A5080809194- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- CRISPR and Genetic Engineering
- Lymphoma Diagnosis and Treatment
- Radiation Dose and Imaging
- Medical Imaging Techniques and Applications
- Chronic Lymphocytic Leukemia Research
- RNA and protein synthesis mechanisms
- Muscle Physiology and Disorders
- Radiation Detection and Scintillator Technologies
- Radiation Effects and Dosimetry
- RNA regulation and disease
- Advanced biosensing and bioanalysis techniques
- Spine and Intervertebral Disc Pathology
- Acute Lymphoblastic Leukemia research
- Digital Radiography and Breast Imaging
- Traditional Chinese Medicine Analysis
- Advanced X-ray and CT Imaging
- Advances in Oncology and Radiotherapy
- Microscopic Colitis
- Neuroendocrine regulation and behavior
- Colorectal Cancer Treatments and Studies
- Traditional Chinese Medicine Studies
- Inflammatory Bowel Disease
- Stress Responses and Cortisol
Tianjin Normal University
2019-2025
Bristol-Myers Squibb (United States)
2020-2024
Zhejiang Chinese Medical University
2021-2024
First Hospital of Jilin University
2023-2024
Jilin University
2023-2024
Shenzhen Technology University
2024
Oregon Health & Science University
2010-2023
University of Toronto
2023
Huaian First People’s Hospital
2021-2022
Nanjing Medical University
2021-2022
Background: Adalimumab, a fully human tumor necrosis factor (TNF) antagonist, is an effective treatment for patients with Crohn disease who are naive to the chimeric TNF infliximab. No anti-TNF agent has been evaluated prospectively in had responded another and then lost that response or were intolerant of agent. Objective: To determine whether adalimumab induces remissions more frequently than placebo adult have symptoms despite infliximab therapy cannot take because adverse events. Design:...
Romidepsin, a histone deacetylase inhibitor, has demonstrated activity in relapsed or refractory peripheral T-cell lymphoma (PTCL) as single agent. Cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) therapy is widely used first-line treatment of PTCL; however, it limited efficacy. Results from phase Ib II study showed the feasibility combining romidepsin with CHOP (Ro-CHOP).This randomized III Ro-CHOP versus adult patients previously untreated PTCL. All received 3-week cycles...
JCO
Prime editing enables precise and efficient genome editing, but its efficacy is hindered by pegRNA's 3' extension, forming secondary structures due to high complementarity with the protospacer. The continuous presence of prime system also leads unintended indel formation, raising safety concerns for therapeutic applications. To address these challenges, we develop a mismatched pegRNA (mpegRNA) strategy that introduces bases into protospacer, reducing structure preventing sustained activity....
Adalimumab, a fully human anti-tumor necrosis factor (anti-TNF) monoclonal antibody, is approved for the treatment of Crohn's disease (CD) in adults. We evaluated overall safety profile adalimumab global clinical trials patients with CD. Patients who participated these trials, which included randomized induction and maintenance Phase IIIb open-label extension studies, had moderately to severely active CD were at regular intervals.Rates adverse events interest assessed per 100-patient-years...
Weaning of piglets is accompanied by intestinal inflammation, impaired barrier function, and microflora disorder. Regulating structure can directly or indirectly affect health host growth development. However, whether dietary fiber (DF) affects the inflammatory response function affecting its metabolites unclear. In this study, we investigated role in relieving immune stress maintaining homeostasis using with lipopolysaccharide (LPS)-induced injury as a model. DF improved morphology...
Base editing technology is an ideal solution for treating pathogenic single-nucleotide variations (SNVs). No gene therapy has yet been approved eye diseases, such as retinitis pigmentosa (RP). Here, we show, in the rd10 mouse model, which carries SNV identified RP-causing mutation human patients, that subretinal delivery of optimized dual adeno-associated virus system containing adenine base editor corrects neuroretina with up to 49% efficiency. Light microscopy showed a thick and robust...
Abstract Prime editing is a versatile gene tool that enables precise sequence changes of all types in the genome, but its application rather limited by efficiency. Here, we first apply Suntag system to recruit transcription factor P65 and enhance desired outcomes prime system. Next, MS2 hairpins are used MS2-fused confirmed recruitment protein could effectively improve efficiency both PE3 PE5 systems. Moreover, this suggests increased most likely associated with induction chromatin...
Abstract CRISPR base editing techniques tend to edit multiple bases in the targeted region, which is a limitation for precisely reverting disease-associated single-nucleotide polymorphisms (SNPs). We designed an imperfect gRNA (igRNA) methodology, utilized with one or more that were not complementary target locus direct toward generation of single-base edited product. Base experiments illustrated igRNA CBEs greatly increased fraction relative normal efficiencies. Similar results obtained...
The regenerative capacity of muscle dramatically decreases with age because old stem cells fail to proliferate in response tissue damage. Here, we uncover key age-specific differences underlying this proliferative decline: namely, the genetic loci cyclin/cyclin-dependent kinase (CDK) inhibitors (CDKIs) p21 and p16 are more epigenetically silenced young cells, as compared old, both quiescent those responding injury. Interestingly, phosphorylated ERK (pERK) induced these by ectopic FGF2 is...
Abstract C-to-G base editors have been successfully constructed recently, but limited work has done on concurrent and A-to-G editing. In addition, there is also data how chromatin-associated factors affect the Here, we test a series of factors, chromosomal protein HMGN1 was found to enhance efficiency both By fusing HMGN1, GBE ABE Cas9, develop CRISPR-based dual-function editor (GGBE) which capable converting simultaneous A C G conversion with substantial editing efficiency. Accordingly,...
Summary Transformed lymphoma (TL) represents a heterogeneous group of lymphomas with an aggressive course and poor prognosis. We assessed the clinical benefit single‐agent lenalidomide based on histological origin, including transformed follicular (tFL) chronic lymphocytic leukaemia/small (tCLL/SLL). Our analysis included 33 patients TL. Patients received at median dose 25 mg/d. The overall response rate (ORR) was 46%, duration 12·8 months after follow‐up 5·6 months. Median progression‐free...
Summary Patients with aggressive non‐ H odgkin lymphoma ( NHL ) who relapse after autologous stem cell transplantation ASCT have a poor prognosis. Additional therapy is often poorly tolerated, and new treatment modalities are needed. This efficacy safety study was retrospective analysis of two phase II trials ‐002 ‐003) that studied single‐agent lenalidomide in patients relapsed/refractory prior n = 87) compared no 179). The overall response rate the group 39% [14% complete CR )], including...