, reflecting our incomplete understanding. We conducted an observational study linking molecular markers of cell stress pathways (UPR: BiP, XBP1; apoptosis: cleaved caspase-3; autophagy: LC3β) lung tissues from IPF...
We hypothesised that severe asthmatics taking a statin drug, in addition to inhaled corticosteroids/long-acting β-agonist inhaler therapy, would have better asthma symptom control and improved lung function compared their controls.A retrospective, cross-sectional study of 165 patients with seen from 2001-2008. Hierarchical linear logistic regression models were used for modelling fitting.University California, Davis Medical Center (Sacramento, USA). Academic, single-centre, subspecialty...
It has been shown that morphologic and biochemical presynaptic markers of dopaminergic terminals are preserved in a unilateral experimental model neonatal hypoxic-ischemic injury to the striatum. As substantia nigra is spared direct this model, we anticipated number tyrosine hydroxylase-positive neurons projecting striatum would also be normal. We have found, however, following striatal ipsilateral decreased, as mean area pars compacta. The decrease correlated with size (r = 0.7, P 0.01)....
Perinatal exposure to maternal smoke is associated with adverse pulmonary effects, including reduced lung function and increased incidence of asthma. However, the mechanisms underlying these effects are unknown, there no effective preventive and/or therapeutic intervention. Recently, we suggested that downregulation homeostatic mesenchymal peroxisome proliferator-activated receptor-γ (PPARγ) signaling following in utero nicotine might contribute chronic diseases such as We used an vivo rat...
Nanocarriers can deliver a wide variety of drugs, target them to sites interest, and protect from degradation inactivation by the body. They have capacity improve drug action decrease undesirable systemic effects. We previously developed well-defined non-toxic PEG-dendritic block telodendrimer for successful delivery chemotherapeutics agents and, in these studies, we apply this technology therapeutic development asthma. In proof-of-concept experiments, hypothesized that dexamethasone...
Control of airway inflammation is critical in asthma treatment. Soluble epoxide hydrolase (sEH) has recently been demonstrated as a novel therapeutic target for treating inflammation, including lung inflammation. We hypothesized that pharmacological inhibition sEH can modulate the inflammatory response murine ovalbumin (OVA) model asthma. BALB/c mice were sensitized and exposed to OVA over 6 weeks. A inhibitor (sEHI) was administered 2 Respiratory system compliance, resistance, forced...
We have developed a simple-to-manufacture microfabricated gas preconcentrator for MEMS-based chemical sensing applications. Cavities and microfluidic channels were created using wet etch process with hydrofluoric acid, portions of which can be performed outside cleanroom, instead the more common deep reactive ion process. The integrated heater resistance temperature detectors (RTDs) photolithography-free technique enabled by laser etching. With only 28 V DC (0.1 A), maximum heating rate 17.6...