A5078249002- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Endoplasmic Reticulum Stress and Disease
- Genomic variations and chromosomal abnormalities
- Cancer Genomics and Diagnostics
- Cell death mechanisms and regulation
- Cancer-related Molecular Pathways
- Head and Neck Cancer Studies
- RNA modifications and cancer
- Tissue Engineering and Regenerative Medicine
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Phagocytosis and Immune Regulation
- Advanced Biosensing Techniques and Applications
- Nanoplatforms for cancer theranostics
- Organ Donation and Transplantation
- Hedgehog Signaling Pathway Studies
- DNA Repair Mechanisms
- Cancer Mechanisms and Therapy
- Animal Virus Infections Studies
- PI3K/AKT/mTOR signaling in cancer
- Nanoparticle-Based Drug Delivery
Linköping University
2016-2025
Katowice School of Technology
2024
Region Östergötland
2021-2023
University of Toronto
2015
Hospital for Sick Children
2015
SickKids Foundation
2015
Regenerative Medicine Institute
2014
Aarhus University
2006-2012
Aarhus University Hospital
2010-2012
Otto-von-Guericke University Magdeburg
2011
Head and Neck Squamous Cell Carcinoma (HNSCC) tumors are often resistant to therapies. Therefore searching for predictive markers new targets treatment in clinically relevant vitro tumor models is essential. Five HNSCC-derived cell lines were used assess the effect of 3D culturing compared 2D monolayers terms proliferation, response anti-cancer therapy as well expression EMT CSC genes. The viability proliferation capacity HNSCC cells induction apoptosis spheroids after was assessed by MTT...
Here, we show that CDK2, an S-phase cyclin-dependent kinase, is a novel target for Akt during cell cycle progression and apoptosis. phosphorylates CDK2 at threonine 39 residue both in vitro vivo. Although phosphorylation mediated by enhances cyclin-A binding, it dispensable its basal binding the kinase activity. In addition, first time, report transient nucleo-cytoplasmic shuttling of specific stages cycle, particular late S G2 phases. The re-localized to nucleus causes temporary cytoplasmic...
The molecular mechanism of Salinomycin's toxicity is not fully understood. Various studies reported that Ca2 +, cytochrome c, and caspase activation play a role in Salinomycin-induced cytotoxicity. Furthermore, Salinomycin may target Wnt/β-catenin signaling pathway to promote differentiation thus elimination cancer stem cells. In this study, we show massive autophagic response (substantially stronger than commonly used inducer Rapamycin) prostrate-, breast cells, lesser degree human normal...
Abstract The mevalonate (MEV) cascade is responsible for cholesterol biosynthesis and the formation of intermediate metabolites geranylgeranylpyrophosphate (GGPP) farnesylpyrophosphate (FPP) used in prenylation proteins. Here we show that MEV inhibitor simvastatin induced significant cell death a wide range human tumor lines, including glioblastoma, astrocytoma, neuroblastoma, lung adenocarcinoma, breast cancer. Simvastatin apoptotic via intrinsic pathway. In all cancer types tested,...
Liver cancer is one of the most common cancers in world and has no effective cure, especially later stages. The development a tangible protocol for early diagnosis this disease remains major challenge. In present manuscript, an aptamer-based, label-free electrochemical biosensor sensitive detection HepG2, hepatocellular carcinoma cell line, described. target cells are captured sandwich architecture using TLS11a aptamer covalently attached to gold surface secondary aptamer. application as...
A and Alizadeh J analyzed the fluorescence immunohistochemistry results, participated in preparing apoptosis autophagy parts of manuscript, respectively; Wiechec E tissue array drafted part manuscript; Alavian SM diagnosed got liver biopsy HBV patients; Hashemi M contributed PCR or samples for HCV virus titer, results; Geramizadeh B pathology diagnosis, scoring, graded biopsies; Samali unfolded protein response, proof final versions Bagheri Lankarani K Peymani P prepared sample, biochemical...
A number of case-control studies regarding the association polymorphisms in programmed cell death 1 (PD-1) and ligand (PD-L1) genes with risk cancer have yielded inconsistent findings. Therefore, we conducted a comprehensive, updated meta-analysis study to identify impact PD-1 PD-L1 on overall susceptibility. The findings revealed that rs2227981 rs11568821 significantly decreased (Odds Ratio (OR) = 0.82, 95% CI 0.68-0.99, p 0.04, TT vs. CT+CC; OR 0.79, 0.67-0.94, 0.006, AG GG, 0.70-0.96,...
The most aggressive primary malignant brain tumor in adults is glioblastoma (GBM), which has poor overall survival (OS). There a high relapse rate among patients with GBM despite maximally safe surgery, radiation therapy, temozolomide (TMZ), and treatment. Hence, there an urgent unmet clinical need for new approaches to managing GBM. current study identified modules (MYC, EGFR, PIK3CA, SUZ12, SPRK2) involved disease through the NeDRex plugin. Furthermore, hub genes were comprehensive...
Abstract Background Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of tumors for which the overall survival rate worldwide around 60%. The tumor microenvironment, including cancer-associated fibroblasts (CAFs), believed to affect treatment response migration HNSCC. aim this study was create biologically relevant HNSCC in vitro model consisting both cells CAFs cultured 3D establish predictive biomarkers response, as well investigate impact on phenotype, proliferation...
Background: The aim of this study was to evaluate biomarkers and biological characteristics tumor biopsies from patients with head neck cancer (HNC) assess the risk early death. Furthermore, we analyzed whether any combination markers could be used for prognostication death within six months after diagnosis. Materials Methods: Patients diagnosed HNC, receiving curative treatment decision at a multidisciplinary board meeting, who died diagnosis were included in study. Nine identified matched...
Apoptin, a protein from the chicken anemia virus, has attracted attention because it specifically kills tumor cells while leaving normal unharmed. The reason for this selectivity is unclear and depends on subcellular localization, as apoptin resides in cytoplasm of but nuclei transformed cells. It was shown that nuclear localization tumor-specific killing crucially require apoptin's phosphorylation by an yet unknown kinase. Here we elucidate pathway apoptin-induced apoptosis show essentially...
The voltage-dependent anion channels (VDAC) play an essential role in the cross talk between mitochondria and rest of cell. Their implication cell life death has been studied extensively recent years. In this work we impact mitochondrial membrane (VDACs) on survival response to X-ionizing radiation (IR) human lymphoblastoid K562 cells.The inhibition VDACs was achieved by 4,4`-diisothiocyanostilbene-2,2`-disulfonic acid (DIDS) inhibitor vitro experiments including clonogenity assay,...