A5100409500- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Helicobacter pylori-related gastroenterology studies
- Galectins and Cancer Biology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal disorders and treatments
- Cytokine Signaling Pathways and Interactions
- Gastric Cancer Management and Outcomes
- Eosinophilic Esophagitis
- Immune Response and Inflammation
- Pediatric Hepatobiliary Diseases and Treatments
- Molecular Biology Techniques and Applications
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Appendicitis Diagnosis and Management
- Liver Disease Diagnosis and Treatment
- Aquaculture disease management and microbiota
- Lipid metabolism and disorders
- Alcoholism and Thiamine Deficiency
- Testicular diseases and treatments
- Autoimmune and Inflammatory Disorders Research
- Congenital heart defects research
- Ferroptosis and cancer prognosis
- Hydrogen's biological and therapeutic effects
- IL-33, ST2, and ILC Pathways
Hangzhou First People's Hospital
2022-2025
Westlake University
2024-2025
Integrated Chinese Medicine (China)
2023-2025
Zhejiang Cancer Hospital
2025
Hangzhou Academy of Agricultural Sciences
2025
Zhejiang University
2022-2024
Guangxi Academy of Fishery Sciences
2024
Albert Einstein College of Medicine
2019-2024
Montefiore Medical Center
2024
Shandong Provincial Hospital
2023
To evaluate alterations of the intestinal bacteria and its associations with inflammation in acute pancreatitis (AP).A multihospital prospective clinical study was conducted, a total 108 participants were enrolled our study, including 44 severe AP (SAP), 32 mild (MAP), healthy volunteers. The structure microbiota, 10 predominant bacteria, plasma endotoxin, serum cytokines investigated by polymerase chain reaction-denaturing gradient gel electrophoresis, real-time quantitative reaction,...
Objective The Lactate-to-Albumin Ratio (LAR) has been applied as a new predictor in sepsis, heart failure, and acute respiratory failure. However, the role of LAR predicting all-cause mortality patients with pancreatitis not evaluated. Therefore, this study aimed to elucidate correlation between 28-d Acute Pancreatitis (AP). Methods This is retrospective cohort data from MIMIC-IV (v1.0) database. We included adult who were admitted intensive care unit study. primary outcome was evaluate...
Abstract Abnormal activation of ferroptosis worsens the severity acute pancreatitis and intensifies inflammatory response organ damage, but detailed underlying mechanisms are unknown. Compared with other types pancreatitis, hyperlipidemic (HLAP) is more likely to progress necrotizing possibly due peripancreatic lipolysis production unsaturated fatty acids. Moreover, high levels acids undergo lipid peroxidation trigger further exacerbate inflammation worsen HLAP. This paper focuses on...
Purpose To evaluate the usefulness of scrotal and transrectal ultrasonography (US) in differential diagnosis azoospermia etiologic classification obstructive azoospermia. Materials Methods This study was approved by institutional ethics committee, all patients provided written informed consent. Between April 2006 November 2008, 100 infertile men (mean age, 32 years; range, 22–51 years) with were evaluated at US, an emphasis on abnormal US findings seminal tract measurement testicular volume....
Bacteria have different characteristics in stimulation of human neutrophils to produce reactive oxygen species (ROS) and chemokines. This study examined the ability Helicobacter pylori induce production ROS chemokines by neutrophils.H. strains (1.5 x 108 CFU/ml) were cocultured with 5 104 isolated from healthy subjects. Samples incubated serum or without IgG antibodies H. pylori. was measured using luminol-dependent chemiluminescence (LmCL), concentrations (IL-8, RANTES, MIP-1alpha MCP-1)...
Certain lower organisms achieve organ regeneration by reverting differentiated cells into tissue-specific progenitors that re-enter embryonic programs. During muscle in the urodele amphibian, postmitotic multinucleated skeletal myofibers transform mononucleated proliferating upon injury, and a transcription factor-msx1 plays role their reprograming. Whether this powerful strategy can be leveraged mammals remains unknown, as it has not been demonstrated dedifferentiated progenitor arising...
Introduction Acute pancreatitis (AP) is an inflammatory disease with very poor outcomes. However, the order of induction and coordinated interactions systemic response syndrome (SIRS) compensatory anti-inflammatory (CARS) potential mechanisms in AP are still unclear. Methods An integrative analysis was performed based on transcripts blood from patients different severity levels (GSE194331), as well impaired lung (GSE151572), liver (GSE151927) pancreas (GSE65146) samples experimental model to...
Bacterial translocation from the gut to mesenteric lymph nodes and other extraintestinal sites is an important source of infection in acute pancreatitis. Impaired host immunity known promote bacterial translocation. Interleukin-6 (IL-6) a multifunctional cytokine that regulates immune response, phase reaction, hematopoiesis.Twenty-four mongrel dogs (18-29 kg) were studied four equal groups. In Groups I II, pancreatitis was induced by direct pressure injection 4% taurocholate trypsin into...
Cholangiocarcinoma is a rare tumor accounting for less than 2% of all human malignancies.1 The hilar cholangiocarcinoma (HCC) was first described by Klatskin, and thus called Klatskin tumor. HCC the most common bile tract tumor, 40% to 60% these tumors, which affect approximately 7500 Americans each year.2–4 clear cell variant occurs at variable frequencies among large series HCC. vacuolated appearance cells due cytoplasmic accumulation amount glycogen or lipids dissolved routine...
Bacterial translocation (BT) from the gastrointestinal tract to mesenteric lymph nodes (MLNs) and other extra intestinal organs is an important source of infection in acute pancreatitis (AP). Lexipafant (BB-882) a potent platelet-activating factor receptor antagonist that has anti-inflammatory effect. To examine whether BB-882 could affect BT necrotizing pancreatitis, 48 male Sprague Dawley rats (250–350 g) were studied. AP was induced Group I II by pressure injection 3% taurocholate trypsin...
Xinfeng Xu, Jun Wang, Qiang Liu, Wei Wen, Hai Zhang, Quan Zhu, Yijiang Chen, Liang Chen
Many gallbladder adenocarcinomas (ACs) are detected incidentally in routine cholecystectomy specimens, yet sampling practices vary when intestinal metaplasia (IM) or dysplasia found via sampling. Our practice has been to submit 5 additional sections IM is found, but cases with entirely submitted. We sought determine an appropriate protocol encountering these findings. retrospectively identified specimens features over a 26-month period, yielding 48 of 4059 (1%) cases. Four pathologists...
Abstract: Pancreatic hepatoid carcinoma (HC) is a heterogeneous tumor with high degree of malignancy and poor prognosis, which display cytological and/or structural features focal hepatocellular (HCC). For the low incidence atypical clinical symptoms, it possible to be diagnosed as pancreatic cancer before operation, mainly depending on pathological examination. To best our knowledge, surgery combined radiotherapy chemotherapy common treatment HC. However, curative effect prognosis poor. We...