A5015054965- Chronic Obstructive Pulmonary Disease (COPD) Research
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Respiratory Support and Mechanisms
- Neuroscience of respiration and sleep
- Virus-based gene therapy research
Princess Máxima Center
2024
Utrecht University
2022
Oncolytic viruses (OVs) are characterised by their preference for infecting and replicating in tumour cells either naturally or after genetic modification, resulting oncolysis. Furthermore, OVs can elicit both local systemic anticancer immune responses while specifically lysing cells. These characteristics render them a promising therapeutic approach paediatric brain tumours (PBTs). PBTs frequently marked cold microenvironment (TIME), which suppresses immunotherapies. Recent preclinical...
One cluster of the extrapulmonary manifestations in chronic obstructive pulmonary disease (COPD) is related to brain, which includes anxiety, depression and cognitive impairment. Brain-related comorbidities are worsening symptoms increased mortality COPD patients. In this study, a murine model was used examine effects emphysema repetitive inflammatory events on systemic outcomes brain function. addition, effect dietary intervention brain-related parameters assessed. Adult male C57Bl/6J mice...