A5012191048- Salivary Gland Tumors Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Protease and Inhibitor Mechanisms
- Cancer, Hypoxia, and Metabolism
- Chemokine receptors and signaling
- Cancer Cells and Metastasis
- Cytokine Signaling Pathways and Interactions
- Neuroblastoma Research and Treatments
- Psoriasis: Treatment and Pathogenesis
- Immunotherapy and Immune Responses
- Ovarian cancer diagnosis and treatment
- Retinal Diseases and Treatments
- Reproductive System and Pregnancy
- IL-33, ST2, and ILC Pathways
- Proteoglycans and glycosaminoglycans research
- Toxin Mechanisms and Immunotoxins
- Occupational and environmental lung diseases
- Vitamin D Research Studies
- Endometriosis Research and Treatment
- Liver Disease Diagnosis and Treatment
- Tumors and Oncological Cases
- Thyroid Cancer Diagnosis and Treatment
- Systemic Sclerosis and Related Diseases
Shiraz University of Medical Sciences
2016-2025
Khalili Hospital
2022
Institute of Cancer Research
2014
Mashhad University of Medical Sciences
2012
Baqiyatallah University of Medical Sciences
2011
European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene.
OBJECTIVE: Liver is the primary site for metastasis from colorectal cancer (CRC). It has been proposed that carcinoembryonic antigen (CEA) might have an instrumental role in development of hepatic human CRC. The aim present study was therefore to investigate assoc iation between preoperative serum CEA concentrations and incidence synchronous CRC-liver metastasis. METHODS: A total 199 patients with CRC who underwent radical surgery at Shiraz University hospitals were enrolled this study....
Background: Osteopontin (OPN) is involved in various biological functions, including cancer pathogenesis and metastasis. However, its clinical value salivary gland tumors (SGTs) has received little attention. Therefore, this study aimed to evaluate the connection between OPN serum levels clinicopathologic features of benign malignant SGTs Iranian patients. Methods: This cross-sectional a total 90 patients with SGTs, (n=60) (n=30) cases. The control group consisted 60 healthy individuals...
Background: MMP-3 is a proteolytic enzyme of the matrix metalloproteinase family. Protein degradation which their fundamental action regulates different activities tumor cell such as growth, differentiation, apoptosis, migration, invasion, angiogenesis well resistance to immune system. Aim: The aim this study was determine serum levels in patients with OSCC and investigate if they correlate clinicopathological features. Method materials: Using an ELISA kit, we assessed compared circulating...
There is a Th1/Th2 cytokine imbalance and expression of IL-17 in patients with brain tumours. We aimed to compare the levels IL-17A IL-6 sera glioma, meningioma schwannoma as well healthy individuals.IL-17A were measured 38 24 18 for comparison 26 controls by commercial ELISA assays.We observed an increase 30% glioma while only 4% 5.5% none showed elevated their (0.29 ± 0.54, 0.03 0.15 0.16 0.68 vs. 0.00 pg/ml; p=0.01, p=0.01 p=0.001, respectively). was also significant decrease level...
Background: Overexpression of human leukocyte antigen G (HLA-G) and increased plasma levels soluble HLA-G (sHLA-G) have been reported in different malignancies, are believed to be involved tumor immune evasion. Objectives: This study was designed evaluate the expression tissues sHLA-G patients with gastrointestinal cancer, determine their associations clinicopathological factors. The link between Helicobacter pylori infection or also investigated gastric cancer. Methods: from 100 colorectal...
Vascular endothelial growth factor (VEGF) is known as a fundamental regulator of angiogenesis that accelerates cellular proliferation, vascular permeability, and cell migration an inhibitor apoptosis. Extracellular matrix degradation by metalloproteinase (MMP) necessary for migration, metastasis. Accordingly, the objective present study was to determine circulating levels VEGF MMP3 their relation in patients with oral squamous carcinoma. Using ELISA kit, MMP-3 sera 45 carcinoma (OSCC)...
Aim: The interrelation between nicotine and IL-17A in bladder cancer (BC) patients was investigated. Methods: the sera of 121 BC who smoked nicotine, 80 nonsmoker patients, 29 30 age- sex-matched healthy smokers nonsmokers were also measured. Results: elevated smoker compared with controls (p = 0.004 p 0.004, respectively). level both water pipes cigarettes highest (4.35±8.57 pg/ml), followed by pipe users only (1.33±3.122 pg/ml) cigarette (0.79±2.26 pg/ml, 0.001). lower stages (I II) higher...
To investigate the serum level of brain-derived neurotrophic factor (BDNF) in age-related macular degeneration (AMD) and healthy control subjects. The disruption tight balance neuroinflammatory neuroprotective processes an immune-privileged site like retina is proposed to contribute pathogenesis AMD. One main mediators central nervous system BDNF with its notably affected several neurodegenerative disorders.Thirty-six patients AMD 36 age-matched controls were enrolled this study. was...
Breast cancer cells and tumor stroma produce different cytokines soluble factors. Cytokines, while playing crucial roles in immune responses to tumors, also favour growth progression. IL-7 G-CSF are two that may exert influences on the pathophysiology of breast cancer.Sera were collected from 136 females with before receiving chemotherapy or radiotherapy. The control group comprised 60 healthy age-matched without any acute chronic diseases no family history cancer. Serum levels measured by...
Although, over the past few years, application of mammography has risen up sharply in Iran, very little, if any, been reported extent patient's dose from this type imaging. The purpose study was to establish local diagnostic reference level (DRL) arising great Khorasan province Iran. It is generally assumed that glandular tissue most vulnerable breast tissue. Therefore, mean (MGD) widely accepted as appropriate dosimetric quantity predict risk radiation-induced cancer. Literary, DRL for...
The association between HER2 Ile655Val single nucleotide polymorphism and cancer is controversial.The aim of our study was to investigate this in patients with ovarian cancer.Genomic DNA extracted from peripheral blood leukocytes 107 130 healthy women. gene assessed by PCR-RFLP.No significant difference observed genotype allele frequency patient control groups according polymorphism. disease stage, age, histological type were also not associated the polymorphism.Our data showed that...
Background: Mast cells can influence tumor progression via different pathways and increased mast cell density has been demonstrated in oral squamous carcinoma (OSCC). It shown that the serum tryptase level is elevated with some malignant tumours may thus be a useful parameter. However, there are no data available about OSCC. The main aim of this study was evaluation (MCT) OSCC patient serum. Materials Methods: In cross-sectional, analytic study, circulating levels MCT were assessed sera 55...
Environmental, genetic, and immunological factors may play a role in the pathogenesis of age-related macular degeneration (AMD). In an attempt to better understand AMD, this study, we evaluated serum interferon (IFN) levels patients with AMD compared it persons without AMD.In case-control 42 healthy individuals (without AMD) were enrolled as case control groups, respectively. The two groups matched regarding their age sex. We classified group dry-type wet-type AMD. Blood samples obtained was...
<b><i>Background:</i></b> CD138/Syndecan-1 (Sdc-1) is expressed on the tumor and stromal cells of invasive bladder carcinoma. CD138/Sdc-1 shedding from cell surface associated with phenotype in lung breast cancers. <b><i>Patients Methods:</i></b> Soluble was measured sera 86 cancer patients 57 healthy individuals by a commercial ELISA assay. <b><i>Results:</i></b> Sdc-1 increased (138.42 ± 81.85 vs. 86.48 82.58 ng/ml, p...
Occupational exposures to respirable synthetic vitreous fiber (SVF) and dust are associated with many lung diseases including cancer. Low-dose computed tomography is used for screening patients who highly suspicious of having carcinoma. However, it seems not be cost-effective. Serum biomarkers could a useful tool the surveillance occupational exposure, by providing possibility diagnosing cancer in its early stages.To determine if serum carcinoembryonic antigen (CEA) cytokeratin fragment...
Background: Inflammation plays a major role in the development and progression of gastric other gastrointestinal tumors. The IL-17 family cytokines has been under investigation as targets immunotherapy. Materials Methods: We investigated levels IL-17A inflammatory cytokine sera 57 patients with cancer (GC) 90 healthy age/sex matched controls using ELISA methods. Results: In only 5 (8.8%) patients' was detectable. No apparent controls. maximum concentration 7.004 pg/ml. Vascular lymphatic...
Role of interleukin 17A (IL-17A) in carcinogenesis and cancer growth is controversial. Although some researches support its antitumor activity, others suggest that it promotes the development different types including skin by activation STAT3. function cytokines such as IL-17A has been extensively studied various cancer, nonmelanoma (NMSC) not received much attention. Therefore, present study was aimed to investigate serum levels NMSC patients. This cross-sectional performed on 60 patients...
Different factors are involved in the incidence, etiology, metastasis, diagnosis, and treatment of oral squamous cell carcinoma, including apoptosis inhibitor proteins. Baculoviral IAP repeat containing protein 6 (BIRC6) is one proteins contributing to cancer cells' survival many types with diagnostic importance. This study aimed at assessing serum level BIRC6 carcinoma.In this retrospective cross-sectional study, 60 samples were collected from 45 male 15 female patients a mean age 61 years...
Neoangiogenesis is essential for tumor development, invasion, and dissemination. The most potent of the cytokines associated with angiogenesis vascular endothelial growth factor (VEGF). aim present study was to determine VEGF serum level in patients salivary gland tumor. Using an ELISA kit, circulating levels sera from 58 30 healthy controls were assessed. Mean tumors (574.9 ± 414.3) significantly higher than those (263.9 310.0) (P = 0.009). Within group, mean concentration malignant (n 27)...