A5069159067- Fatty Acid Research and Health
- Eicosanoids and Hypertension Pharmacology
- Cholesterol and Lipid Metabolism
- Lipid metabolism and biosynthesis
- Antioxidant Activity and Oxidative Stress
- Peroxisome Proliferator-Activated Receptors
- Biochemical Analysis and Sensing Techniques
- Analytical Chemistry and Chromatography
- Metabolomics and Mass Spectrometry Studies
- Edible Oils Quality and Analysis
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Glycosylation and Glycoproteins Research
- Retinoids in leukemia and cellular processes
- Free Radicals and Antioxidants
- Advanced Chemical Sensor Technologies
- Nuts composition and effects
- Olfactory and Sensory Function Studies
- Plant biochemistry and biosynthesis
- Advanced Glycation End Products research
- Steroid Chemistry and Biochemistry
- Cancer, Lipids, and Metabolism
- Adipose Tissue and Metabolism
- Biochemical effects in animals
- Inflammatory mediators and NSAID effects
Université de Bourgogne
2014-2024
Centre National de la Recherche Scientifique
2011-2024
Centre des Sciences du Goût et de l'Alimentation
2015-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2021-2024
Université Bourgogne Franche-Comté
2016-2024
L'Institut Agro
2024
Institut Agro Dijon
2010-2022
Chemo (France)
2021
Institut National de la Recherche Agronomique
1996-2013
Centre de recherche Translationnelle en Médecine moléculaire
1996-2009
Background The assessment of blood lipids is very frequent in clinical research as it assumed to reflect the lipid composition peripheral tissues. Even well accepted such relationships have never been clearly established. This particularly true ophthalmology where use has become common following recent data linking intake ocular health and disease. In present study, we wanted determine humans whether a lipidomic approach based on red cells could reveal associations between circulating tissue...
Understanding the molecular mechanisms underlying changes observed during aging is a prerequisite to design strategies prevent age-related diseases. Aging associated with metabolic changes, including alteration in brain lipid metabolism. These alterations may contribute development of pathophysiological conditions. Modifications gut microbiota composition are also aging. As communication axis exist between and knowing that influences host metabolism, we speculated on whether age-associated...
There is a continued unmet need for treatments that can slow Parkinson's disease progression due to the lack of understanding behind molecular mechanisms underlying neurodegeneration. Since its discovery, ferroptosis has been implicated in several diseases and represents therapeutic target disease. Here, we use two highly relevant human dopaminergic neuronal models show endogenous levels α-synuclein determine sensitivity neurons ferroptosis. We reducing expression leads evasion, while...
Abstract The influence of individual conjugated linoleic acid (CLA) isomers on the Δ6 desaturation and α‐linolenic acids Δ9 stearic was investigated in vitro , using rat liver microsomes. 18∶2n−6 decreased from 23 to 38% when ratio 9 cis ,11 trans ‐18∶2 increased 0.5 2. compound 10 ,12 exhibited a similar effect only at highest concentration. slightly affected by presence CLA isomers. sole isomer induce an inhibitory ‐18∶2.
Long-chain polyunsaturated fatty acids (LC-PUFA) of the n-3 series, particularly eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid, have specific activities especially in functionality central nervous system. Due to occurrence numerous methylene-interrupted ethylenic double bonds, these are very sensitive air (oxygen) temperature. Non-volatile degradation products, which include polymers, cyclic acid monomers (CFAM) geometrical isomers EPA DHA, were evaluated fish oil samples obtained by...
The anti-atherogenic effects of omega 3 fatty acids, namely eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) are well recognized but the impact dietary intake on bioactive lipid mediator profiles remains unclear. Such a profiling effort may offer novel targets for future studies into mechanism action acids. present study aimed to determine DHA supplementation polyunsaturated (PUFA) oxygenated metabolites investigate their contribution atherosclerosis prevention. A special emphasis was...
A large set of xenobiotic-metabolizing enzymes (XMEs), such as the cytochrome P450 monooxygenases (CYPs), esterases and transferases, are highly expressed in mammalian olfactory mucosa (OM). These known to catalyze biotransformation exogenous compounds facilitate elimination. However, functions these epithelium not clearly understood. In addition protecting against inhaled toxic compounds, could also metabolize odorant molecules, thus modify their stimulating properties or inactivate them....
Abstract Male weanling Wistar rats ( n =15), weighing 200–220 g, were allocated for 6 wk to diets containing 1% (by weight) of conjugated linoleic acid (CLA), either as the 9 c ,11 t ‐isomer, 10 ,12 or a mixture 45% each these isomers. The five control group received oleic instead. Selected enzyme activities determined in different tissues after cellular subfractionation. None CLA‐diet induced hepatic peroxisome‐proliferation response, evidenced by lack change activity some characteristic...
Abstract Conjugated linoleic acid (CLA) is a collective term that describes different isomers of with conjugated double bonds. Although the main dietary isomer 9 cis ,11 trans ‐18∶2, which present in dairy products and ruminant fat, biological effects CLA generally have been studied using mixtures ‐ 10 ,12 ‐18∶2 were at similar levels. In work, we impact each (9 ‐18∶2) given separately diet rats for 6 wk. The decreased triacylglycerol content liver (−32%) increased 18∶0 expense 18∶1n−9,...
Background Long chain polyunsaturated fatty acids (LCPUFAs) including docosahexaenoic acid and arachidonic are suspected to play a key role in the pathogenesis of diabetes. LCPUFAs known be preferentially concentrated specific phospholipids termed as plasmalogens. This study was aimed highlight potential changes metabolism phospholipids, particularly plasmalogens, at various stages diabetic retinopathy humans. Methodology Principal Findings We performed lipidomic analyses on red blood cell...
The oxidised derivatives of phytosterols (oxyphytosterols) were identified in plasma samples from thirteen healthy human volunteers, using MS. All the contained noticeable quantities (24R)-5beta,6beta-epoxy-24-ethylcholestan-3beta-ol (beta-epoxysitostanol) and (24R)-ethylcholestan-3beta,5alpha,6beta-triol (sitostanetriol) also trace levels (24R)-5alpha,6alpha-epoxy-24-ethylcholestan-3beta-ol (alpha-epoxysitostanol), (24R)-methylcholestan-3beta,5alpha,6beta-triol (campestanetriol)...
ABSTRACT Fat perception is assumed to result, at least in part, from in‐mouth non‐esterified fatty acids (NEFAs) detection. The aim of this study was better understand how human oral physiology may govern the sensory sensitivity NEFAs. For purpose, detection thresholds for oleic acid were determined 17 subjects with highly varying salivary and characteristics, related their characteristics conventional multidimensional data analysis. These tested on a dairy oil‐in‐water emulsion that...
Abstract The conjugated linoleic acid methyl cis ‐9, trans ‐11‐octadecadienoate has been prepared on a large scale from ricinoleate. Methyl ricinoleate was purified castor esters by partition method. It converted to the mesylate, which reacted with base (1,8‐diazabicyclo[5,4,0]‐undec‐7‐ene) give product that contained 66% of desired ester. Two urea crystallizations produced containing 83% ‐11‐octadecadienoate, identity confirmed gas chromatography linked mass spectrometry and Fourier...
Omega-3 (n-3) polyunsaturated fatty acids (PUFAs), particularly docosahexaenoic acid (DHA), are required for the structure and function of retina. Several observational studies indicate that consumption a diet with relatively high levels n-3 PUFAs, such as those provided by fish oils, has protective effect against development age-related macular degeneration. Given accumulating evidence showing role gut microbiota in regulating retinal physiology host lipid metabolism, we evaluated potential...