A5100336147- Hemoglobinopathies and Related Disorders
- Anesthesia and Neurotoxicity Research
- Iron Metabolism and Disorders
- Autism Spectrum Disorder Research
- Anesthesia and Sedative Agents
- Erythrocyte Function and Pathophysiology
- Intensive Care Unit Cognitive Disorders
- Nicotinic Acetylcholine Receptors Study
- Blood groups and transfusion
- Epigenetics and DNA Methylation
- Neuroendocrine regulation and behavior
- Prenatal Screening and Diagnostics
- Birth, Development, and Health
- Mosquito-borne diseases and control
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Nitric Oxide and Endothelin Effects
- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- Neurogenesis and neuroplasticity mechanisms
- Prenatal Substance Exposure Effects
- Connective tissue disorders research
- Heavy Metal Exposure and Toxicity
- Pregnancy and preeclampsia studies
- Animal testing and alternatives
Children's National
2012-2025
George Washington University
2014-2023
University of Illinois Urbana-Champaign
2023
Marymount University
2023
Pearson (United States)
2023
Case Western Reserve University
2012-2023
Human Factors (Norway)
2023
303 Hospital of People's Liberation Army
2010-2023
University of Hong Kong
2023
Jefferson Hospital for Neuroscience
2021
Lengthy use of general anesthetics (GAs) causes neurobehavioral deficits in the developing brain, which has raised significant clinical concerns such that United States Food and Drug Administration (FDA) is warning on GAs children younger than 3 years. However, molecular cellular mechanisms for GAs-induced neurotoxicity remain largely unknown. Here, we report sevoflurane (Sevo), a commonly used GA pediatrics, caused compromised astrocyte morphogenesis spatiotemporally correlated to synaptic...
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The pain phenotype in sickle cell disease (SCD) patients is highly variable. A small percentage of SCD experience many vaso-occlusive crises/year, 5% account for over 30% episodes, while 39% report few episodes severe pain. Clearly, a better understanding the pathobiology needed to improve its therapy. Humanized mice recapitulate several phenotypes and provide model study Researchers have shown that one strain humanized mice, BERK strain, has abnormal phenotype. However, nociception another...
This study focused on the efficacy and safety of thalidomide for patients with β-thalassemia in a multicenter trial.Patients non-transfusion-dependent thalassemia (NTDT) or transfusion-dependent (TDT), who were unable to pursue conventional therapy transfusion chelation, recruited over 3 years three centers southern China. We evaluated short-term (three months) long-term follow-up (12 24 months). Response was defined as follows: Main Responder (MaR) showing an increase hemoglobin (Hb) level...
Zika, a mosquito-borne flavivirus, has been found in 87 countries and territories. Global outbreaks peaked 2016. Prenatal infection of Zika virus was to be associated with microcephaly, arthrogryposis, intracranial calcifications, fetal growth restriction, demise. The most severely affected children were diagnosed congenital syndrome, which impacts thousands worldwide. With no approved treatment or preventative measures for future viral have the potential cause epidemic levels prenatal brain...
<title>Abstract</title> Zika, a mosquito-borne flavivirus, has been found in 87 countries and territories. Global outbreaks peaked 2016. Prenatal infection of Zika virus was to be associated with microcephaly, arthrogryposis, intracranial calcifications, fetal growth restriction, demise. The most severely affected children were diagnosed congenital syndrome, which impacts thousands worldwide. With no approved treatment or preventative measures for future viral have the potential cause...
The clinical characteristics of 357 patients with hemoglobin H (HbH) disease from the Guangxi province Southern China were studied. One hundred and ninety-one (53.3%) diagnosed HbH-Constant Spring, 19 HbH Westmead. Ten shown to have coinherited Spring/QS a β-thalassemia mutation. Coinheritance gene does not alleviate anemia (8.2 ± 2.3 vs. 7.6 1.7 g/dl, p = 0.276), or influence age at diagnosis (20.2 19.6 12.9 11.0 years, 0.276). Ferritin levels significantly higher in group nondeletional...
In humans, mutations in the transcription factor encoding gene,
Transcription factor c-Jun affects neuronal cell death and survival in mammalian brain. As general anesthetics, such as ketamine propofol, are thought to provide some degree of neuroprotection, this study was intended test whether the protection injured PC12 cells by propofol is related inhibition phospho-c-Jun. Using from rat pheochromocytoma differentiated with nerve growth factor, we found that 24 hours exposure glutamate (1 100 mM) induced concentration-dependent determined an ability...
Infantile neuronal ceroid lipofuscinosis (INCL) is a fatal neurodegenerative disorder caused by deficiency of palmitoyl-protein thioesterase-1 (PPT1). We have previously shown that children with INCL increased risk hypothermia during anesthesia and PPT1-deficiency in mice associated disruption adaptive energy metabolism, downregulation peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), mitochondrial dysfunction. Here we hypothesized Ppt1-knockout mice, well-studied model...
Pulmonary hypertension (PHT) is a common complication for patients with β thalassemia intermediate (TI), especially splenectomized patients. However, the frequency and risk factors of PHT in hemoglobin H (HbH) disease unknown. The purpose this study was to identify prevalence manifested as tricuspid regurgitant jet velocity (TRV) ≥2.5 m/s HbH its correlation splenectomy. One hundred ninety-eight who visited 303rd Hospital People's Liberation Army (Nanning, China) were investigated. Thirteen...
Splenectomy is reported to increase the haemoglobin level in patients with H Constant Spring (HbH CS) disease; however, its impact on iron burden and underlying mechanism remains unclear.From March through May 2013, a total of 50 adults HbH CS disease (25 cases splenectomised 25 non-splenectomised) were enrolled. The patients' general conditions, history blood transfusion chelator treatment investigated. Levels haemoglobin, nucleated red cell counts, serum ferritin measured. percentage...