A5020071619- Biochemical Analysis and Sensing Techniques
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipose Tissue and Metabolism
- Neuroendocrine regulation and behavior
- Olfactory and Sensory Function Studies
- Regulation of Appetite and Obesity
- Neuroscience and Neuropharmacology Research
- Diet and metabolism studies
- Tryptophan and brain disorders
- Diabetes Treatment and Management
- Vagus Nerve Stimulation Research
- Gut microbiota and health
- Heart Rate Variability and Autonomic Control
- Neuroscience of respiration and sleep
- Pancreatic function and diabetes
- Neonatal and fetal brain pathology
- Pain Management and Placebo Effect
- Preterm Birth and Chorioamnionitis
- Birth, Development, and Health
- Receptor Mechanisms and Signaling
- Nicotinic Acetylcholine Receptors Study
- Circadian rhythm and melatonin
- Reproductive System and Pregnancy
- Infant Health and Development
Universidad Autónoma Metropolitana
2015-2024
Leiden University
2015-2021
ETH Zurich
2009-2020
Bridge University
2019
University of Puerto Rico at Carolina
2019
Karolinska Institutet
2019
Essen University Hospital
2019
New South Wales Department of Health
2017
Universidad Metropolitana
2016
École Polytechnique Fédérale de Lausanne
2009-2015
In addition to metabolic and cardiovascular disorders, obesity is associated with adverse cognitive emotional outcomes. Its growing prevalence in adolescents particularly alarming since this a period of ongoing maturation for brain structures (including the hippocampus amygdala) hypothalamic-pituitary-adrenal (HPA) stress axis, which required processing. We recently demonstrated that adolescent, but not adult, high-fat diet (HF) exposure leads impaired hippocampal function enhanced amygdala...
The irreversible and progressive neurodegenerative Alzheimer’s disease (AD) is characterized by cognitive decline, extracellular β-amyloid peptide accumulation, tau neurofibrillary tangles in the cortex hippocampus. triple-transgenic (3xTg) mouse model of AD presents memory impairment several behavioral paradigms histopathological alterations from 6 to 16 months old. Additionally, it seems that dysbiotic gut microbiota present both models patients at symptomatic stage. study aimed assess...
We have previously demonstrated behaviorally conditioned immunosuppression using cyclosporin A as an unconditioned stimulus and saccharin a stimulus. In the current study, we examined central processing of this phenomenon generating excitotoxic lesions before after acquisition to discriminate between learning memory processes. Three different brain areas were analyzed: insular cortex (IC), amygdala (Am), ventromedial nucleus hypothalamus (VMH). The results demonstrate that IC performed...
Schizophrenia is associated with increased risk for multiple metabolic abnormalities, including altered glucose homeostasis, type-2 diabetes, obesity, and cardiovascular disease. Some of the alterations can already exist in psychosis-prone subjects prior to onset chronic schizophrenic disease pharmacotherapy, indicating that they may have a developmental origin. In present study, we tested hypothesis pertinent be primed by an environmental factor disorder, namely prenatal exposure immune...
To address the neural mediation of eating-inhibitory effect circulating glucagon-like peptide-1 (GLP-1), we investigated effects 1) intra-fourth ventricular infusion GLP-1 receptor antagonist exendin-9 or 2) area postrema lesion on intrameal hepatic portal vein (HPV) in adult male rats. evaluate physiological relevance observed examined 3) influence flavor acceptance a 2-bottle conditioned avoidance test, and 4) measured active HPV vena cava (VC) relation to meal VC after infusion. Intrameal...
Glucagon‐like peptide‐1 receptor ( GLP ‐1R) agonists such as exendin‐4 E x‐4) affect eating and metabolism are potential candidates for treating obesity type II diabetes. In the present study, we tested whether vagal afferents mediate eating‐inhibitory avoidance‐inducing effects of x‐4. Subdiaphragmatic deafferentation SDA ) blunted short‐term (< 1 h) but not long‐term effect i.p.‐infused x‐4 (0.1 μg/kg) in rats. A dose μg/kg reduced 0.5, 1, 2 4 h cumulative food intake s ham‐operated...
We recently reported that brief, remotely controlled intrameal hepatic‐portal vein infusions of glucagon‐like peptide‐1 (GLP‐1) reduced spontaneous meal size in rats. To investigate the neurobehavioural correlates this effect, we equipped male Sprague‐Dawley rats with catheters and assessed (i) effect on eating triggered GLP‐1 (1 nmol/kg, 5 min) or vehicle during first nocturnal after 3 h food deprivation (ii) identical performed at dark onset c‐Fos expression several brain areas involved...
Alzheimer's disease (AD) is a multifactorial pathology characterized by β-amyloid (Aβ) deposits, Tau hyperphosphorylation, neuroinflammatory response, and cognitive deficit. Changes in the bacterial gut microbiota (BGM) have been reported as possible etiological factor of AD. We assessed offspring (F1) 3xTg, effect BGM dysbiosisdysbiosis mothers (F0) at gestation F1 from lactation up to age 5 months on Aβ levels hippocampus, well spatial memory early symptomatic stage found that with...
Acyl CoA:diacylglycerol acyltransferase-1 (DGAT-1) catalyzes the final step in triacylglycerol (TAG) synthesis and is highly expressed small intestine. Because DGAT-1 knockout mice are resistant to diet-induced obesity, we investigated acute effects of intragastric (IG) infusion a molecule diacylglycerol inhibitor (DGAT-1i) on eating, circulating fat metabolites, indirect calorimetry, hepatic intestinal expression key catabolism enzymes male rats adapted an 8 h feeding-16 deprivation...
Acupuncture is the most popular component of traditional Chinese medicine in Western countries. However, mechanisms its effects remain unclear. The therapeutic effect acupuncture appears when a sensation DeQi achieved. We previously reported that repeated, but not single treatment affected leukocyte circulation and blood pressure healthy young humans. objective this study was to quantify by using visual analog scales (VASs) and, test whether induction an important factor for same cohort....
Pavlovian conditioning is one of the major neurobiological mechanisms placebo effects, potentially influencing course specific diseases and response to a pharmacological therapy, such as immunosuppression. In our study with behaviorally conditioned rats, relevant taste (0.2% saccharin) preceded application immunosuppressive drug cyclosporin A (CsA), calcineurin (CaN) inhibitor. Our results demonstrate that through pavlovian particular properties CsA can be transferred neutral taste, i.e.,...