A5022075524- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Eating Disorders and Behaviors
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Tryptophan and brain disorders
- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Metabolism and Genetic Disorders
- Peroxisome Proliferator-Activated Receptors
- Fatty Acid Research and Health
- Parkinson's Disease Mechanisms and Treatments
- Alcoholism and Thiamine Deficiency
- Neurological disorders and treatments
- Pulmonary Hypertension Research and Treatments
- Muscle metabolism and nutrition
- Neurological and metabolic disorders
- Advanced Proteomics Techniques and Applications
- Vitamin K Research Studies
- Metabolomics and Mass Spectrometry Studies
- Obsessive-Compulsive Spectrum Disorders
- Genetics and Neurodevelopmental Disorders
- Nerve injury and regeneration
- Schizophrenia research and treatment
- Diabetes Treatment and Management
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2021-2024
Université de Bordeaux
2018-2024
NutriNeuro
2015-2024
Institut Polytechnique de Bordeaux
2019-2024
University Medical Center Utrecht
2021-2024
Utrecht University
2023-2024
Centre Hospitalier Chrétien
2024
Heidelberg University
2021
University Hospital Heidelberg
2021
Epidemiological studies indicate that insulin resistance (IR), a hallmark of type 2 diabetes, is associated with an increased risk major depression. Here, we demonstrated male mice fed high-fat diet (HFD) exhibited peripheral metabolic impairments reminiscent IR accompanied by elevated circulating levels branched-chain amino acids (BCAAs), whereas both parameters were normalized chronic treatment metformin (Met). Given the role BCAAs in regulation tryptophan influx into brain, then explored...
Abstract Accumulating evidence points to dysregulations of the Nucleus Accumbens (NAc) in eating disorders (ED), however its precise contribution ED symptomatic dimensions remains unclear. Using chemogenetic manipulations male mice, we found that activity dopamine D1 receptor-expressing neurons NAc core subregion facilitated effort for a food reward as well voluntary exercise, but decreased intake, while D2-expressing have opposite effects. These effects are congruent with D2-neurons being...
The recent developments in mass spectrometry have revealed the importance of lipids as biomarkers context different diseases and indicators cell's homeostasis. However, further advances are required to unveil complex relationships between lipid classes species with proteins. Here, we present a new methodology that combines microarrays obtain fingerprint samples nature standardized fast way, minimal sample consumption. As proof concept, use 20 rat tissues create library for tissue...
Semaglutide, a glucagon-like peptide-1 receptor agonist, is an effective drug reducing body weight and decreasing motivation for palatable food. The mechanisms underlying its effects on food reward remain unclear. We aimed to determine the impact of semaglutide collection dopamine-neuron activity in ventral tegmental area (VTA) upon exposure cue-induced sucrose delivery task. Pitx3-cre mice were injected with cre-dependent GCaMP6s virus into VTA, measure dopaminergic neurons VTA using vivo...
Objective A growing body of evidence suggests that obesity could result from alterations in reward processing. In rodent models, chronic exposure to an obesogenic diet leads blunted dopamine signaling and related incentive responding. This study aimed determine which reward‐related behavioral dimensions are actually impacted by exposure. Methods Mice were chronically exposed diet. Incentive hedonic processes tested through operant conditioning licking microstructures, respectively. parallel,...
ABSTRACT Anorexia nervosa (AN) has the highest mortality among psychiatric diseases. Hyperactivity is a persistent symptom, which difficult to control for patients and major barrier recovery as it interferes with weight gain. Alteration of mesolimbic dopamine transmission been hypothesized critical factor development maintenance disease hyperactivity. At what level changes in occur anorexic states whether local neurocircuit plasticity causally involved remains unclear. Especially role GABA...
<title>Abstract</title> Anorexia nervosa (AN) has the highest mortality among psychiatric diseases. Hyperactivity is a persistent symptom and alteration of mesolimbic dopamine transmission been linked to development maintenance disease hyperactivity. However, whether local neurocircuit plasticity causally involved remains unclear. Especially role GABA control over neurons, powerful regulator system, in an AN context unresolved. We hypothesize that combining caloric restriction with exercise...
Type-2 Diabetes mellitus (T2DM) is mainly characterized by insulin-resistance and often accompanied comorbidities such as major depressive disorders (MDD). Indeed, patients with T2DM are twice more likely to suffer from MDD clinical studies have shown that insulin resistance positively correlated the severity of symptoms. In preclinical studies, we others showed mice fed a High Fat Diet (HFD) for 16 weeks display both hallmarks including increased basal blood glucose level impaired tolerance...
Reward-processing impairment is a common symptomatic dimension of several psychiatric disorders. However, whether the underlying pathological mechanisms are unknown. Herein, we asked if decrease in n-3 Polyunsaturated Fatty Acids (PUFAs) lipid species, consistently described these pathologies, could underlie reward-processing deficits. We show that reduced PUFA biostatus mice leads to selective motivational Electrophysiological recordings revealed increased collateral inhibition dopamine D2...