A5015174059- Cell death mechanisms and regulation
- Autophagy in Disease and Therapy
- RNA Interference and Gene Delivery
- Cancer-related Molecular Pathways
- Tissue Engineering and Regenerative Medicine
- Ubiquitin and proteasome pathways
- PI3K/AKT/mTOR signaling in cancer
- Phagocytosis and Immune Regulation
- Endoplasmic Reticulum Stress and Disease
- Electrospun Nanofibers in Biomedical Applications
- Virus-based gene therapy research
- Cancer Cells and Metastasis
- Mesenchymal stem cell research
- Cancer, Hypoxia, and Metabolism
- Bone Tissue Engineering Materials
- PARP inhibition in cancer therapy
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Mitochondrial Function and Pathology
- CRISPR and Genetic Engineering
- Animal Virus Infections Studies
- Nuclear Receptors and Signaling
- Protease and Inhibitor Mechanisms
- RNA regulation and disease
- Pluripotent Stem Cells Research
Koszalin University of Technology
2025
Silesian University of Technology
2018-2024
Pomeranian Medical University
2013-2024
Shiraz University of Medical Sciences
2020-2023
Singapore Eye Research Institute
2023
Montavid Thermodynamic Research Group
2023
Netherlands Comprehensive Cancer Organisation
2021
University of Manitoba
2005-2020
Centre de Biophysique Moléculaire
2017-2020
Centre National de la Recherche Scientifique
2017-2020
Mice lacking the gene encoding poly(ADP-ribosyl) transferase (PARP or ADPRT) display no phenotypic abnormalities, although aged mice are susceptible to epidermal hyperplasia and obesity in a mixed genetic background. Whereas embryonic fibroblasts PARP exhibit normal DNA excision repair, they grow more slowly vitro. Here we investigated putative roles of cell proliferation, death, radiosensitivity, recombination, as well chromosomal stability. We show that proliferation deficiency vitro vivo...
Death ligands not only induce apoptosis but can also trigger necrosis with distinct biochemical and morphological features. We recently showed that in L929 cells CD95 ligation induces apoptosis, whereas TNF elicits necrosis. Treatment anti-CD95 resulted typical characterized by caspase activation DNA fragmentation. These events were barely induced TNF, although triggered cell death to a similar extent as CD95. Surprisingly, the inhibitor zVAD prevented CD95-mediated it potentiated...
Abstract The complex formed by two members of the S100 calcium-binding protein family, S100A8/A9, exerts apoptosis-inducing activity against various cells, especially tumor cells. Here, we present evidence that S100A8/A9 also has cell growth-promoting at low concentrations. Receptor advanced glycation end product (RAGE) gene silencing and cotreatment with a RAGE-specific blocking antibody revealed this was mediated via RAGE ligation. To investigate signaling pathways, MAPK phosphorylation...
Myeloic cells express a peculiar surface receptor for extracellular ATP, called the P2Z/P2X 7 purinoreceptor, which is involved in cell death signalling. Here, we investigated role of caspases, family proteases implicated apoptosis and cytokine secretion. We observed that ATP induced activation multiple caspases including caspase‐1, ‐3 ‐8, subsequent cleavage caspase substrates PARP lamin B. Using inhibitors, it was found were specifically ATP‐induced apoptotic damage such as chromatin...