A5103078730- Hippo pathway signaling and YAP/TAZ
- Cancer, Hypoxia, and Metabolism
- Inflammatory mediators and NSAID effects
- NF-κB Signaling Pathways
- Cancer, Lipids, and Metabolism
- Paraquat toxicity studies and treatments
- Peptidase Inhibition and Analysis
- Immune Response and Inflammation
- Immune cells in cancer
- PARP inhibition in cancer therapy
- Protein Degradation and Inhibitors
ShanghaiTech University
2018-2024
Chi Mei Medical Center
2005
Hyperactivation of YAP has been commonly associated with tumorigenesis, and emerging evidence hints at multilayered Hippo-independent regulations YAP. In this study, we identified a new MST4-YAP axis, which acts as noncanonical Hippo signaling pathway that limits stress-induced activation. MST4 kinase directly phosphorylated Thr83 to block its binding importin α, therefore leading cytoplasmic retention inactivation. Due consequential interplay between MST4-mediated phospho-Thr83 the...
Metastasis is the leading cause of high ovarian-cancer-related mortality worldwide. Three major processes constitute whole metastatic cascade: invasion, intravasation, and extravasation. Tumor cells often reprogram their metabolism to gain advantages in proliferation survival. However, whether how those metabolic alterations contribute invasiveness tumor has yet be fully understood. Here we performed a genome-wide CRISPR-Cas9 screening identify genes participating cell dissemination revealed...
ISEE-38 Introduction: An animal study in rats was conducted to evaluate the efficacy of N-acetylcysteine (NAC) paraquat intoxication and associated oxidative stress. The effectiveness treatment measured by change mortality rates markers stress, including glutathione, malondialdehyde superoxide anion production. Methods: different dosages paraquat-intoxicated were compared with those on NAC (100mg/kg × 4) after exposure. For stress study, total glutathione concentrations tissues a modified...