A5080069591- Hemophilia Treatment and Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood Coagulation and Thrombosis Mechanisms
- Spine and Intervertebral Disc Pathology
- Neurogenetic and Muscular Disorders Research
- Chronic Myeloid Leukemia Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Opinion Dynamics and Social Influence
- Osteoarthritis Treatment and Mechanisms
- Bone health and treatments
- Pregnancy-related medical research
- Pharmacological Effects of Natural Compounds
- Musculoskeletal pain and rehabilitation
- Cancer-related gene regulation
- Rheumatoid Arthritis Research and Therapies
- Bone and Joint Diseases
- Medicinal Plant Pharmacodynamics Research
- Bone Metabolism and Diseases
- Healthcare and Venom Research
- RNA modifications and cancer
- Cytokine Signaling Pathways and Interactions
- Adrenal and Paraganglionic Tumors
- Hair Growth and Disorders
- MicroRNA in disease regulation
- Hematological disorders and diagnostics
Zhejiang Chinese Medical University
2021-2024
Weatherford College
2024
Second Affiliated Hospital of Zhejiang University
2024
Background: Intervertebral disc degeneration (IDD) is a major cause of lower back pain (LBP), in which inflammatory frequently involved. Amygdalin (AMD) naturally occurring compound that exerts anti-fibrotic, anti-inflammatory, analgesic, and immunomodulatory effects various diseases. The purpose this study was to investigate the therapeutic molecular mechanisms AMD on Lumbar spine instability (LSI)-induced IDD mice. Methods: In study, we first explored vivo, then further mechanism its both...
Recurrent joint bleeding in hemophilia patients frequently causes hemophilic arthropathy (HA). Drastic degradation of cartilage is a major characteristic HA, but its pathological mechanisms has not yet been clarified. In HA cartilages, we found server matrix and increased expression DNA methyltransferase proteins. We thus performed genome-wide methylation analysis on human (N=5) osteoarthritis (OA) articular identified 1228 differentially methylated regions (DMRs) associated with HA....
Abstract The regulatory mechanisms involved in embryonic development are complex and yet remain unclear. SCP4 represents a novel nucleus‐resident phosphatase identified our previous study. primary aim of this study was to elucidate the function progress cartilage endochondral osteogenesis. −/− Col2ER mice were constructed assess differences bone formation using whole skeleton staining. ABH/OG staining used compare chondrocyte differentiation development. Relevant biological functions...
Recurrent joint bleeding in hemophilia patients frequently results hemophilic arthropathy (HA). Drastic degradation of articular cartilage is a major characteristic HA, but its pathological mechanisms has not yet been clarified. Here, we conducted genome-wide DNA methylation study with the goal identifying critical genes for HA degeneration.DNA was isolated from human osteoarthritis (N = 5) and cartilages analyzed using Infinium Human Methylation 850 BeadChip array. Adeno-associated...
Recurrent joint bleeding in hemophilia patients frequently causes hemophilic arthropathy (HA). Drastic degradation of cartilage is a major characteristic HA, but its pathological mechanisms has not yet been clarified. In HA cartilages, we found server matrix and increased expression DNA methyltransferase proteins. We thus performed genome-wide methylation analysis on human (N=5) osteoarthritis (OA) articular identified 1228 differentially methylated regions (DMRs) associated with HA....
Adrenal cellular schwannomas are exceptionally rare stromal tumors that often misdiagnosed due to the lack of specific radiological, serological, or clinical features. In this report, we describe differential diagnosis a adrenal schwannoma.
The study attempted to explore the pathological mechanisms of glucocorticoid (GC)-associated osteonecrosis femoral head (GONFH) and investigate efficacy exact mechanism naringenin (NAR), a natural flavonoid compound, in treating GONFH. RNA sequencing was conducted GONFH identify potential therapeutic factors NAR. levels autophagy apoptosis were examined clinical, animal, mesenchymal stem cells (MSCs) samples, revealing remarkable increases both group. In addition, effects rapamycin (RAPA, an...
Recurrent joint bleeding in patients with hemophilia frequently results hemophilic arthropathy (HA). Drastic degradation of articular cartilage is a major characteristic HA, but its pathological mechanisms has not yet been clarified. Here, we conducted genome-wide DNA methylation study the goal identifying critical genes for HA degeneration.DNA was isolated from human osteoarthritis (N = 5) and cartilages analyzed using Infinium Human Methylation 850 BeadChip array. Adeno-associated...
The study aimed to explore the efficacy and potential mechanisms of a naturally aromatic cyanogenic compound-amygdalin (AMY) in treating glucocorticoid (GC)-associated necrosis femoral head (GANFH). We demonstrated that GC exacerbates oxidative stress (OS) microenvironment via promoting nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) expression human, rat, mesenchymal stem cells (MSCs) samples, thus generating excessive ROS, leading increased apoptosis unbalanced osteolipogenic...
Abstract Inner speech is a silent verbal experience and plays central roles in human consciousness cognition. Despite impressive studies over the past decades, neural mechanisms of inner remain largely unknown. In this study, we adopted an ecological paradigm called situationally simulated speech. Unlike mere imaging words, involves dynamic integration contextual background, episodic semantic memories, external events into coherent structure. We conducted activation network analyses on fMRI...
Abstract Purpose Previous studies have shown that DNA methyltransferase 3b (Dnmt3b) is the only Dnmt responsive to fracture repair and Dnmt3b ablation in Prx1-positive stem cells chondrocyte both delayed repair. Our study aims explore influence of Gli1-positive healing mice underlying mechanism. Methods We generated Gli1-CreERT2; Dnmt3bflox/flox (Dnmt3b Gli1ER ) operated tibia fracture. Fracture callus tissues control were collected analyzed by X-ray, micro-CT, biomechanical testing,...