A5103148498- Microplastics and Plastic Pollution
- biodegradable polymer synthesis and properties
- Graphene and Nanomaterials Applications
- Autophagy in Disease and Therapy
- Microbial Community Ecology and Physiology
- Circadian rhythm and melatonin
- Endoplasmic Reticulum Stress and Disease
- Air Quality and Health Impacts
- Liver Disease Diagnosis and Treatment
- Bacterial Genetics and Biotechnology
- Advanced Vision and Imaging
- Advanced Neuroimaging Techniques and Applications
- Effects and risks of endocrine disrupting chemicals
- Advanced Glycation End Products research
- Remote Sensing and LiDAR Applications
- Diet, Metabolism, and Disease
- Mitochondrial Function and Pathology
- Psychological and Temporal Perspectives Research
- Impact of Light on Environment and Health
- Advanced MRI Techniques and Applications
- Bone health and treatments
- Recycling and Waste Management Techniques
- Sesame and Sesamin Research
- Pancreatic function and diabetes
- Bone and Joint Diseases
Peking University
2023-2025
Chinese Research Academy of Environmental Sciences
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Zhejiang Chinese Medical University
2023-2024
Tsinghua University
2017-2024
Harbin Normal University
2023
Shenzhen Stock Exchange
2022
Center for Life Sciences
2017-2020
Jiangxi Provincial People's Hospital
2019
Nanchang University
2019
Human health is being threatened by environmental microplastic (MP) pollution. MPs were detected in the bloodstream and multiple tissues of humans, disrupting regular physiological processes organs. Nanoscale plastics can breach blood-brain barrier, leading to neurotoxic effects. How cause brain functional irregularities remains unclear. This work uses high-depth imaging techniques investigate within vivo. We show that circulating are phagocytosed lead these cells obstruction capillaries...
Environmental light pollution adversely affects brain function, disturbing circadian rhythms and negatively impacting human health. Nanoplastics (NPs) is pervasive in the environment, their minuscule size facilitates entry into body, particularly invading compromising its functionality. However, whether NPs infiltrate rhythm-regulated regions disrupt organisms remains unclear. Our study demonstrates that exposure to mice perturbs normal rhythms. Specifically, invade suprachiasmatic nucleus...
Microplastics (MPs) can accumulate in animal organs. Numerous studies have linked MPs with immune system. However, the impact of on response remains unclear. This study examined innate mice exposed to 5 μm MPs. In lipopolysaccharide challenge, treated exhibited lower levels serum factors and activated cells. disrupted immune-related receptors cause dysfunction cell signal transduction within liver spleen. Proteomic analysis revealed that impede activation signals. addition, tissue section...
Nutrients stimulate the anabolic synthesis of proteins and lipids, but selective insulin resistance in obesity biases program toward lipogenesis. Here, we report identification a DNAJB9-driven that favors protein energy production over lipid accumulation. We show there are two pools DNAJB9 cochaperone. ER lumen promotes degradation lipogenic transcription factor SREBP1c through ERAD, whereas its counterpart on membrane assembly mTORC2 cytosol stimulates ATP. The expression Dnajb9 is induced...
Abstract Both iron overload and deficiency have been reported in obesity metabolic syndromes. Due to the presence of multiple intracellular pools dynamic nature mobilization use, actual status contribution free metabolically active toward syndrome remain be established. The discovery nuclear receptor coactivator 4 (NCOA4) as a ferritinophagy provides an opening address connection between diseases. This study aims specifically dissect role hepatic lipid metabolism steatosis. We conducted...
The study attempted to explore the pathological mechanisms of glucocorticoid (GC)-associated osteonecrosis femoral head (GONFH) and investigate efficacy exact mechanism naringenin (NAR), a natural flavonoid compound, in treating GONFH. RNA sequencing was conducted GONFH identify potential therapeutic factors NAR. levels autophagy apoptosis were examined clinical, animal, mesenchymal stem cells (MSCs) samples, revealing remarkable increases both group. In addition, effects rapamycin (RAPA, an...
Abstract Aging is usually accompanied by excessive body fat gain, leading to increased susceptibility comorbidities. This study aimed explore an unexpected function for the eukaryotic initiation factor‐2α (eIF2α) during aging. Reducing eIF2α dose led a reconfiguration of metabolic equilibrium, promoting catabolism, facilitating lipolysis, and decreasing accumulation while maintaining healthy glucose lipid metabolism Specifically, enhanced expression distinct messenger RNAs encoding...
Most eukaryotes exhibit diurnal rhythms in their metabolism, growth, and cell cycle control to accommodate the 24-hour light-dark cycles on earth surface. Circadian rhythm is not a passive response exposure of sunlight, but driven by an internal, automated clock system, i.e. circadian clock. The comprised multiple feedback loops levels transcription, translation, post-translational modification. Just like any clock, can be reset, entrained, environmental/external factors, including light,...
The operation condition of transmission line determines the power supply quality and reliability system. Therefore, it is necessary to make real-time safety monitoring on line. based 3D scene fusion, this paper studies video monitoring. Firstly, introduces three-dimensional virtual technology, expounds key technologies required in Finally, performance tested. test results show that communication distance points very stable, basically maintained at 1.8m/s, indicating meets design requirements...