A5100457425- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neuropharmacology Research
- RNA modifications and cancer
- Pluripotent Stem Cells Research
- Nuclear Receptors and Signaling
- Advanced Antenna and Metasurface Technologies
- RNA Research and Splicing
- Antenna Design and Analysis
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Metamaterials and Metasurfaces Applications
- Receptor Mechanisms and Signaling
- Plant Reproductive Biology
- Neuroscience and Neural Engineering
- Memory and Neural Mechanisms
- Seed Germination and Physiology
- Plant tissue culture and regeneration
- CRISPR and Genetic Engineering
- Epigenetics and DNA Methylation
- Autism Spectrum Disorder Research
- Neurobiology and Insect Physiology Research
- Neurotransmitter Receptor Influence on Behavior
- Congenital heart defects research
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
Northwest University
2025
Weifang People's Hospital
2025
University of Wisconsin–Madison
2010-2024
Beijing Institute of Genomics
2021-2024
Chinese Academy of Sciences
2021-2024
Xiangya Hospital Central South University
2023-2024
Central South University
2023-2024
Cardiff University
2013-2024
Second Military Medical University
2024
Changhai Hospital
2024
Juvenile hormone (JH) plays crucial roles in many aspects of insect life. The Methoprene-tolerant ( Met ) gene product, a member the bHLH-PAS family transcriptional regulators, has been demonstrated to be key component JH signaling pathway. However, molecular function JH-induced signal transduction and regulation remains fully elucidated. Here we show that coactivator ecdysteroid receptor complex, FISC, acts as functional partner mediating expression. FISC appear use their PAS domains form...
Abstract We have generated embryonic stem (ES) cells and transgenic mice with green fluorescent protein (GFP) inserted into the Pitx3 locus via homologous recombination. In central nervous system, ‐directed GFP was visualized in dopaminergic (DA) neurons substantia nigra ventral tegmental area. Live primary DA can be isolated by fluorescence‐activated cell sorting from these mouse embryos. culture, –GFP is coexpressed a proportion of ES‐derived neurons. Furthermore, ES cell‐derived...
We present a new technique for designing microwave lenses with broadband, true-time-delay response types. The examined in this work are planar structures circular apertures populated numerous spatial time-delay units (TDUs). Each TDU is the unit cell of an appropriately designed lowpass frequency selective surface (FSS) that provides desired time delay over wide range. FSSs used paper either metallo-dielectric or all-dielectric type multi-layer structures. A FSS composed number capacitive...
In this letter, a new technique for designing tunable frequency selective surfaces (FSSs) with the second-order band-pass response is presented and experimentally verified. The applied to an FSS utilizing nonresonant, subwavelength, constituting unit cells. Frequency tuning achieved by adjusting location of liquid metal slug within capillary tubes embedded between FSS's metallic layers. A wideband flexible covering nearly entire X band tested in waveguide environment excellent agreement...
Pitx3 is a critical homeodomain transcription factor for the proper development and survival of mesodiencephalic dopaminergic (mdDA) neurons in mammals. Several variants this gene have been associated with human Parkinson's disease (PD), lack mice causes preferential loss substantia nigra pars compacta (SNc) mdDA that are most affected PD. It currently unclear how activity promotes SNc which factors act upstream downstream context. Here we show transient expression glial cell line-derived...
We examine the peak power handling capability of a class miniaturized-element frequency selective surfaces composed entirely non-resonant constituting elements. The effects various design parameters on these structures are investigated using electromagnetic simulations and methods for increasing their proposed. These used to high-power microwave (HPM) surface (FSS), which is expected be capable extremely high levels. capabilities devices also experimentally an HPM source with 9.382 GHz, 25...
RNA-binding proteins (RNA-BPs) play critical roles in development and disease to regulate gene expression. However, genome-wide identification of their targets primary human cells has been challenging. Here, we applied a modified CLIP-seq strategy identify the FMRP translational regulator 1 (FMR1), brain-enriched RNA-BP, whose deficiency leads Fragile X Syndrome (FXS), most prevalent inherited intellectual disability. We identified FMR1 dorsal ventral forebrain neural progenitors excitatory...
Abstract Background Disruptions of SETBP1 (SET binding protein 1) on 18q12.3 by heterozygous gene deletion or loss-of-function variants cause disorder. Clinical features are frequently associated with moderate to severe intellectual disability, autistic traits and speech motor delays. Despite the association neurodevelopmental disorders, little is known about its role in brain development. Methods Using CRISPR/Cas9 genome editing technology, we generated a model human embryonic stem cells...
Fragile X messenger ribonucleoprotein 1 protein (FMRP) binds many mRNA targets in the brain. The contribution of these to fragile syndrome (FXS) and related autism spectrum disorder (ASD) remains unclear. Here, we show that FMRP deficiency leads elevated microtubule-associated 1B (MAP1B) developing human non-human primate cortical neurons. Targeted MAP1B gene activation healthy neurons or triplication ASD patient-derived inhibit morphological physiological maturation. Activation Map1b adult...
Human patient-derived induced pluripotent stem cells (hiPSCs) provide unique opportunities for disease modeling and drug development. However, adapting hiPSCs or their differentiated progenies to high throughput assays phenotyping screening has been challenging. Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability a major genetic autism. FXS caused by mutational trinucleotide expansion in FMR1 gene leading hypermethylation silencing. One potential...
Traumatic brain injury (TBI) is a leading cause of long-term disability in young adults and induces complex neuropathological processes. Cellular autonomous intercellular changes during the subacute phase contribute substantially to neuropathology TBI. However, underlying mechanisms remain elusive. In this study, we explored dysregulated cellular signaling TBI.Single-cell RNA-sequencing data (GSE160763) TBI were analyzed explore cell-cell communication Upregulated neurotrophic factor was...
Many insects possess acute directional hearing capabilities and are able to localize sound sources of interest with an astonishing degree precision. An analogy can be drawn between the auditory systems such electrically small antenna arrays that demonstrate enhanced sensitivity direction arrival electromagnetic wave, compared regular occupying same aperture. Inspired by this, we discuss design biologically inspired mimic mechanism insects. A method for designing is presented, tradeoffs...
Circular RNA (circRNA), a novel class of non-coding RNA, has closed-loop structure with important functions in skeletal muscle growth. The purpose this study was to investigate the role differentially expressed circRNAs (DEcircRNAs), as well DEcircRNA-miRNA-mRNA regulatory network, at different stages porcine development. Here, we present panoramic view circRNA expression from Large White and Mashen pigs 1, 90, 180 days age.We identified total 5819 circRNAs. DEcircRNA analysis showed 327...
Post-Traumatic Stress Disorder (PTSD) is a chronic mental disorder characterized by symptoms of panic and anxiety, depression, impaired cognitive functioning, difficulty in social interactions. While the effect traditional Chinese medicine artemisinin (AR) on PTSD unknown, its therapeutic benefits have been demonstrated studies models multiple neurological disorders. This study aimed to extend such findings investigating effects AR administration rat model induced regimen single prolonged...
Coordinated gene transcription in plastid and nucleus is essential for the photosynthetic apparatus assembly during chloroplast biogenesis. Despite identification of several factors regulating nuclear-encoded genes,no factor has been discovered. Here we report that BAI1 ("albino" Chinese), a nucleus-plastid dual-targeted C2H2-type zinc finger Arabidopsis, positively regulates orchestrates nuclear genes. The knockout leads to blockage formation, albino seedling, lethality. In plastid, newly...