A5065349385- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Down syndrome and intellectual disability research
- Hormonal and reproductive studies
- Neuroscience of respiration and sleep
- Genetics and Neurodevelopmental Disorders
- Treatment of Major Depression
- Neuroendocrine regulation and behavior
- Immune Response and Inflammation
- Advanced Neuroimaging Techniques and Applications
- Celiac Disease Research and Management
- Nitric Oxide and Endothelin Effects
- Complement system in diseases
- Neurogenesis and neuroplasticity mechanisms
- Gut microbiota and health
- Virology and Viral Diseases
- Hormonal Regulation and Hypertension
- Autism Spectrum Disorder Research
- Mosquito-borne diseases and control
- Microscopic Colitis
- Infectious Encephalopathies and Encephalitis
- Thermal Regulation in Medicine
University of Maryland, Baltimore
2015-2025
University of North Carolina at Chapel Hill
2024
VA Maryland Health Care System
2010-2022
National Center for Advancing Translational Sciences
2021
National Institute of Mental Health
2016-2021
National Institutes of Health
2016-2021
Institute on Aging
2021
National Institute on Aging
2021
Lieber Institute for Brain Development
2016
University at Buffalo, State University of New York
2013
<h3>Background:</h3> Neuroinflammatory processes are increasingly believed to participate in the pathophysiology of a number major psychiatric diseases, including depression. Immune activation stimulates conversion amino acid tryptophan kynurenine, leading formation neuroactive metabolites, such as quinolinic and kynurenic acid. These compounds affect glutamatergic neurotransmission, which plays prominent role depressive pathology. Increased degradation along kynurenine pathway (KP) has been...
Gait and balance disorders unresponsive to dopaminergic drugs in Parkinson9s disease (PD) are secondary lesions located outside the system. However, available animal models of PD fail display l-3,4-dihydroxyphenylalanine (DOPA)-responsive parkinsonism drug-resistant gait disorders, this lack appropriate model could account for deficit efficient treatments. Because pedunculopontine nucleus (PPN) plays an important role locomotion control, we conducted present study investigate consequences...
Diffusion Tensor magnetic resonance imaging and computational neuroanatomy are used to quantify postnatal developmental patterns of C57BL/6J mouse brain. Changes in neuronal organization myelination occurring as the brain matures into adulthood examined, a normative baseline is developed, against which transgenic mice may be compared genotype–phenotype studies. In early days, gray matter–based cortical hippocampal structures exhibit high water diffusion anisotropy, presumably reflecting...
The neurodevelopmental defects associated with ZIKV infections early in pregnancy are well documented, however the potential and long-term consequences milder late perinatal period less understood. To model these, we challenged 1 day old (P1) immunocompetent C57BL/6 mice ZIKV. animals developed a transient neurological syndrome including unsteady gait, kinetic tremors, severe ataxia seizures 10–15 days post-infection (dpi) but symptoms subsided after week, most survived. Despite apparent...
About one in three persons with a schizophrenia related disorder (SRD) have elevated anti-gliadin IgG antibodies (AGA). This AGA positive (AGA+) subgroup of SRD clinically has higher burden negative symptoms and are associated high functional impairments lack effective therapeutics. Alterations T cells been demonstrated SRD, we previously shown regulatory (Tregs) increased correlate fewer compared healthy controls. To further elucidate the role immune system AGA+ pathology, investigated...
Schizophrenia and related disorders (SRD) are characterized by positive negative symptoms, such as anhedonia avolition. There no current FDA approved treatments for which is a critical gap in our treatment of people with SRDs, since they major determinant functional impairment. An emerging literature suggests that SRDs have relationship immune function inflammation. Recently an SRD subgroup high inflammation elevated levels anti-gliadin antibodies (AGA) immunoglobulin G type (IgG) ha s been...
Abstract Objective Exposure to a number of drugs, chemicals, or environmental factors can cause parkinsonism. Epidemiologic evidence supports causal link between the consumption flour made from washed seeds plant Cycas micronesica by Chamorro population Guam and development amyotrophic lateral sclerosis/parkinsonism dementia complex. Methods We now report that cycad pellets Sprague‐Dawley male rats induces progressive Results Cycad‐fed displayed motor abnormalities after 2 3 months feeding...
Accumulating evidence supports a role of T cells in behavioral stress responsiveness. Our laboratory previously reported that lymphocyte deficient Rag2−/− mice on BALB/c background display resilience to maladaptive responses when compared with immune competent the predator odor exposure (POE) paradigm, while exhibiting similar behavior cued fear-conditioning (FC) paradigm. In present study, C57BL/6 were assessed same paradigms, as well additional tests anxiety and depressive-like behavior....
Angelman syndrome (AS) is a neurogenetic disorder caused by mutations or deletions in the maternally-inherited UBE3A allele, leading to loss of protein expression neurons. The paternally-inherited allele epigenetically silenced neurons during development noncoding transcript ( UBE3A-ATS ). absence neuronal results severe neurological symptoms, including speech and language impairments, intellectual disability, seizures. While no cure exists, therapies aiming restore function—either gene...
Accumulating evidence has shown that lymphocytes modulate behaviour and cognition by direct interactions with the central nervous system. Studies have reconstitution adoptive transfer of from wild type into immune-deficient mice restores a number neurobehavioural deficits observed in these models. Moreover, it been effects are mostly mediated T lymphocytes. thus far employed adult mice, but whether may also during development remains unknown. In this study, neonate lymphocyte-deficient...
Research has shown that inflammatory processes affect brain function and behavior through several neuroimmune pathways. However, high order functions affected by inflammation largely remain to be defined. Resting state functional connectivity of synchronized oscillatory activity is a valid approach understand network processing under different experimental conditions. In the present study multi-electrode EEG recording in awake, freely moving rats was used resting after administration...
Down Syndrome (DS), a genetic disease caused by triplication of chromosome 21, is characterized increased markers oxidative stress. In addition to cognitive defects, patients with DS also display hematologic disorders and incidence infections leukemia. Using the Ts65Dn mouse model DS, goal this study was examine hematopoietic stem lymphoid progenitor cell function in DS.Analysis populations showed that mice possessed fewer functional cells significantly decreased percentage bone marrow...