A5021520702- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Receptor Mechanisms and Signaling
- Advanced Fluorescence Microscopy Techniques
- Immune Response and Inflammation
- Neuropeptides and Animal Physiology
- Cardiac electrophysiology and arrhythmias
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Adipose Tissue and Metabolism
- Vascular Tumors and Angiosarcomas
- Genetic Neurodegenerative Diseases
- Analytical Chemistry and Sensors
- Immune cells in cancer
- Olfactory and Sensory Function Studies
- Acute Lymphoblastic Leukemia research
- Conducting polymers and applications
- Monoclonal and Polyclonal Antibodies Research
- Cytokine Signaling Pathways and Interactions
- Urological Disorders and Treatments
- Immunotherapy and Immune Responses
- Parasitic infections in humans and animals
- Chemical Synthesis and Analysis
BioCruces Health research Institute
2020-2024
Euskadiko Parke Teknologikoa
2016
Universidad de Navarra
2008-2009
RIKEN Center for Brain Science
2005-2008
University of the Basque Country
2000-2005
There is an actual need of advanced materials for the emerging field bioelectronics. One commonly used material conducting polymer poly(3,4‐ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) due to its general use in organic electronics. However, depending on application bioelectronics, PEDOT:PSS not fully biocompatible high acidity residual sulfonate protons PSS. In this paper, synthesis and biocompatibility properties new poly(3,4‐ethylenedioxythiophene):GlycosAminoGlycan...
Abstract Genetically encoded fluorescent Ca 2+ indicator proteins (FCIPs) are promising tools to study signaling in large assemblies of nerve cells. Currently, there few examples stable transgenic mouse lines that functionally express such sensors well‐defined neuronal cell populations. Here we report the generation and characterization mice expressing an FCIP under 5′ regulatory sequences Kv3.1 potassium channel promoter. In cerebellar cortex, expression was restricted granule We first...
Abstract During the last few years a variety of genetically encodable optical probes that monitor physiological parameters such as local pH, Ca 2+ , Cl – or transmembrane voltage have been developed. These sensors are based on variants green‐fluorescent protein (GFP) and can be synthesized by mammalian cells after transfection with cDNA. To use these sensor proteins in intact brain tissue, specific promoters needed drive expression at sufficiently high level distinct neuronal subpopulations....
Knowledge on the normal structure and molecular composition of peripheral nerves is essential to understand their pathophysiology select regeneration strategies after injury. However, precise lipid nerve still poorly known. Here, we present first study distribution individual lipids in mature sciatic rats by imaging mass spectrometry. Both positive negative ion modes were used detect, identify situ map 166 species mainly glycerophospholipids, sphingomyelins, sulfatides, diacyl...
Intronic single-nucleotide polymorphisms (SNPs) in the ANKRD55 gene are associated with risk for multiple sclerosis (MS) and rheumatoid arthritis by genome-wide association studies (GWAS). The alleles have been linked to higher expression levels of neighboring IL6ST (gp130) CD4+ T lymphocytes healthy controls. biological function ANKRD55, its role immune system, cellular sources other than remain uncharacterized. Here, we show that monocytes gain capacity express during differentiation...
The localization of metabotropic glutamate receptors groups II (mGluR2/3) and III (mGluR4a) the subunits 2 3 alfa-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) ionotropic (GluR2/3) was investigated with immunocytochemical methods in rat adrenal gland. MGluR2/3, mGluR4a GluR2/3 immunoreactivities were observed large-sized, centrally located type I medullary ganglion neurons. Furthermore, small-sized neurons identified by their immunoreactivity to brain nitric oxide synthase...
Abstract Introduction SNPs associated with genome-wide risk for multiple sclerosis (MS) modulate expression of ankyrin repeat domain protein 55 (ANKRD55). The function ANKRD55 is not well understood. A role in ciliar transport multiciliated cells has been reported. To gain deeper insight how may neuro-inflammatory parameters, we identified the interactomes from human neuroblastoma, astrocytic, microglial and monocytic cell lines. Methods Cell lines were transfected synthetic RNA conjunction...
Podocalyxin (PODXL), a cell surface sialomucin expressed in diverse types of normal and malignant cells, mediates cellular adhesion to extracellular matrix cell-to-cell interaction. A previous study reported the expression PODXL protein on monocytes undergoing macrophage differentiation, yet this molecule other antigen presenting cells (APCs) its function immune system still remain undetermined. In study, we report that is human monocyte-derived immature dendritic at both mRNA levels....