A5031305202- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Practices and Patient Outcomes
- Medication Adherence and Compliance
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Blood Pressure and Hypertension Studies
- Obesity, Physical Activity, Diet
- Lipoproteins and Cardiovascular Health
- Health disparities and outcomes
- Heart Failure Treatment and Management
- Advanced Causal Inference Techniques
- Nutritional Studies and Diet
- Atrial Fibrillation Management and Outcomes
- Dementia and Cognitive Impairment Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Asthma and respiratory diseases
- Peripheral Artery Disease Management
- Chronic Disease Management Strategies
- Genetic Associations and Epidemiology
- Hormonal Regulation and Hypertension
- Healthcare Policy and Management
- Statistical Methods in Clinical Trials
- Coronary Interventions and Diagnostics
- Diet and metabolism studies
- Diabetes Management and Education
- Machine Learning in Healthcare
Kaiser Permanente
2013-2023
Parker Hannifin (United States)
2020-2021
Amgen (United States)
2007-2020
Kaiser Permanente Center for Health Research
2013-2018
Japan Society
2018
Bechtel (United States)
2018
Colorado Permanente Medical Group
2018
Center for Surveillance, Epidemiology, and Laboratory Services
2018
Centers for Disease Control and Prevention
2018
Outcomes Research Consortium
2013-2016
Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates serum LDL cholesterol (LDL-C) by interacting with the receptor (LDLR) and is an attractive therapeutic target for LDL-C lowering. We have generated a neutralizing anti-PCSK9 antibody, mAb1, that binds to epitope on PCSK9 adjacent region required LDLR interaction. In vitro, mAb1 inhibits binding attenuates PCSK9-mediated reduction in protein levels, thereby increasing uptake. A combination of statin increases levels HepG2 cells...
OBJECTIVES: The purpose of this study was to evaluate the contribution executive cognitive functions self‐reported and observed performance activities daily living instrumental living. DESIGN: These data were collected as part a cross‐sectional survey community‐dwelling older persons, using statistical sampling, in two‐county area southern Colorado. SETTING: Participants interviewed administered measures general cognition, depression, functioning, self‐care activities, either their homes or...
OBJECTIVES: This study investigated whether objective health indicators explained lower self-rated among Hispanics compared with non-Hispanic Whites. It also considered socioeconomic and cultural explanations. METHODS: Health ratings of 429 583 Whites aged 20 through 74 were analyzed logistic regression. RESULTS: Illness found to be strongly correlated in both ethnic groups, but after such markers controlled for, remained 3.6 times more likely report fair or poor (95% confidence interval =...
Existing studies have examined the high prevalence of LBP along with treatment costs patients low back pain (LBP). Various factors been shown to be correlated or predictive chronic episodic including characteristics initial episode, pain, comorbid conditions, psychosocial issues, and opiate use. This study replicates extends earlier by examining association patient baseline comorbidities patterns healthcare service use cost.This is a retrospective analysis measures comorbidities, use, cost...
To evaluate the effectiveness of 1 and 2 doses 2003-2004 influenza vaccine in preventing medically attended influenza-like illness (ILI) among children 6 to 23 months 8 years age.Outpatient emergency department visits immunization records were used conduct a retrospective cohort study age. ILI pneumonia (P&I) outcomes defined on basis International Classification Diseases, Ninth Revision, codes. Influenza (VE) was calculated as (1 - hazard rate ratio) x 100.A total 29726 included analyses;...
OBJECTIVE To determine if dietary fat intake measured at a baseline exam in subjects with impaired glucose tolerance (IGT) predicted the subsequent development of non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS Based on an oral test (OGTT) (World Health Organization criteria), we identified 134 eligible IGT from geographically based sample no prior history diabetes. One to three years after exam, 123 (92%) had repeat OGTT. Diet was assessed by 24-h diet recall...
Background: Despite the importance of blood pressure (BP) control in secondary prevention, a significant proportion patients with coronary disease have uncontrolled BP.Methods: This retrospective cohort study (N = 10 447) evaluated impact medication nonadherence and therapy intensification on reaching target BP goals.Medication adherence was calculated as days covered for filled prescriptions antihypertensive medications.Therapy included dosage increase or number medications.The primary...
Individuals with dementia or mild cognitive impairment frequently have multiple chronic conditions (defined as ≥2 medical conditions) and take medications, increasing their risk for adverse outcomes. Deprescribing (reducing stopping medications which potential harms outweigh benefits) may decrease of
Most patients with asthma take fewer than half of prescribed doses controller medication. Interventions to improve adherence have typically been costly, impractical, and at best only minimally successful. To test a speech recognition (SR) intervention pediatric The Breathe Well study was 24-month pragmatic randomized clinical trial. conducted within Kaiser Permanente Colorado, large, group-model health maintenance organization. A total 1187 children aged 3 12 years persistent diagnosis...
<h3>Importance</h3> The clinical practice guidelines for heart failure recommend the use of validated risk models to estimate prognosis. Understanding how well identify individuals who will die in next year informs decision making advanced treatments and hospice. <h3>Objective</h3> To quantify calculated routine more than 50% 1-year mortality among ambulatory patients with subsequent year. <h3>Design, Setting, Participants</h3> Ambulatory adults from 3 integrated health systems were enrolled...
Patients have typically received health care through face-to-face encounters. However, expansion of electronic communication and records (EHRs) provide alternative means for patient physicians to interact. Electronic consultations may complement regular healthcare by providing "better, faster, cheaper" processes diagnosing, treating, monitoring conditions. Virtual consultation between a method streamlining care, potentially saving patients the time expense added visits. The purpose this...
Little is known about how different financial incentives between Medicare Advantage and fee-for-service (FFS) reimbursement structures influence use of cardiovascular procedures.To compare regional procedure rates FFS beneficiaries.Cross-sectional study beneficiaries older than 65 years 2003-2007 comparing coronary angiography, percutaneous intervention (PCI), artery bypass graft (CABG) surgery across 32 hospital referral regions in 12 states.Rates PCI, CABG surgery.We evaluated a total...
<h3>Importance</h3> Attempts to discontinue opioid therapy reduce the risk of overdose and adhere prescribing guidelines may lead patients be exposed variability in dosing. Such dose increase even if discontinuation is associated with a reduction risk. <h3>Objective</h3> To examine association between overdose. <h3>Design, Setting, Participants</h3> A nested case-control study was conducted large Colorado integrated health plan delivery system from January 1, 2006, through June 30, 2018....
LDL cholesterol (LDL-C) contributes to coronary heart disease. Proprotein convertase subtilisin/kexin type 9 (PCSK9) increases LDL-C by inhibiting clearance. The therapeutic potential for PCSK9 inhibitors is highlighted the fact that loss-of-function carriers exhibit 15–30% lower circulating and a disproportionately risk (47–88%) of experiencing cardiovascular event. Here, we utilized pcsk9−/− mice an anti-PCSK9 antibody study role receptor (LDLR) ApoE in PCSK9-mediated regulation plasma...
Objective To determine whether higher levels of physical activity would be associated with lower fasting insulin and C-peptide in a free-living nondiabetic population. Research Design Methods A cross-sectional study was conducted Hispanic non-Hispanic white population 442 men 489 women normal glucose tolerance (by World Health Organization criteria) two rural Colorado counties. Total assessed by 7-day recall from which metabolic equivalents were estimated. Relationships between while...
To investigate risk factors for distal symmetric (sensory) neuropathy among prevalent cases of non-insulin-dependent diabetes mellitus (NIDDM) in a population-based study southern Colorado.Prevalent was identified 77 277 people with NIDDM by standardized history and neurologic examination. Fifteen known or suspected were determined without knowledge status.Older age at examination, longer duration diabetes, higher glycohemoglobin percentage, lower fasting C-peptide, insulin use, presence...
The objective of this study was to determine the association between parental depression and pediatric health care use patterns.We selected all children who were 0 17 years age, enrolled in Kaiser Permanente Colorado during period July 1997 December 2002, linked at least 1 parent/subscriber for 6 months that period. Unexposed from a pool whose parents did not have diagnosis. Outcome measures derived child's payment files electronic medical charts included 5 categories use: well-child-care...
Treatment for symptomatic peripheral artery disease includes lower extremity bypass surgery (LEB) and endovascular interventions (PVIs); however, limited comparative effectiveness data exist between the 2 therapies. We assessed safety of LEB PVI in patients with claudication critical limb ischemia.
Background— Bleeding after hospital discharge from percutaneous coronary intervention (PCI) is associated with increased risk of subsequent myocardial infarction (MI) and death; however, the timing adverse events these bleeding poorly understood. Defining this relationship may help clinicians identify critical periods when patients are at highest risk. Methods Results— All undergoing PCI 2004 to 2007 who survived without a event were identified HMO Research Network-Stent (HMORN-Stent)...
OBJECTIVE To determine the incidence and risk factors for distal symmetric sensory neuropathy (DSN) in people with NIDDM. RESEARCH DESIGN AND METHODS Prospective follow-up was conducted from 1988 to 1992 on 231 free of DSN during baseline period 1984–1988 (mean follow-up, 4.7 years). Subjects incident (n = 66) were defined by any two three criteria: 1) bilateral paresthesia legs or feet; 2) decreased absent ankle reflexes; and/or 3) cold temperature discrimination feet. Of all 66 cases, 42...