A5090127518- Treatment of Major Depression
- Magnesium Alloys: Properties and Applications
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Tissue Engineering and Regenerative Medicine
- Anesthesia and Neurotoxicity Research
- Bone Tissue Engineering Materials
- Aluminum Alloys Composites Properties
- Electrospun Nanofibers in Biomedical Applications
- Hormonal and reproductive studies
- Neuroscience and Neuropharmacology Research
- Estrogen and related hormone effects
- Corrosion Behavior and Inhibition
- Hydrogen's biological and therapeutic effects
University of Cincinnati Medical Center
2019-2023
University of Maryland, Baltimore
2021-2022
University of Cincinnati
2019-2020
North Carolina Agricultural and Technical State University
2019
Abstract A single subanesthetic infusion of ketamine can rapidly alleviate symptoms treatment-resistant major depression. Since repeated administration is required to sustain symptom remission, it important characterize the potential untoward effects prolonged exposure. While studies suggest that alter cognitive function, unclear what extent these are modulated by frequency or chronicity treatment. To test this, male and female adolescent (postnatal day [PD] 35) adult (PD 60) BALB/c mice...
There is an increasing interest in biodegradable metal implants made from magnesium (Mg), iron (Fe), zinc (Zn) and their alloys because they are well tolerated vivo have mechanical properties that approach those of non-degradable metals. In particular, Zn its show the potential to be next generation materials for medical implants. However, has not been as well-studied Mg, especially stent applications. Manufacturing stents by laser cutting become industry standard. Nevertheless, use this...
In vivo use of biodegradable magnesium (Mg) metal can be plagued by too rapid a degradation rate that removes support before physiological function is repaired. To advance the Mg biomedical implants, may need to adjusted. We previously demonstrated pure filaments used in nerve repair scaffold were compatible with regenerating peripheral tissues, reduced inflammation, and improved axonal numbers across short-but not long-gap sciatic nerves rats. determine if longer gaps would slower rate, we...
During the last decade, magnesium and its alloys have been extensively studied to develop a new generation of biodegradable medical implants. The fast degradation rate pure related in physiological environment poses significant challenges devices made these materials for biomedical applications. In this study we designed fabricated helical stents AZ31 alloy, explored their vitro corrosion behavior Dulbecco's Modified Eagle's Medium (DMEM). was significantly reduced by surface modifications...
Abstract In susceptible populations, stress is a major risk factor for the development of mental disorders, including depression. Estradiol, often considered female hormone, distributed in male brain via aromatization testosterone. The role estrogen receptors (ERs) susceptibility and depression not well understood. We found that absence ERβ associated with to mice activity ERβ-projecting neurons from basolateral amygdala nucleus accumbens reduced hypogonadal subjected stress, while...
Abstract Differential rodent responses to the sex of human experimenters could have far reaching consequences in preclinical studies. Here, we show that affects mouse behaviours and rapid-acting antidepressant ketamine its bioactive metabolite ( 2R,6R )-hydroxynorketamine. We found mice manifest aversion male odours, preference female increased susceptibility stress when handled by experimenters. This induced is mediated activation brain corticotropin-releasing factor (CRF) neurons...