A5073520752- Immune Cell Function and Interaction
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Endoplasmic Reticulum Stress and Disease
- Cancer Immunotherapy and Biomarkers
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2023
High CD8+ T cell infiltration in colorectal cancer (CRC) should suggest a favorable prognosis and satisfactory response to immunotherapy; however, the vast majority of patients with CRC do not benefit from immunotherapy due poor infiltration. Therefore, better understanding mechanisms for exclusion tumors is needed. Tribbles homolog 3 (TRIB3) has been implicated as an oncoprotein, but its role regulating antitumor immune responses defined. Here, we demonstrated that TRIB3 inhibits various...
Elimination of cancer stem cells (CSCs) and reinvigoration antitumor immunity remain unmet challenges for therapy. Tumor-associated macrophages (TAMs) constitute the prominant population immune in tumor tissues, contributing to formation CSC niches a suppressive microenvironment. Here, we report that high expression inhibitor differentiation 1 (ID1) TAMs correlates with poor outcome patients colorectal (CRC). ID1 expressing maintain stemness impede CD8+ T cell infiltration. Mechanistically,...