A5055330752- Autophagy in Disease and Therapy
- Cancer, Lipids, and Metabolism
- Lipoproteins and Cardiovascular Health
- Nerve injury and regeneration
- Glioma Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Ferroptosis and cancer prognosis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- 3D Printing in Biomedical Research
- RNA Interference and Gene Delivery
- Sirtuins and Resveratrol in Medicine
- Cancer, Hypoxia, and Metabolism
- Mathematical Biology Tumor Growth
- Lipid metabolism and biosynthesis
- Cancer Cells and Metastasis
- Reproductive System and Pregnancy
- Sphingolipid Metabolism and Signaling
- Cell Image Analysis Techniques
- Retinoids in leukemia and cellular processes
- COVID-19 Clinical Research Studies
- Nutritional Studies and Diet
- Plant biochemistry and biosynthesis
- Peroxisome Proliferator-Activated Receptors
- Cholesterol and Lipid Metabolism
- Inflammasome and immune disorders
University of Manitoba
2017-2025
University of Victoria
2019-2025
Mashhad University of Medical Sciences
2024
Isfahan University of Medical Sciences
2016-2021
Children's Hospital Research Institute of Manitoba
2018
National Institute of Genetic Engineering and Biotechnology
2018
Shiraz University of Medical Sciences
2013-2015
Research Institute for Endocrine Sciences
2011
Idiopathic pulmonary fibrosis (IPF) is a lethal fibrotic lung disease in adults with limited treatment options. Autophagy and the unfolded protein response (UPR), fundamental processes induced by cell stress, are dysregulated fibroblasts epithelial cells from humans IPF. Human primary cultured parenchymal airway non-IPF IPF donors were stimulated transforming growth factor-β1 (TGF-β1) or without inhibitors of autophagy UPR (IRE1 inhibitor). Using immunoblotting, we monitored temporal changes...
Temozolomide (TMZ) is a chemotherapy agent used to treat Grade IV astrocytoma, also known as glioblastoma (GBM). TMZ treatment causes DNA damage that results in tumor cell apoptosis and increases the survival rate of GBM patients. However, chemoresistance result TMZ‐induced autophagy significantly reduces this anticancer effects over time. Statins are competitive inhibitors HMG‐CoA reductase, rate‐limiting enzyme mevalonate (MEV) cascade. best for their cholesterol (CH)‐lowering effect....
Glioblastoma (GBM) is the most prevalent malignant primary brain tumor with a very poor survival rate. Temozolomide (TMZ) common chemotherapeutic agent used for GBM treatment. We recently demonstrated that simvastatin (Simva) increases TMZ-induced apoptosis via inhibition of autophagic flux in cells. Considering role unfolded protein response (UPR) pathway regulation autophagy, we investigated involvement UPR Simva–TMZ-induced cell death by utilizing highly selective IRE1 RNase activity...
Medulloblastoma is a common pediatric brain tumor and one of the main types solid cancers in children below age 10. Recently, cholesterol-lowering “statin” drugs have been highlighted for their possible anti-cancer effects. Clinically, statins are reported to promising potential consideration as an adjuvant therapy different cancers. However, effects medulloblastoma cells not currently well-defined. Here, we investigated cell death mechanisms by which simvastatin mediates its on human lines....
Hydrogel structures with microscale morphological features have extensive application in tissue engineering owing to their capacity induce desired cellular behavior. Herein, we describe a novel biofabrication method for fabrication of grooved solid and hollow hydrogel fibers control over cross-sectional shape, surface morphology, porosity, material composition. These were further configured into three-dimensional using textile technologies such as weaving, braiding, embroidering methods....
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2) infection has profoundly affected the lives of millions people. To date, there is no approved vaccine or specific drug to prevent treat COVID-19, while globally spreading at an alarming rate. Because development effective vaccines novel drugs could take several months (if not years), repurposing existing considered a more efficient strategy that save now. Statins constitute class...
The placenta is a dynamic and complex organ that plays an essential role in the health development of fetus. Placental disorders can affect both mother There currently unmet clinical need to develop nanoparticle-based therapies target treat placental disorders. However, little known about interaction nanoparticles (NPs) with human under biomimetic conditions. Specifically, impact shear stress exerted on trophoblasts (placental epithelial cells) by maternal blood flow, gradual fusion along...
Macroautophagy/autophagy is a crucial cellular process for degrading and recycling damaged proteins organelles, playing significant role in diseases such as cancer neurodegeneration. Evaluating autophagy flux, which tracks autophagosome formation, maturation, degradation, essential understanding disease mechanisms. Current fluorescence‐based methods are resource‐intensive, requiring advanced equipment expertise, limiting their use clinical laboratories. Here, we introduce non‐fluorescent...
Glioblastoma (GB), an aggressive brain malignancy with a poor prognosis of 1.5-2 years, rarely exhibits extracranial metastasis (ECM). However, metabolic reprogramming has emerged as key driver GB progression and invasiveness. This study presents rare case recurrent scalp metastasis, exploring how shifts enable cells to evade treatment adapt hostile environments, offering insights for developing innovative therapies. Tandem mass spectrometry (MS/MS) was employed analyze amino acid profiles...