A5016971214- Laser-Matter Interactions and Applications
- Advanced Fiber Laser Technologies
- Spectroscopy and Quantum Chemical Studies
- Terahertz technology and applications
- Extracellular vesicles in disease
- Mass Spectrometry Techniques and Applications
- Autophagy in Disease and Therapy
- Laser Design and Applications
- Gyrotron and Vacuum Electronics Research
- bioluminescence and chemiluminescence research
- Advanced Glycation End Products research
- Sesquiterpenes and Asteraceae Studies
- Biochemical effects in animals
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Phytochemicals and Antioxidant Activities
- Cholinesterase and Neurodegenerative Diseases
- Spectroscopy Techniques in Biomedical and Chemical Research
- Nephrotoxicity and Medicinal Plants
- Phytochemistry and Biological Activities
- Erythropoietin and Anemia Treatment
- Renal Diseases and Glomerulopathies
- Atomic and Molecular Physics
- Endoplasmic Reticulum Stress and Disease
- Chronic Kidney Disease and Diabetes
- Immunotherapy and Immune Responses
University of Nebraska–Lincoln
2017-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2019
Central South University
2018
Shandong Agricultural University
2016
Chinese Academy of Sciences
2010-2014
Shanghai Institute of Materia Medica
2014
Institute of Physics
2010-2012
Impaired macroautophagy/autophagy is involved in the pathogenesis of hepatic fibrosis. However, how aberrant autophagy promotes fibrosis far from understood. Here, we aimed to define a previously unrevealed pro-fibrotic mechanism for stress protein TRIB3 (tribbles pseudokinase 3)-mediated dysfunction. Human fibrotic liver tissues were obtained patients with cirrhosis who underwent an open surgical repair process. The functional implications evaluated mouse models induced by bile duct...
We present a theoretical analysis showing how chirp can be used to sculpt two-color driving laser field waveforms in order enhance high-order harmonic generation (HHG) and/or extend HHG cutoff energies. Specifically, we consider composed of two ultrashort pulses having different carrier frequencies each which linear is introduced. Two pairs the component are considered: ($\ensuremath{\omega}, 2\ensuremath{\omega}$) and 3\ensuremath{\omega}$). Our results show changing signs chirps leads...
Use of time delays in high-order-harmonic generation (HHG) driven by intense two-color, few-cycle pulses is investigated order to determine means optimizing HHG intensities and plateau cutoff energies. Based upon numerical solutions the time-dependent Schr\"odinger equation for H atom as well analytical analyses, we show that introducing a delay between can result an enhancement intensity spectrum magnitude (or more) at cost reduction energy. Results both positive negative various pulse...
Intense ultrafast pulses cause dissociative ionization and shaping the may allow control of both electronic nuclear dynamics that determine ion yields. We report on a combined experimental theoretical effort to how shaped laser affect tunnel ionization, process precedes many strong-field phenomena. carried out experiments Ar, ${\mathrm{N}}_{2}$, ${\mathrm{H}}_{2}\mathrm{O}$, ${\mathrm{O}}_{2}$ using phase-step function amplitude $\frac{3}{4}\ensuremath{\pi}$ is scanned across spectrum pulse....
Abstract In the present investigation, a series of dimethoxy or methylenedioxy substituted‐cinnamamide derivatives containing tertiary amine moiety ( N. N‐Dimethyl, N, N‐diethyl, Pyrrolidine, Piperidine, Morpholine ) were synthesized and evaluated for cholinesterase inhibition blood‐brain barrier (BBB) permeability. Although their chemical structures are similar, biological activities exhibit diversity. The results showed that all compounds except those morpholine group exhibited moderate to...
We investigate theoretically how the duration of an isolated attosecond pulse (IAP) can be minimized by carefully selecting frequencies high-order harmonic generation (HHG) spectra produced ultrashort driving laser pulses. Based on numerical calculations HHG solving time-dependent Schr\"odinger equation for a single H atom, we provide three strategies generating shorter IAPs. First, when high-frequency region plateau is selected one should use below cutoff. Second, wide low-frequency produce...
We study the carrier-envelope-phase (CEP) effect of a few-cycle laser pulse on bound-bound transitions in helium high-frequency region. Specifically, for one-photon transition from $1{\phantom{\rule{0.16em}{0ex}}}^{1}\phantom{\rule{-0.16em}{0ex}}S$ to $2{\phantom{\rule{0.16em}{0ex}}}^{1}\phantom{\rule{-0.16em}{0ex}}P$ state, CEP increases as frequency increases; while two-photon $3{\phantom{\rule{0.16em}{0ex}}}^{1}\phantom{\rule{-0.16em}{0ex}}D$ shows peak at that is almost equal energy...
We investigate numerically with Hylleraas coordinates the frequency dependence of carrier-envelope phase (CEP) effect on bound-bound transitions helium induced by an ultrashort laser pulse a few cycles. find that CEP is very sensitive to carrier pulse, occurring regularly even at far-off-resonance frequencies. By analyzing two-level model, we can be attributed quantum interference between neighboring multiphoton transition pathways, which made possible broadened spectrum pulse. A general...
Macrocyclic glycosides with unique 22-membered dimeric lactone skeleton, are rare occurring natural products. There only ten compounds reported so far. Herein we the isolation and characterisation of five macrocyclic from Schoenoplectus tabernaemontani, including three new (Schoenopolide A-C, 1–3) two known ones, Berchemolide (4) Clemoarmanoside B (5). Their structures were established on basis extensive analysis spectroscopic data. In addition, anti-oxidative activity against H2O2-induced...
Abstract In the present study, a series of derivatives and analogs daidzein were designed synthesized to investigate cholinesterase inhibition blood–brain barrier permeability. The enzyme assay showed that most compounds containing tertiary amine group exhibit moderate inhibition, 7‐hydroxychromone (absence B ring scaffold) only have weaker bioactivity, while those without no bioactivity. Among them compound 15a (4’‐ N,N ‐dimethylaminoethoxy‐7‐methoxyisoflavone) appeared best inhibitory...
Reaching an ever shorter duration of isolated attosecond pulses (IAPs) is ongoing mission in science. Wide usage long-wavelength driving lasers has greatly broadened bandwidths for generating IAPs. We propose a strategy to further exploit the ability laser producing short introduce scaling relationship between IAP and trajectory parameter that associated with classical cutoff high-order harmonic generation (HHG) gases. This can facilitate shortening by shaping waveform. demonstrate...
Effects of exogenous abscisic acid (ABA) on antioxidant enzymes activities and endosperm cell division two wheat (Triticum aestivum L.) cultivars were investigated. Results showed that the superoxide dismutase (SOD), peroxidase (POD), catalase (CAT) activity in flag leaves both is elevated by application ABA it correlated with less membrane damage: lower malondialdehyde (MDA). Exogenous significantly increased number rate, finally grain weight. Although treatment decreased endogenous zeatin...
In recent years, chronic kidney disease (CKD) has emerged as an increasingly significant issue due to the growing prevalence and high treatment costs. While recorded positive diuretic effect of Schoenoplectus tabernaemontani, there is a lack reports on its efficacy in treating CKD. The pharmacological effects mechanisms tabernaemontani rhizomes aqueous extracts (STE) CKD were investigated by inducing rodent model via injection Adriamycin (ADR; 7.5 mg/kg) into tail vein Wistar rats. summary,...