A5055291097- Nerve injury and regeneration
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Neurogenesis and neuroplasticity mechanisms
- Nuclear Receptors and Signaling
- Neuroscience and Neural Engineering
- Botulinum Toxin and Related Neurological Disorders
- Muscle activation and electromyography studies
- Neural dynamics and brain function
- Neonatal and fetal brain pathology
- Genetic Neurodegenerative Diseases
- American Constitutional Law and Politics
- Mitochondrial Function and Pathology
- Cell death mechanisms and regulation
- Ion channel regulation and function
- Autophagy in Disease and Therapy
- Spinal Cord Injury Research
- Hereditary Neurological Disorders
- Vestibular and auditory disorders
- Transcranial Magnetic Stimulation Studies
- Receptor Mechanisms and Signaling
- Endoplasmic Reticulum Stress and Disease
- Pain Mechanisms and Treatments
- Neurogenetic and Muscular Disorders Research
University of Florida
2025
HonorHealth
2022-2023
National Institutes of Health
2000-2022
National Institute of Neurological Disorders and Stroke
1999-2022
University of Pennsylvania
2020
Columbia University
2009-2018
Columbia University Irving Medical Center
2005-2018
Columbia College
1986-2016
Royal College of Physicians
1985-2016
Montefiore Health System
2015
For quantitative assessment of the primary torsion dystonias, a rating scale is proposed that has two sections—a Movement Scale, based on examination, and Disability patient9s statements about seven activities daily living. We assessed validity Scale by comparing scores with ranking patients according to dystonia severity ratings Scale. In addition, we inter-and intra-rater reliability independent scorings four examiners same performed at different times. found was valid reliable indicator dystonia.
Despite tremendous growth in recent years our knowledge of the molecular basis Parkinson disease (PD) and pathways cell injury death, we remain without therapies that forestall progression. Although there are many possible explanations for this lack success, one is experimental therapeutics to date have not adequately focused on an important component process, axon degeneration. It remains unknown what neuronal compartment, either soma or axon, involved at onset, although some proposed it...
The correlation among a variety of physiological properties and the histochemical characteristics muscle fibers belonging to single motor units in mixed mammalian is directly demonstrated. population making up cat gastrocnemius was classified into three nonoverlapping groups on basis combination parameters. each type exhibited distinctive profile, such that basic "fiber types" exactly matched physiologically defined groups. Within individual unit, were histochemically uniform.
Mechanisms responsible for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopamine (DA) neuronal death remain unknown and in mice it is even unclear whether does occur. In vitro studies suggest that 1-methyl-4-phenylpyridinium ion (MPP+), the active metabolite of MPTP, kills neurons by apoptosis. Herein, we investigated MPTP induces DA vivo mechanism C57/bl Mice received different doses administered four intraperitoneal injections every 2 hours were sacrificed at time points...
It is not widely recognized that antipsychotic drugs can cause late-onset and persistent dystonia. This dystonia, which we call tardive to be distinguished from acute dystonic reactions, are transient, classic dyskinesia, a choreic disorder predominantly affects the oral region. We present 42 patients with The age of onset dystonia was 13 60 years. Symptoms began after 3 days 11 years therapy. Younger tended have more generalized In few patients, spontaneous remission occurred, but persisted...
Parkinson's disease (PD) is most commonly a sporadic illness, and characterized by degeneration of substantia nigra dopamine (DA) neurons abnormal cytoplasmic aggregates α-synuclein. Rarely, PD may be caused missense mutations in MPTP, neurotoxin that inhibits mitochondrial complex I, prototype for an environmental cause because it produces pattern DA neurodegeneration closely resembles the neuropathology PD. Here we show α-synuclein null mice display striking resistance to MPTP-induced...
A method to characterize dynamical interdependence among nonlinear systems is derived based on mutual prediction. Systems with correlation will show prediction when standard analysis linear cross might fail. Mutual also provides information the directionality of coupling between systems. Furthermore, existence bidirectional in unidirectionally coupled implies generalized synchrony. Numerical examples studied include three classes systems: identical parameters, nonidentical and stochastic...
Dopaminergic (DA) neurons of substantia nigra in the midbrain control voluntary movement, and their degeneration is cause Parkinson's disease. The complete set genes required to specifically determine development DA subgroups not known yet. We report here that mice lacking bicoid -related homeoprotein Pitx3 fail develop nigra. Other mesencephalic ventral tegmental area retrorubral field are unaltered dopamine expression histological organization. These data suggest Pitx3-dependent gene for...
1. Muscle fibres belonging to single motor units of identified type were studied in frozen sections cat medial and lateral gastrocnemius muscles. Reconstruction the distribution individual showed that territories all three physiological types present quite extensive. Within its territory, unit distributed more or less uniformly without localized collections. The density suggests that, gastrocnemius, a given region muscle may be shared by as many fifty different units.2. Direct determination...
Abstract There is increasing evidence that neuron death in neurodegenerative diseases, such as Parkinson's disease, due to the activation of programmed cell death. However, upstream mediators remain largely unknown. One approach identification perform gene expression analysis disease models. Such analyses, performed tissue culture models induced by neurotoxins, have identified up‐regulation CHOP/GADD153, a transcription factor implicated apoptosis endoplasmic reticulum stress or oxidative...
The 6-hydroxydopamine (6-OHDA) model of nigral injury in rats has been use as a standard animal parkinsonism for many years. While earlier studies established the time course loss catecholamine histofluorescence or tyrosine hydroxylase immunostaining cell bodies and terminals, these alterations phenotypic expression do not define morphologic degeneration. We have therefore used silver impregnation method to characterize morphology degeneration neurons nigrostriatal system. Abundant neuronal...
We studied trihexyphenidyl in the treatment of torsion dystonia a prospective, double-blind crossover protocol. Thirty-one patients completed Twenty-two (71%) had clinically significant response. After mean follow-up 2.4 years, 68% continued to take trihexyphenidyl, and 42% show considerable or dramatic benefit. The 30-mg dose used was generally well tolerated. High-dosage therapy is effective management dystonia.