A5006253107- Chronic Obstructive Pulmonary Disease (COPD) Research
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Pediatric health and respiratory diseases
- Asthma and respiratory diseases
- Neuroscience of respiration and sleep
- Adipokines, Inflammation, and Metabolic Diseases
- Health, psychology, and well-being
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Diet and metabolism studies
- Childhood Cancer Survivors' Quality of Life
- Neuroscience and Neuropharmacology Research
- Nutrition and Health in Aging
- Inhalation and Respiratory Drug Delivery
- Neonatal and fetal brain pathology
- Gut microbiota and health
- Alzheimer's disease research and treatments
Utrecht University
2018-2022
University of Göttingen
2018
Radboud University Nijmegen
2017
Radboud University Medical Center
2017
Chronic obstructive pulmonary disease (COPD) is often associated with intestinal comorbidities. In this study, changes in homeostasis and immunity a cigarette smoke (CS)- lipopolysaccharide (LPS)-induced COPD model were investigated. Mice exposed to or air for 72 days, except days 42, 52, 62 on which the mice treated saline LPS via intratracheal instillation. Cigarette exposure increased airway inflammatory cell numbers, mucus production, different mediators, including C-reactive protein...
Animal models are still vital in the field of respiratory disease research. To improve accuracy and consistency dose specific compounds administered specifically tract, it is important to optimize compare technique currently available techniques. In this study, an optimized intubation-mediated intratracheal administration (IMIT) described compared oropharyngeal aspiration (OA). Adult female Balb/c mice were treated with Evans Blue using IMIT or OA sacrificed after a short recovery observe...
Brain-related comorbidities are frequently observed in chronic obstructive pulmonary disease (COPD) and related to increased progression mortality. To date, it is unclear which mechanisms involved the development of brain-related problems COPD. In this study, a cigarette smoke lipopolysaccharide (LPS) exposure murine model was used induce COPD-like features assess impact on brain behavior. Mice were daily exposed for 72 days, except days 42, 52, 62, mice intratracheally bacterial trigger...
Adipose tissue (AT) has a modulating role in obesity-induced metabolic complications like type 2 diabetes mellitus (T2DM) via the production of so-called adipokines such as leptin, adiponectin, and resistin. The are believed to influence other tissues affect insulin resistance, liver function, increase risk T2DM. In this study, we examined impact intervention with short-chain fatty acid butyrate following high-fat diet (HFD) on AT function factors associated obesity T2DM mice during mid-...
Chronic obstructive pulmonary disease (COPD), often caused by smoking, is a chronic lung with systemic manifestations including metabolic comorbidities. This study investigates adaptive and pathological alterations in adipose skeletal muscle tissue following cigarette smoke exposure using vivo vitro models. Mice were exposed to or air for 72 days the pre-adipose cell line 3T3-L1 was utilized as an model. Cigarette decreased body weight, proportional loss fat mass more pronounced than lean...
The N-terminally truncated pyroglutamate Aβ3-42 (AβpE3-42) and Aβ4-42 peptides are known to be highly abundant in the brain of Alzheimer's disease (AD) patients. Both show enhanced aggregation neurotoxicity comparison full-length Aβ, suggesting that these amyloid may play an important role pathogenesis AD. aim present work was study direct effect combination AβpE3-42 on ongoing AD-related neuron loss, pathology, neurological deficits transgenic mice. Bigenic mice were generated by crossing...
Chronic obstructive pulmonary disease (COPD) caused by cigarette smoke (CS) is featured oxidative stress and chronic inflammation. Due to the poor efficacy of standard glucocorticoid therapy, new treatments are required. Here, we investigated whether novel compound SUL-151 with mitoprotective properties can be used as a prophylactic therapeutic treatment in murine CS-induced inflammation model. (4 mg/kg), budesonide (500 μg/kg), or vehicle were administered via oropharyngeal instillation...
One cluster of the extrapulmonary manifestations in chronic obstructive pulmonary disease (COPD) is related to brain, which includes anxiety, depression and cognitive impairment. Brain-related comorbidities are worsening symptoms increased mortality COPD patients. In this study, a murine model was used examine effects emphysema repetitive inflammatory events on systemic outcomes brain function. addition, effect dietary intervention brain-related parameters assessed. Adult male C57Bl/6J mice...
Background: Chronic obstructive pulmonary disease (COPD) is often accompanied by psychiatric problems, such as depression and anxiety, affecting both treatment outcomes mortality. Evidence for the number of COPD patients using medication these disorders sparse. In this study, chronic antidepressant (ATD) anxiolytic (ANX) drug use – to identify anxiety among was compared with subjects or without other diseases. Methods: The NControl database containing prescription data 800 pharmacies...
<b>Introduction:</b> Chronic obstructive pulmonary disease (COPD) is often associated with intestinal comorbidities, which considerably influence prognosis and clinical outcomes. However, the involvement of gut, as well cross-talk between gut lung, in immuno-pathophysiology COPD has hardly been investigated. <b>Aim:</b> In this study, changes homeostasis immunity a cigarette smoke-induced murine model for have <b>Methods:</b> Mice were exposed to smoke or air 72 days. The pathophysiology...