A5085742422- Phytochemicals and Antioxidant Activities
- Acupuncture Treatment Research Studies
- Food Allergy and Anaphylaxis Research
- Microbial Inactivation Methods
- Cerebral Venous Sinus Thrombosis
- Diabetes Treatment and Management
- Liver Disease Diagnosis and Treatment
- Transgenic Plants and Applications
- Genetically Modified Organisms Research
- Microencapsulation and Drying Processes
- Monoclonal and Polyclonal Antibodies Research
- Infant Nutrition and Health
- Protein Hydrolysis and Bioactive Peptides
- Food composition and properties
- Receptor Mechanisms and Signaling
- Traditional Chinese Medicine Studies
- Proteins in Food Systems
- Microbial Metabolites in Food Biotechnology
- Infant Health and Development
- Hematological disorders and diagnostics
- Nuts composition and effects
- Meat and Animal Product Quality
- Healthcare and Venom Research
- Venous Thromboembolism Diagnosis and Management
- Polysaccharides Composition and Applications
Guangdong Pharmaceutical University
2024
Kunming Medical University
2024
University of Nebraska–Lincoln
2014-2022
Nanjing Medical University
2009-2018
Jiangsu Province Hospital
2009-2018
Cleveland Clinic
2013-2018
Amgen (United States)
2012-2017
Cleveland Clinic Lerner College of Medicine
2013-2015
Ocular Surface Center
2015
Nantong University
2013
Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates serum LDL cholesterol (LDL-C) by interacting with the receptor (LDLR) and is an attractive therapeutic target for LDL-C lowering. We have generated a neutralizing anti-PCSK9 antibody, mAb1, that binds to epitope on PCSK9 adjacent region required LDLR interaction. In vitro, mAb1 inhibits binding attenuates PCSK9-mediated reduction in protein levels, thereby increasing uptake. A combination of statin increases levels HepG2 cells...
In man, glucagon-like peptide-I-(7-37) [GLP-I-(7-37)] is the most potent endogenous insulin-stimulating hormone. Although GLP-I-(7-37)-stimulated insulin secretion from beta-cell associated with an increase in cAMP accumulation, little known about signal transduction pathways used by this peptide. Using a cDNA encoding high affinity rat GLP-I-(7-37) receptor [Kd = 4.1 nM for GLP-I-(7-37); Kd 1 microM GLP-I-(1-36) amide] expressed monkey kidney cell line (COS-7), we have demonstrated that not...
The Soybean (Glycine max) leghemoglobin c2 (LegHb) gene was introduced into Pichia pastoris yeast for sustainable production of a heme-carrying protein, organoleptic use in plant-based meat. potential allergenicity and toxicity LegHb 17 host-proteins each representing ≥1% total protein batches are evaluated by literature review, bioinformatics sequence comparisons to known allergens or toxins, vitro pepsin digestion.
Summary The in vitro digestive stability of phenolic compounds and the antioxidant capacity five kinds commonly consumed fruit juices daily diet, including apple juice ( AJ ), orange OJ grape GJ pomelo PJ ) kiwifruit KJ were studied. Following digestion, total TP content decreased to different extents by 35%, 25.3%, 23.5%, 22.2% 7.8% for , respectively. individual showed similar changes content, showing reductions naringenin‐trisaccharide epicatechin chlorogenic acid 43.74%, 27.59%, 47.11%...
Summary A natural colourant derived from purple‐fleshed sweet potato ( PFSP ) by ultrasound‐assisted solvent extraction was examined in terms of its anthocyanins and 6‐month storage stability under different conditions: avoid light at 25 AL 25) 37 °C 37) fluorescent FL 25). This mainly contained the following peonidin anthocyanins: 3‐p‐hydroxybenzoyl sophoroside‐5‐glucoside, 3‐feruloyl 3‐caffeoyl dicaffeoyl 3‐caffeoyl‐ p ‐hydroxybenzoyl sophoroside‐5‐glucoside caffeoyl‐feruloyl...
Glycosylation with pectin simultaneously improved the emulsifying properties of egg phosvitin and calcium binding capacity its phosphopeptides.
d-Psicose is a new-generation sugar substitute with low calorie count and can still offer the desirable sweetness. The objective of this study was to investigate antiobesity potential d-psicose possible mechanism using Wistar rats as animal model. animals were divided into five groups supplemented diets containing 5% different carbohydrates, such glucose, fructose, cellulose, d-psicose, control diet, for 4 weeks. After sacrifice, blood lipid profile, tissue morphology, related genes...
Insects are a potentially environmentally friendly alternative dietary protein source to supplement mammalian and fish sources, but potential allergenic risks concern. Consumption of insects may result in anaphylaxis has been implicated cross-reactivity with shellfish. Many proteins be involved cross-reactivity, including tropomyosin (TM). The uniformity TM among edible is unknown. Candidate for variability shellfish IgE investigated.Selected known related sources allergens extracted probed...
Soybean is recognized as a commonly allergenic food, but the identity of important allergens not well studied. Recently, some global regulatory agencies started requiring quantitative analysis individual allergens, including unproven part risk assessment for genetically engineered (GE) soybeans. We sought to identify soybean proteins that bind IgE from any 10 soybean-sensitized subjects. binding were identified by 2-DE immunoblots using sera four soy-allergic and plasma six soy-sensitized...
Aim: Hyperglycemia in hospitalized patients is associated with adverse outcomes; treatment of hyperglycemia the hospital improves outcomes. We investigated clinical outcomes and readmissions insulin continuation discontinuation post-discharge type 2 diabetes mellitus (T2DM) who initiated therapy during hospitalization. Materials Methods: This observational retrospective database analysis was performed using medical records obtained from a US coordinated health system. Patients T2DM, glycated...
Elucidating the role of secreted frizzled-related protein 5 (SFRP5) in metabolism and obesity has been complicated by contradictory findings when knockout mice were used to determine metabolic phenotypes. By overexpressing SFRP5 obese, prediabetic we consistently observed elevated hyperglycemia glucose intolerance, supporting as a negative regulator metabolism. Accordingly, Sfrp5 mRNA expression analysis both epididymal subcutaneous adipose depots indicated correlation with obesity. Thus,...
Banana Xanthomonas wilt (BXW) disease threatens banana production and food security throughout East Africa. Natural resistance is lacking among common cultivars. Genetically modified (GM) bananas resistant to BXW were developed by inserting the hypersensitive response-assisting protein (Hrap) or/and plant ferredoxin-like (Pflp) gene(s) from sweet pepper (Capsicum annuum). Several of these GM events showed 100% under field conditions in Uganda. The current study evaluated potential...