A5055272459- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Tuberculosis Research and Epidemiology
- Epigenetics and DNA Methylation
- Paraoxonase enzyme and polymorphisms
- Circular RNAs in diseases
- Liver Disease Diagnosis and Treatment
- RNA Research and Splicing
- Vitamin C and Antioxidants Research
- Pneumonia and Respiratory Infections
- Cancer-related gene regulation
- Cell death mechanisms and regulation
- Endoplasmic Reticulum Stress and Disease
- Protease and Inhibitor Mechanisms
- Autophagy in Disease and Therapy
- Cleft Lip and Palate Research
- Cancer-related Molecular Pathways
- Acute Lymphoblastic Leukemia research
- Hepatitis B Virus Studies
- Glutathione Transferases and Polymorphisms
- DNA Repair Mechanisms
- Immune Cell Function and Interaction
- Folate and B Vitamins Research
- Hepatitis C virus research
Isfahan University of Medical Sciences
2009-2025
Hormozgan University of Medical Sciences
2025
Zahedan University of Medical Sciences
2015-2024
University of California, Irvine
2024
Hamedan University of Medical Sciences
2024
Golestan University
2016-2023
Golestan University of Medical Sciences
2016-2023
Shahid Beheshti University
2018-2023
Kerman University of Medical Sciences
2021
Regional Medical Center
2021
Abstract The complex formed by two members of the S100 calcium-binding protein family, S100A8/A9, exerts apoptosis-inducing activity against various cells, especially tumor cells. Here, we present evidence that S100A8/A9 also has cell growth-promoting at low concentrations. Receptor advanced glycation end product (RAGE) gene silencing and cotreatment with a RAGE-specific blocking antibody revealed this was mediated via RAGE ligation. To investigate signaling pathways, MAPK phosphorylation...
Abstract The mevalonate (MEV) cascade is responsible for cholesterol biosynthesis and the formation of intermediate metabolites geranylgeranylpyrophosphate (GGPP) farnesylpyrophosphate (FPP) used in prenylation proteins. Here we show that MEV inhibitor simvastatin induced significant cell death a wide range human tumor lines, including glioblastoma, astrocytoma, neuroblastoma, lung adenocarcinoma, breast cancer. Simvastatin apoptotic via intrinsic pathway. In all cancer types tested,...
The protein complex S100A8/A9, abundant in the cytosol of neutrophils, is secreted from cells upon cellular activation and induces apoptosis tumor cell lines normal fibroblasts a zinc-reversible manner. In present study, we evidence that S100A8/A9 also exerts its apoptotic effect by zinc-independent mechanism. Treatment colon carcinoma with different concentrations human or metal ion chelator diethylenetriaminepentacetic acid (DTPA) resulted significant increase death. Annexin...
Decreased paraoxonase-1 (PON1) activity has been associated with rheumatoid arthritis.There are two polymorphisms in serum PON1; one differs the amino acid at position 192 (Q192R) and other 55 (L55M).We looked for a possible association between Q192R polymorphism arthritis.The 88 arthritis patients 78 healthy subjects was determined using tetra amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) PCRrestriction fragment length (RFLP) methods.We found ©FUNPEC-RP...
Single nucleotide polymorphisms in pre‑microRNA (miRNA) may alter miRNA expression levels or processing and contribute to susceptibility a wide range of diseases. The present study aimed evaluate the possible association between rs2910164 rs3746444 pre-miRNA (hsa-mir-146a hsa-mir-499) rheumatoid arthritis (RA) an Iranian population. This case-control was performed on 104 patients with RA 110 healthy individuals. Tetra amplification refractory mutation system-polymerase chain reaction used...
Fas/Fas ligand (FasL) system is one of the key apoptotic signaling entities in extrinsic pathway. De-regulation this pathway, i.e. by mutations may prevent immune from removal newly-formed tumor cells, and thus lead to formation. The present study investigated association between -1377 G/A (rs2234767) -670 A/G (rs1800682) polymorphisms Fas as well single nucleotide INV2nt -124 (rs5030772) -844 C/T (rs763110) FasL a sample Iranian patients with breast cancer. This case-control was done on 134...
Genetic and environmental factors are important for the development of nonalcoholic fatty liver disease (NAFLD). Adiponectin is a white brown adipose tissue hormone, have been found to play essential roles in regulation energy homoeostasis. Recent reports identified possible role adiponectin NAFLD via PPARγ pathway.The present study was designed find out impact rs1501299 (276G/T) rs266729 (-11377C/G) gene polymorphisms NAFLD.Eighty-three patients with diagnosis NAFLD, 93 healthy subjects...
A and Alizadeh J analyzed the fluorescence immunohistochemistry results, participated in preparing apoptosis autophagy parts of manuscript, respectively; Wiechec E tissue array drafted part manuscript; Alavian SM diagnosed got liver biopsy HBV patients; Hashemi M contributed PCR or samples for HCV virus titer, results; Geramizadeh B pathology diagnosis, scoring, graded biopsies; Samali unfolded protein response, proof final versions Bagheri Lankarani K Peymani P prepared sample, biochemical...
A number of case-control studies regarding the association polymorphisms in programmed cell death 1 (PD-1) and ligand (PD-L1) genes with risk cancer have yielded inconsistent findings. Therefore, we conducted a comprehensive, updated meta-analysis study to identify impact PD-1 PD-L1 on overall susceptibility. The findings revealed that rs2227981 rs11568821 significantly decreased (Odds Ratio (OR) = 0.82, 95% CI 0.68-0.99, p 0.04, TT vs. CT+CC; OR 0.79, 0.67-0.94, 0.006, AG GG, 0.70-0.96,...
There is an increasing body of evidence which highlights the critical functions long non-coding RNAs in carcinogenicity mechanism a variety cancers. It has been reported that HOX transcript antisense intergenic RNA, member RNA family, increases breast cancer risk. To date, no data regarding association between polymorphisms and risk development Iran. Here, we examine possible gene sample southeast Iranian female population. The rs920778, rs12826786, rs4759314, 1899663 were genotyped 220...
Growing evidence showed that microRNAs (miRs) are involved in normal hematopoiesis and the pathogenesis of several hematological malignancies. Genetic variations or mutations occurring miR gene region may affect property miRs through altering expression and/or maturation. The aim present study was to evaluate possible relationship between two polymorphisms, hsa-miR-146a (rs2910164 G>C) hsa-miR-499 (rs3746444 T>C), susceptibility childhood acute lymphoblastic leukemia (ALL) a sample Iranian...
Aim: Our study aimed to evaluate the possible association between four miRNA polymorphisms, hsa-miR-146a (rs2910164 G>C), hsa-miR-499 (rs3746444 T>C) and hsa-miRNA-196a2 (rs11614913 C>T rs185070757 T>G), susceptibility breast cancer in an Iranian population. Materials & methods: In this case–control we enrolled 236 patients with 203 healthy individuals. Tetra primer amplification refractory mutation system PCR was applied for genotyping SNPs. Results: indicated that hsa-mir-499 rs3746444 CC...
The mu-opioid receptor, encoded by receptor gene (OPRM1), has an important role in the development of addiction to opioids. Its aberrant reduction on cell membrane is responsible, at least part, for tolerance and physical dependence.The present study was designed identify relationship between opium consumption epigenetic mechanisms involved addiction.Genomic DNA extracted from peripheral blood 66 men with use disorder 57 healthy as a control group. Genomic DNAs were treated sodium bisulfite...
MicroRNAs (miRNAs) play an important role in regulating gene expression at the post-transcriptional level and are involved numerous physiological processes. Accumulating evidence suggests that single-nucleotide polymorphisms (SNPs) human miRNA genes may affect biogenesis pathway influence susceptibility to several diseases such as cancer. The present study aimed evaluate impact of miR-499 rs3746444, miR-196a2 rs11614913, miR-149 rs2292832, miR-146a rs2910164 on prostate cancer (PCa) risk a...