A5003365784- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Digestive system and related health
- Reproductive biology and impacts on aquatic species
- RNA Research and Splicing
- Cancer-related Molecular Pathways
- Eicosanoids and Hypertension Pharmacology
- Circular RNAs in diseases
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Hormonal Regulation and Hypertension
- Molecular Biology Techniques and Applications
- Neuroscience of respiration and sleep
- Fish Biology and Ecology Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Medicinal Plant Pharmacodynamics Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Aquaculture Nutrition and Growth
- HER2/EGFR in Cancer Research
- Hippo pathway signaling and YAP/TAZ
- Pharmacological Effects and Toxicity Studies
- Sodium Intake and Health
- Music Therapy and Health
Ocean University of China
2013-2024
Shandong University
2018-2023
Shanghai Jiao Tong University
2021
Suzhou Municipal Hospital
2012-2021
Shanghai First People's Hospital
2021
Xi'an Jiaotong University
2017-2021
Nanjing Medical University
2013-2020
Shaanxi Provincial People's Hospital
2015-2019
Shanxi Medical University
2015-2019
Hebei Medical University
2018
Abstract Pyroptosis, a form of programmed cell death (PCD), has garnered increasing attention as it relates to innate immunity and diseases. However, the involvement pyroptosis in mechanism by which lobaplatin acts against colorectal cancer (CRC) is unclear. Our study revealed that treatment with reduced viability HT-29 HCT116 cells dose-dependent manner. Morphologically, treated exhibited microscopic features swelling large bubbles emerging from plasma membrane, transmission electron...
STAT3 is constitutively activated in many malignant tumor types and plays an important role multiple aspects of cancer aggressiveness. In this study, we found that estrogen-related receptor α (ERR-α) correlating with was highly expressed triple-negative breast (TNBC) cell lines tissues, which associated both the pathologic stage prognosis patients TNBC. vitro studies showed ERR-α promoted TNBC migration invasion, regulated by STAT3. Phosphorylated (p-STAT3, Tyr 705) could bind to promotor...
Pulmonary fibrosis (PF) is the pathological structure of incurable fibroproliferative lung diseases that are attributed to repeated injury-caused failure alveolar regeneration (LAR). Here, we report repetitive damage results in a progressive accumulation transcriptional repressor SLUG epithelial type II cells (AEC2s). The abnormal increased inhibits AEC2s from self-renewal and differentiation into I (AEC1s). We found elevated represses expression phosphate transporter SLC34A2 AEC2s, which...
MicroRNA (miR)‑181a is a member of the miR‑181 family that serves key role in pathogenesis various cancer types. The present study aimed to investigate interaction between miR‑181a and Ras association domain protein1 isoform A (RASSF1A), their roles gastric carcinogenesis. RASSF1A was assessed cell lines tissues. direct binding identified using luciferase reporting gene system. effects on growth, cycle apoptosis were with Cell Counting Kit‑8 assay flow cytometry. division 25A (CDC25A),...
Increasing evidence has demonstrated that long non‑coding (lnc) RNA is aberrantly expressed in numerous types of cancer. Colorectal cancer a common malignancy; however, the role and mechanism underlying influence lncRNA‑colon associated transcript 1 (CCAT1) colorectal yet to be elucidated. The present study revealed CCAT1 highly tissues. Bioinformatics analysis dual‑luciferase reporter gene assay indicated microRNA (miR)‑218 had complementary binding sites. Furthermore, reverse...
Oxidative stress plays an important role in the pathogenesis of hypertension. Oligomeric proantho cyanidins (OPC) is main polyphenol presents grape seed and known for its potent antioxidant anti-inflammatory properties. In present study, we hypothesize that OPC can attenuate oxidative paraventricular nucleus hypothalamus (PVN), ameliorate neurotransmitter imbalance, decrease blood pressure sympathetic activity renovascular hypertensive rats. After induction hypertension by two-kidney...
In some vertebrates and invertebrates, semen release factors affecting female physiology behavior. Here, we report that delivered to females is potentially beneficial for promoting oocyte development in a viviparous teleost, Sebastes schlegelii. 88% of mated ovaries develop normally give birth larval fish, whereas 61% non-mated are arrested the previtellogenic stage. Semen's significant role (p < 0.0001) may involve remodeling follicular cells regulating expression extracellular matrix,...
Loss of caudal type homeobox 2 (CDX2) is associated with the development human colorectal cancer, while telomerase reverse transcriptase (hTERT) frequently occurs in variety cancers. We investigated effects restoration CDX2 expression using a hypoxia-inducible hTERT promoter-driven vector (pLVX-5HRE-hTERTp-CDX2-3FLAG) on colon cancer cell viability, cycle distribution, apoptosis, colony formation, invasion ability and xenograft tumor growth nude mice. overexpression significantly inhibited...
Pellino-1 (PELI1) is an E3 ubiquitin ligase acting as a key regulator for the inflammation and autoimmunity via ubiquitination of substrate proteins. There increasing evidence to support that PELI1 functions oncoprotein in tumorigenesis metastasis. However, molecular mechanism underlying high expression oncogenic roles cancers remains limited. Herein, we revealed novel regulation by which EGFR cooperate promote breast cancer positively correlated with cancers, its activation led...
Ivalin, an eudesmane-type sesquiterpene compound, was isolated from the Chinese herb Carpesium divaricatum in our chemistry group. In this study, we investigated anti-migration and anti-invasion activities underlying mechanisms of Ivalin breast cancer cells vitro. Cell viability evaluated using MTT assay, Western blotting used to determine expression E-cadherin, N-cadherin, vimentin ZEB1, mRNA levels were analyzed by qPCR. The effects measured wound-healing Transwell assays. connection,...