A5036605478- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Olfactory and Sensory Function Studies
- Receptor Mechanisms and Signaling
- Photoreceptor and optogenetics research
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Peroxisome Proliferator-Activated Receptors
- Neuroendocrine regulation and behavior
- Neuroscience and Neural Engineering
- Molecular Communication and Nanonetworks
- Neural Networks and Applications
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Neurotransmitter Receptor Influence on Behavior
McGill University
2016-2024
Douglas Mental Health University Institute
2016-2024
NutriNeuro
2016-2020
Université de Bordeaux
2016-2019
Leibniz Association
2017
Slow gamma oscillations (30-60 Hz) correlate with retrieval of spatial memory. Altered slow have been observed in Alzheimer's disease. Here, we use the J20-APP AD mouse model that displays memory loss as well reduced amplitude and phase-amplitude coupling to theta phase. To restore hippocampus, used optogenetics activate medial septal parvalbumin neurons at different frequencies. We show optogenetic stimulation 40 Hz (but not 80 restores hippocampal amplitude, J20 model. Restoration during...
Abstract The precise temporal coordination of activity in the brain is thought to be fundamental for memory function. Inhibitory neurons medial septum provide a prominent source innervation hippocampus and play major role controlling hippocampal theta (~8 Hz) oscillations. While pharmacological inhibition septal known disrupt memory, exact inhibitory regulating representations not fully understood. Here, we dissociate rhythms spatiotemporal coding using an all-optical interrogation recording...
The hippocampal spatial code's relevance for downstream neuronal populations-particularly its major subcortical output the lateral septum (LS)-is still poorly understood. Here, using calcium imaging combined with unbiased analytical methods, we functionally characterized and compared tuning of LS GABAergic cells to those dorsal CA3 CA1 cells. We identified a significant number that are modulated by place, speed, acceleration, direction, as well conjunctions these properties, directly...
The hippocampus is a higher-order brain structure responsible for encoding new episodic memories and predicting future outcomes. In the absence of external stimuli, neurons in track elapsed time, distance traveled, other idiothetic variables. To this day, exact determinants representations during free navigation remain unclear. Here, we developed unsupervised approaches to extract population single-cell properties more than 30,000 CA1 pyramidal freely moving mice. We find that spatiotemporal...
The hippocampus is a higher-order brain structure responsible for encoding new episodic memories and predicting future outcomes. In absence of external stimuli, neurons in the express sequential activities which have been proposed to support path integration by tracking elapsed time, distance traveled, other idiothetic variables. On hand, with sufficient sensory inputs, hippocampal can fire respect allocentric cues. Previously, these codes described conditions where running speed clamped...
Abstract The hippocampal spatial code’s relevance for downstream neuronal populations – particularly its major subcortical output the lateral septum (LS) - is still poorly understood. Here, using calcium imaging combined with unbiased analytical methods, we functionally characterized and compared tuning of LS GABAergic cells to those dorsal CA3 CA1 cells. We identified a significant number that are modulated by place, speed, acceleration, direction, as well conjunctions these properties,...
Abstract The precise temporal coordination of activity in the brain is thought to be fundamental for memory encoding and retrieval. Pacemaker GABAergic neurons medial septum (MS) provide largest source innervation hippocampus play a major role controlling hippocampal theta (~8 Hz) oscillations. While pharmacological inhibition MS known disrupt memory, exact inhibitory frequency rhythms representations not fully understood. Here, we dissociate spatiotemporal coding using an all-optical...
Reward-processing impairment is a common symptomatic dimension of several psychiatric disorders. However, whether the underlying pathological mechanisms are unknown. Herein, we asked if decrease in n-3 Polyunsaturated Fatty Acids (PUFAs) lipid species, consistently described these pathologies, could underlie reward-processing deficits. We show that reduced PUFA biostatus mice leads to selective motivational Electrophysiological recordings revealed increased collateral inhibition dopamine D2...