A5007798397- Asthma and respiratory diseases
- Pancreatic function and diabetes
- Neuroinflammation and Neurodegeneration Mechanisms
- T-cell and B-cell Immunology
- Psoriasis: Treatment and Pathogenesis
- Cardiovascular Health and Risk Factors
- Respiratory and Cough-Related Research
- Cardiac Fibrosis and Remodeling
- Immune cells in cancer
- Cardiac electrophysiology and arrhythmias
- Neuropeptides and Animal Physiology
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Cardiovascular and exercise physiology
- Cannabis and Cannabinoid Research
- GDF15 and Related Biomarkers
- Renin-Angiotensin System Studies
- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- Cardiac Arrest and Resuscitation
- Cardiovascular Function and Risk Factors
- Cardiac Ischemia and Reperfusion
- Family and Patient Care in Intensive Care Units
- Regulation of Appetite and Obesity
- Alcohol Consumption and Health Effects
Massachusetts Eye and Ear Infirmary
2024
Smith-Kettlewell Eye Research Institute
2024
Harvard University
2024
National Institute on Alcohol Abuse and Alcoholism
2010-2023
National Institutes of Health
2004-2023
Hubei Zhongshan Hospital
2021
Wuhan University
2021
Shenzhen University
2020
St. Michael's Hospital
2014
University Health Network
2014
Resistant ventricular fibrillation, refibrillation. and diminished myocardial contractility are important factors leading to poor survival after cardiac arrest. We hypothesized that dantrolene improves fibrillation (VF) by rectifying the calcium dysregulation caused VF.VF was induced in 26 Yorkshire pigs for 4 minutes. Cardiopulmonary resuscitation then commenced 3 minutes, or isotonic saline infused at onset of cardiopulmonary resuscitation. Animals were defibrillated observed 30 To study...
The amygdala is part of the brain reward circuitry that plays a role in cocaine-seeking and abstinence animals cocaine craving relapse humans. Cocaine-seeking elicited by cocaine-associated cues, basolateral (BLA) CeA are essential forming communicating drug-related associations thought to be critical long-lasting risk associated with drug addiction. Here we simulated cue stimulus high-frequency stimulation (HFS) BLA-CeA pathway examine mechanisms may contribute associations. We found...
Perinatal exposure to maternal smoke is associated with adverse pulmonary effects, including reduced lung function and increased incidence of asthma. However, the mechanisms underlying these effects are unknown, there no effective preventive and/or therapeutic intervention. Recently, we suggested that downregulation homeostatic mesenchymal peroxisome proliferator-activated receptor-γ (PPARγ) signaling following in utero nicotine might contribute chronic diseases such as We used an vivo rat...
BACKGROUND: EMCN (endomucin), an endothelial-specific glycocalyx component, was found to be highly expressed by the endothelium of renal glomerulus. We reported anti-inflammatory role and its involvement in regulation VEGF (vascular endothelial growth factor) activity through modulating VEGFR2 (VEGF receptor 2) endocytosis. The goal this study is investigate phenotypic functional effects deficiency using first global knockout mouse model. METHODS: Global mice were generated crossing...
Molecular interactions between anorexigenic leptin and orexigenic endocannabinoids, although of great metabolic significance, are not well understood. We report here that hypothalamic STAT3 signaling in mice, initiated by physiological elevations leptin, is diminished agonists the cannabinoid receptor 1 (CB1R). Measurement activation semi-automated confocal microscopy cultured neurons revealed this CB1R-mediated inhibition requires both T cell protein tyrosine phosphatase (TC-PTP)...
ABSTRACT The ocular surface is a mucosal barrier tissue colonized by commensal microbes, which tune local immunity eliciting IL-17 from conjunctival γδ T cells to prevent pathogenic infection. Corynebacterium mastitidis ( C. mast ) elicits protective responses Vγ4 through combination of TCR ligation and IL-1 signaling. Here, we identify Vγ6 as major -responsive subset in the conjunctiva uncover its unique activation requirements. We demonstrate that require not only extrinsic (via dendritic...
In order to comprehensively evaluate the human body's functions of breathing, heart function and circulation metabolism under controlled conditions diagnose respiratory cardiac functions, a cardiopulmonary exercise test (CPET) system was developed. The is divided into two parts:hardware software. hardware part includes measurement six life information monitoring signals such as 12-lead ECG, mechanics, blood pressure, oxygen, carbon dioxide oxygen. software realizes waveform display, storage...