A5007396724- Neuropeptides and Animal Physiology
- Nerve injury and regeneration
- Pain Mechanisms and Treatments
- Sirtuins and Resveratrol in Medicine
- Biochemical effects in animals
- Adipose Tissue and Metabolism
- Epigenetics and DNA Methylation
- Cancer, Stress, Anesthesia, and Immune Response
- Pharmacological Effects of Medicinal Plants
- Trace Elements in Health
- Pharmacological Effects and Toxicity Studies
- Tryptophan and brain disorders
- Natural Antidiabetic Agents Studies
- Dermatologic Treatments and Research
- Ginger and Zingiberaceae research
- Epilepsy research and treatment
- Hair Growth and Disorders
- Aldose Reductase and Taurine
- Saffron Plant Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Signaling Pathways in Disease
- Heavy Metal Exposure and Toxicity
- Dyeing and Modifying Textile Fibers
- Curcumin's Biomedical Applications
Shiraz University of Medical Sciences
2015-2024
Background: Colorectal cancer (CRC) is one of the leading causes death worldwide and increasingly recognized as a heterogeneous disease at molecular level. The autophagy-related 5 (ATG5) light chain 3 (LC3B) genes are involved in autophagy pathway play crucial roles physiological processes, including adaptation to starvation, prevention neurodegeneration, expression intracellular antigens, tumor suppression. Objectives: This study aimed elucidate epigenetic alterations ATG5 LC3B analyze...
Background. Alopecia areata (AA) is an autoimmune condition, in which hair lost from some areas of the body. Though its etiopathogenesis not fully understood, there are claims that imbalance trace elements may trigger onset AA, by distorting immune functions. In this study, we tried to investigate relationship between AA and iron, zinc, copper levels serum hair. Materials Methods. Sixteen female patients with (14-40 years old) 27 healthy controls were enrolled study. Serum level measured...
Introduction: Vitiligo is a chronic skin disease, which its etiopathogenesis not fully understood. Numerous studies have suggested that oxidative stress may play role in the pathophysiology of vitiligo. There are controversial reports as to changes serum trace elements, copper and zinc levels vitiligo patients. Objective: In this study, we evaluated alterations level Cu Zn among group Iranian Methods: The were compared between 117 patients 137 healthy controls using atomic absorption...
Previous studies have provided strong evidence for the anticancer activity of berry fruits.In this study, we investigated effects blackberry juice and three berry- polyphenolic compounds on cell proliferation telomerase in human hepatoma HepG2 normal peripheral blood mononuclear cells (PBMCs).The viability were measured by MTT TRAP assay, respectively. Berry expression genes determined quantitative RT-PCR assay.Blackberry, gallic acid, resveratrol inhibited both PBMC a dosedependent manner....
<b><i>Background:</i></b> Epigenetic mechanisms such as histone modifications may be involved in the structural and behavioral changes associated with addiction. We studied whether morphine-induced mRNA levels of catecholamine biosynthesis enzyme, tyrosine hydroxylase (TH), are around promoter this gene locus coeruleus (LC) ventral tegmental area (VTA) rats. <b><i>Methods:</i></b> Dependence was induced rats by intraperitoneal injections...
Despite effective anticancer effects, the use of doxorubicin (DOX) is hindered due to its cardio and neurotoxicity. The neuroprotective effect adrenomedullin (AM) was shown in several studies. present study aimed evaluate possible protective effects AM against DOX-induced toxicity dorsal root ganglia (DRGs) neurons.Rat embryonic DRG neurons were isolated cultured. various concentrations DOX (0.0 100 µM) absence or presence (3.125 -100 nM) on cell death, apoptosis, oxidative stress,...
The main objective of the present study is to find out loose links between prescription medication and its utilization in pediatric department, especially with drugs that belong antiepileptic category.This prospective observational was carried for 6 months Department Pharmacy Practice, Tertiary Care Hospital, Bangalore. conducted on 100 patients receiving medication. patient demographics all medically relevant information were noted a predefined data collection form.The showed maximum number...
The study aims to show the possible anxiolytic and antidepressant-like properties of an oral lavender’s flower aqueous extract (LAE) in chronic mild stress (CMS) model rats. Test control rats received LAE (200 or 400 mg/ kg) distilled water respectively. Tests Sucrose preference (SP), elevated plus maze (EPM), open field (OFT) were used evaluate rats’ behavioral changes. percentage SP CMS group was 2.6 times less than that unstressed (p<0.05). However, administration mg...
The role of oxidative stress in female fertility is a compelling area for research. According to traditional medicine, Cichorium intybus, known as Kasni, believed improve fertility. For this purpose, the effects C. intybus distillate (CI) on blood antioxidant status were assessed rats with carbon tetrachloride (CCl4)-induced toxicity. assigned four experimental groups Control, CI, CCl4, and CI+CCl410 (n=10 each group). level enzymes, such glutathione peroxidase (GPx), reductase (GR),...
Adrenomedullin (AM) has high expression in the spinal cord. In this study, we investigated of AM and its receptor components, including calcitonin receptor-like (CLR) activity modifying proteins (RAMPs) dorsal root ganglion (DRG) motor (SM) neurons. Furthermore, effects on cAMP/cAMP response element-binding protein (CREB), AKT/glycogen synthase kinase-3 beta (GSK-3β) signaling pathways, expressions brain-derived neurotrophic factor (BDNF) neurotrophin-3 (NT-3) were evaluated.Rat embryonic...